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ROCK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19251 | ZINC00881524 | 557782-81-7 | ZINC00881524 is an inhibitor of ROCK. |
| CSN13431 | Y-33075 2HCl | 173897-44-4 | Y-39983 HCl is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM. |
| CSN18082 | Y-33075 | 199433-58-4 | Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 0.14 μM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase. |
| CSN12226 | Y-27632 | 146986-50-7 | Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. |
| CSN13895 | Y-27632 2HCl | 129830-38-2 | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits > 200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| CSN16967 | SLx-2119 | 911417-87-3 | SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM, which is over 200 fold selecivity over ROCK1 (IC50 =24 μM). |
| CSN18502 | ROCK Inhibitor | 867017-68-3 | ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively. |
| CSN15904 | RKI-1447 | 1342278-01-6 | RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, and has anti-invasive and antitumor activities. |
| CSN16953 | K-115 | 223645-67-8 | K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension. |
| CSN17105 | Hydroxyfasudil | 105628-72-6 | Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| CSN15927 | Hydroxyfasudil HCl | 155558-32-0 | Hydroxyfasudil HCl, metabolite of fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| CSN16493 | H-1152 | 451462-58-1 | H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| CSN16231 | GSK429286A | 864082-47-3 | GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively. |
| CSN18470 | GSK269962 | 850664-21-0 | GSK269962A is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively), and displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. |
| CSN19208 | GSK269962 HCl | 2095432-71-4 | GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
| CSN25217 | GSK-25 | 874119-56-9 | GSK-25 is a ROCK1 inhibitor with IC50 value of 6nM. It showed oral bioavailability (49% in rat and 19% in monkey), good half-life (1.8 h in rat and 2.2 h in monkey) and gave a robust 25 mmHg reduction mean arterial pressure in spontaneously hypertensive rats at a single dose of 30 mg/kg. |
| CSN10984 | Fasudil HCl | 105628-07-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN10983 | Fasudil | 103745-39-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
