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ROCK

ROCK

货号 产品名 CAS号 信息
CSN19251 ZINC00881524 557782-81-7 ZINC00881524 is an inhibitor of ROCK.
CSN13431 Y-33075 dihydrochloride 173897-44-4 Y-39983 HCl is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.
CSN18082 Y-33075 199433-58-4 Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 0.14 μM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase.
CSN12226 Y-27632 146986-50-7 Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively.
CSN13895 Y-27632 dihydrochloride   129830-38-2 Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits > 200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
CSN26523 Verosudil 1414854-42-4 Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
CSN12292 Thiazovivin   1226056-71-8 Thiazovivin is a ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation.
CSN17184 SR-3677 1072959-67-1 SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays, and its IC50 for ROCK-I is 56 ± 12 nM.
CSN16967 Belumosudil 911417-87-3 SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM, which is over 200 fold selecivity over ROCK1 (IC50 =24 μM).
CSN18583 SAR407899 923359-38-0 SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.
CSN16099 SAR407899 hydrochloride 923262-96-8 SAR407899 HCl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.
CSN22498 ROCK2-IN-2 1995065-79-6 ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.
CSN18502 BAY-549 867017-68-3 ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.
CSN15904 RKI-1447 1342278-01-6 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, and has anti-invasive and antitumor activities.
CSN19802 RKI-1313 1342276-76-9 RKI-1313 is a negative control for RKI-1447 (GLXC-05200) which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
CSN17627 Netarsudil (AR-13324) 2HCl 1253952-02-1 Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes.
CSN29547 (S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate 1254032-66-0 Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
CSN17539 LX7101 1192189-69-7 LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively and also inhibits PKA with an IC50 less than 1 nM.
CSN16953 Ripasudil free base 223645-67-8 K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension.
CSN16952 Ripasudil 887375-67-9 K-115 HCl is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.
CSN17105 Hydroxyfasudil 105628-72-6 Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
CSN15927 Hydroxyfasudil hydrochloride 155558-32-0 Hydroxyfasudil HCl, metabolite of fasudil, is a potent Rho-kinase inhibitor and vasodilator.
CSN16493 H-1152 451462-58-1 H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
CSN16045 H-1152 dihydrochloride 871543-07-6 H-1152 2HCl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
CSN16231 GSK429286A 864082-47-3 GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively.
CSN18470 GSK269962A 850664-21-0 GSK269962A is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively), and displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.
CSN19208 GSK269962A hydrochloride 2095432-71-4 GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
CSN25217 GSK-25   874119-56-9 GSK-25 is a ROCK1 inhibitor with IC50 value of 6nM. It showed oral bioavailability (49% in rat and 19% in monkey), good half-life (1.8 h in rat and 2.2 h in monkey) and gave a robust 25 mmHg reduction mean arterial pressure in spontaneously hypertensive rats at a single dose of 30 mg/kg.
CSN22832 Glycyl H-1152 hydrochloride 913844-45-8 Glycyl-H 1152 2HCl is a selective Rho-kinase (ROCK) inhibitor with IC50 of 0.0118 μM for ROCKII.
CSN10984 Fasudil Hydrochloride 105628-07-7 Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
CSN10983 Fasudil 103745-39-7 Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
CSN26558 CRT0066854 hydrochloride 2250019-91-9 CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].
CSN17653 Chroman 1 1273579-40-0 Chroman 1 is a highly potent and selective ROCK II inhibitor.
CSN42722 Belumosudil mesylate 2109704-99-4 Belumosudil is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM, which is over 200 fold selecivity over ROCK1 (IC50 =24 μM).
CSN13758 AT13148 1056901-62-2 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
CSN22686 AS1892802 928320-12-1 AS 1892802 is a potent, ATP-competitive ROCK inhibitor with IC50s of 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively.
CSN17830 AR-13324 Mesylate 2166548-12-3 AR-13324 mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter which inhibits kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells.
CSN18948 AR-13324 Mesylate Analog N/A AR-13324 mesylate analog is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter and reduces intraocular pressure (IOP) in normotensive monkey eyes.
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