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ROCK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19251 | ZINC00881524 | 557782-81-7 | ZINC00881524 is an inhibitor of ROCK. |
| CSN13431 | Y-33075 2HCl | 173897-44-4 | Y-39983 HCl is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM. |
| CSN18082 | Y-33075 | 199433-58-4 | Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 0.14 μM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase. |
| CSN12226 | Y-27632 | 146986-50-7 | Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. |
| CSN13895 | Y-27632 2HCl | 129830-38-2 | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits > 200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| CSN26523 | Verosudil | 1414854-42-4 | Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG. |
| CSN22498 | ROCK2-IN-2 | 1995065-79-6 | ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. |
| CSN16953 | K-115 | 223645-67-8 | K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension. |
| CSN17105 | Hydroxyfasudil | 105628-72-6 | Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| CSN15927 | Hydroxyfasudil HCl | 155558-32-0 | Hydroxyfasudil HCl, metabolite of fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| CSN16231 | GSK429286A | 864082-47-3 | GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively. |
| CSN10984 | Fasudil HCl | 105628-07-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN10983 | Fasudil | 103745-39-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN17653 | Chroman 1 | 1273579-40-0 | Chroman 1 is a highly potent and selective ROCK II inhibitor. |
