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ROR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN23199 | XY018 | 1873358-87-2 | XY 018 is a RORγ antagonist that suppresses androgen receptor expression in prostate cancer cell lines and inhibits growth of tumors in androgen receptor-positive xenograft models. |
| CSN22520 | TMP778 | 1422171-08-1 | TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. |
| CSN18188 | SR3335 | 293753-05-6 | SR3335 can selectively bind to RORα and competitively inhibit the binding of 25-hydroxycholesterol to the ligand binding domain with Ki of 220 nM. |
| CSN23128 | SR2211 | 1359164-11-6 | SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. |
| CSN17703 | SR1001 | 1335106-03-0 | SR1001 is a selective RORα and RORγ inverse agonist and inhibits TH17 cell differentiation and function. |
| CSN17619 | SR1078 | 1246525-60-9 | SR-1078 is an agonist of RORα and RORγ and can increase transcriptional activity of RORα with 2 μM. |
| CSN23654 | SR0987 | 303126-97-8 | SR 0987 is an agonist of T cell-specific RORγ (RORγt) with EC50 of 800 nM. It can induce IL-17 expression and decrease PD-1 expression in T cells. |
| CSN17833 | GSK805 | 1426802-50-7 | RORγt-IN-1 is a potent, orally bioavailable RORγt inhibitor with pIC50 of 8.4 and > 8.2 for RORγ FRET assay and Th17 assay. |
| CSN26755 | RORγt Inverse agonist 10 | 2413986-35-1 | RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R[1] |
| CSN21998 | Vimirogant | 1802706-04-2 | RORγ-IN-1 is a RORγ inhibitor extracted from patent US 9481674 B1, with a Ki of <100 nM. |
| CSN27568 | PF-06747711 | 1892576-58-7 | PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity. |
| CSN17892 | GSK2981278 | 1474110-21-8 | GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator. |
| CSN22420 | GNE-6468 | 1677668-27-7 | GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell. |
| CSN22418 | GNE-0946 | 1677667-24-1 | GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell. |
| CSN26753 | RORγt Inverse agonist 3 | 2364429-77-4 | for hRORγ and RORγt (human IL-17 cells), respectively[1]. |
| CSN22621 | (±)-ML 209 | 1334526-14-5 | (±)-ML 209 is a RORγt inverse agonist with IC50 of 460 nM. |
| CSN51378 | RORγt inhibitor 1 | 1561770-72-6 |
