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Ser/Thr Protease

Ser/Thr Protease

货号 产品名 CAS号 信息
CSN18120 UKI-1 220355-63-5 UKI-1 is a synthetic inhibitor of the urokinase-type plasminogen activator system.
CSN21157 UK-371804 256477-09-5 UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
CSN23329 UK-371804 HCl 256476-36-5 UK-371804 HCl is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
CSN33151 TPCK 402-71-1 TPCK is a non-specific irreversible inhibitor of serine/cysteine proteases. It acts by inhibiting ScRce1 in the presence of a Ras reporter, but not in the presence of the a-factor peptide.
CSN26335 TLCK HCl 4272-74-6 TLCK hydrochloride inhibits serine proteinases with trypsin-like activity.
CSN26457 SRI31215 2TFA 1832686-44-8 SRI31215 2TFA is a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2. SRI31215 2TFA blocks signaling between cancer cells and fibroblasts and inhibits the tumor-promoting activity of cancer-associated fibroblasts.
CSN26760 Patamostat 114568-26-2 Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. E-3123 may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].
CSN23618 NSC95682 20035-41-0 NSC95682 is a derivative of bromobenzaldehyde which can inhibit inositol-requiring enzyme 1 α (IRE-1α) with IC50 of 0.08 μM.
CSN11508 Nafamostat Mesylate 82956-11-4 Nafamostat mesylate is a synthetic inhibitor of serine protease with anticoagulant activity.
CSN18442 Nafamostat 81525-10-2 Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
CSN18437 Nafamostat HCl 80251-32-7 Nafamostat HCl is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
CSN26395 K-252c 85753-43-1 K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase, with IC50 values of 8, 8 and 10 μM respectively[1][2][3].
CSN33248 2-(4-Bromophenyl)-2,3-dihydro-1H-perimidine 64369-13-7 Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM.
CSN11071 Gabexate Mesylate 56974-61-9 Gabexate mesylate could inhibit trypsin, plasmin, plasma kallikrein and thrombin with IC50s of 9.4 μM, 30 μM, 41 μM and 110 μM. It has certain anticoagulant effect.
CSN27644 FOY 251 71079-09-9 FOY-251 is a metabolite of Camostat that acts as a pollen protease inhibitor for prevention and control of allergies.
CSN22162 FK-448 Free base 85858-76-0 FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
CSN25456 Benzamidine HCl 1670-14-0 Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively.
CSN10326 Aprotinin 9087-70-1 Aprotinin is an inhibitor of serine protease which can inhibit trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM.
CSN23538 7H-Purin-2-amine 452-06-2 7H-Purin-2-amine, isomer of adenine, is an inhibitor of protein kinase R (PKR) with antimetabolite effect.
CSN24042 3,4-Dichloroisocoumarin 51050-59-0 3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components in vitro. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin.
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