|PROTAC SGK3 degrader-1
|SGK3-PROTAC1 is a PROTAC selectively targeting on SGK3 with DC50 value of 0.3μM within 2h, accompanied by a loss of phosphorylation of NDRG1, an SGK3 substrate. It comprises the 308-R SGK inhibitor with the VH032 VHL binding ligand.
|SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
|GSK650394 inhibits the activities of SGK1 and SGK2 with IC50 of 62 nM and 103 nM, respectively.
|EMD638683 S-form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
|EMD638683 R-form is the R-form of EMD638683, which is a highly selective SGK1 inhibitor with IC50 of 3 μM.
|EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 μM.