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Sirtuin

Sirtuin

货号 产品名 CAS号 信息
CSN25238 UBCS039   358721-70-7 UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes.
CSN32918 Omzotirome 1092551-88-6 TRC-150094 is a NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) activator.
CSN20494 Thiomyristoyl 1429749-41-6 Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM, 98 μM.
CSN15828 SRT 1720 Hydrochloride 2060259-60-9 The maximum activation ratio of SRT1720 versus the closest sirtuin homologues, SIRT2 (EC1.5 = 37 μM) and SIRT3 (EC1.5 > 300 μM) is up to 781%.
CSN15867 Tenovin-6 1011557-82-6 Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.
CSN17390 Tenovin-6 Hydrochloride 1011301-29-3 Tenovin 6 HCl is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.
CSN26139 2-(3-(2-Morpholinoethoxy)phenyl)-N-(thiazol-2-yl)-1H-benzo[d]imidazole-7-carboxamide 1203480-93-6 SRTCX1003 is a Sirtuin 1 activator. It enhanced deacetylation of cellular p65 protein, which resulted in the suppression of TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
CSN26766 SRT3657 1383551-17-4 SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].
CSN18940 Sirtuin modulator 1 2070015-26-6 SRT3025 HCl is an orally available sirtuin modulator.
CSN19241 SRT 2183 1001908-89-9 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1.
CSN17459 SRT 2104 1093403-33-8 SRT2104 is an activator of SIRT1 which is involved in the regulation of energy homeostasis.
CSN12823 SRT 1720 925434-55-5 SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM).
CSN24314 SRT1720 HCl 1001645-58-4 SRT1720 2HCl is a selective SIRT1 activator.
CSN25631 SRT 1460 925432-73-1 SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay.
CSN12889 Splitomicin 5690-03-9 Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.
CSN20027 Sirtuin Inhibitor C18 1392810-44-4 Sirtuin inhibitor C18 is a histone deacetylase class III inhibitor of sirtuin 1 and 2 exerting antiproliferative activity against cancer cell lines.
CSN12523 Sirtinol 410536-97-9 Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
CSN28412 SIRT5 inhibitor 1 2166487-21-2 SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
CSN26762 SIRT1-IN-1 352554-02-0 SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2].
CSN19216 SirReal2 709002-46-0 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
CSN18937 Salermide 1105698-15-4 Salermide, a reverse amide, can act as an inhibitor of sirt, especially of sirt2, with the property of inducing apoptosis of tumor cells.
CSN22311 PROTAC Sirt2 Degrader-1 2098487-75-1 PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide.
CSN25457 OSS_128167 887686-02-4 OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.
CSN26763 Nicotinamide riboside malate 2415659-01-5 Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
CSN29498 Nicotinamide riboside 1341-23-7 Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.
CSN16796 Nicotinamide 98-92-0 Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP.
CSN16506 Isoliquiritigenin 961-29-5 Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound.
CSN15959 Inauhzin 309271-94-1 Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress (IC50=3 μM, in A549 cell).
CSN18677 Fisetin 528-48-3 Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities.
CSN15833 (S)-Selisistat 848193-68-0 EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM, showing no inhibition on SIRT3 and SIRT3.
CSN15817 (R)-Selisistat 848193-69-1 EX-527 R-enantiomer is the R-enantiomer of EX-527. EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM. EX-527 has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM).
CSN10146 Selisistat 49843-98-3 EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits > 200-fold selectivity against SIRT2 and SIRT3.
CSN23882 MDL-800 2275619-53-7 DL-800 is an allosteric and selective SIRT6 activator with EC50 of 10.3μM.
CSN21950 CAY10602 374922-43-7 CAY10602 is a SIRT1 activator.
CSN26404 Cambinol 14513-15-6 Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.
CSN16491 AK-7 420831-40-9 AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models.
CSN21121 AK-1 330461-64-8 AK-1 is a cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency.
CSN13831 AGK2 304896-28-4 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
CSN20654 3-TYP 120241-79-4 3-TYP is a selective inhibitor of SIRT3.
CSN28859 1-{4-[2-(5-methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one 1031195-19-3
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