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Sirtuin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25238 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| CSN26766 | SRT3657 | 1383551-17-4 | SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1]. |
| CSN18940 | SRT3025 HCl | 2070015-26-6 | SRT3025 HCl is an orally available sirtuin modulator. |
| CSN19241 | SRT2183 | 1001908-89-9 | SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1. |
| CSN24314 | SRT1720 2HCl | 1001645-58-4 | SRT1720 2HCl is a selective SIRT1 activator. |
| CSN12889 | Splitomicin | 5690-03-9 | Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay. |
| CSN12523 | Sirtinol | 410536-97-9 | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. |
| CSN28412 | SIRT5 inhibitor 1 | 2166487-21-2 | SIRT5 inhibitor 1 is "drug-like" and potent SIRT5 inhibitor with IC50 value of 0.11μM. |
| CSN19216 | SirReal2 | 709002-46-0 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
| CSN25457 | OSS_128167 | 887686-02-4 | OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects. |
| CSN26763 | Nicotinamide riboside malate | 2415659-01-5 | Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2]. |
| CSN29498 | Nicotinamide riboside | 1341-23-7 | Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. |
| CSN16796 | Nicotinamide | 98-92-0 | Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP. |
| CSN15959 | Inauhzin | 309271-94-1 | Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress (IC50=3 μM, in A549 cell). |
| CSN18677 | Fisetin | 528-48-3 | Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities. |
| CSN10146 | EX-527 | 49843-98-3 | EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits > 200-fold selectivity against SIRT2 and SIRT3. |
| CSN21950 | CAY10602 | 374922-43-7 | CAY10602 is a SIRT1 activator. |
| CSN26404 | CAmbinol | 14513-15-6 | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. |
| CSN16491 | AK-7 | 420831-40-9 | AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models. |
| CSN13831 | AGK2 | 304896-28-4 | AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
| CSN20654 | 3-TYP | 120241-79-4 | 3-TYP is a selective inhibitor of SIRT3. |
