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Inhibitors & Agonists

E3 Ligand Plus Linker

E3 Ligand Plus Linker (Pomalidomide)E3 Ligand Plus Linker (VH032)E3 Ligand Plus Linker (Thalidomide)E3 Ligand Plus Linker (Lenalidomide)E3 Ligand Plus Linker (other)

PROTACs

Bromodomain BET/PROTACVHL/PROTACFKBP/PROTACTRIM/PROTACCDK/PROTACALK/PROTACERR/PROTACPTK2/PROTACRaf/PROTACSirtuin/PROTACCRBN/PROTACMultikinase/PROTACp38/PROTACMDM2/PROTACK-Ras (G12C)/PROTACERα/PROTACCdc20/PROTACBcl-2/PROTACMcl-1/PROTACFAK/PROTACSGK3/PROTACBTK/PROTACRIP Kinase/PROTACFLT3-ITD/PROTACRAR/PROTACAPC/PROTACIAP/PROTACCRABP/PROTACEGFR/PROTACER/PROTACPCAF/PROTACPD-1 PD-L1/PROTACSHP-2/PROTACSTAT/PROTACTBK/PROTACBcl-xL/PROTACHalo/PROTAC

Functionalized E3 Ligand

Functionalized E3 Ligand (Thalidomide)Functionalized E3 Ligand (VH032)Functionalized E3 Ligand (Pomalidomide)Functionalized E3 Ligand (for VHL)Functionalized E3 Ligand (other)Functionalized E3 Ligand (Bestatin)

Linker

PROTAC Linker

Functionalized Warhead Ligand

Bromodomain BET/Warhead LigandBcr-Abl/Warhead LigandFKBP/Warhead LigandmTOR/Warhead LigandSirtuin/Warhead LigandCDK/Warhead Ligand

Anti-infection

AntibacterialAntifungalAntiparasiticAntiviralCCRCMVDengue VirusFilovirusHBVHCVHHVHIVHIV IntegraseHIV ProteaseHRVHSVInfluenza VirusLpxCNeuraminidaseNNRTINRTINS2B-NS3 ProteaseOrthopoxvirusPrionReverse TranscriptaseRSVSARS-CoVSQLEEBVVZVβ-lactamaseFCoV3CLproM2 proton channelAntiprotozoalViral MTasePLPGraRPeroxiredoxinBVDVSAMHD1Pks13

Apoptosis

Apoptosis InducerBcl-2Caspasec-Mycc-RETDAPKIAPMDM2p53PD-1/PD-L1PERKPKDSurvivinThymidylate SynthaseTNF-alphaG0/G1 switch protein 2MDM2/PROTACMcl-1 (stapled peptide)Bim (stapled peptide)Bcl-2 (stapled peptide)p53/MDM2 (stapled peptide)NecroptosisC/EBPBcl-2/PROTACMcl-1/PROTACIAP/PROTACPD-1 PD-L1/PROTACLTBR

Autophagy

AutophagyCXCRLRRK2LysosomeULKSPHKPPTmitoNEETTFEBLC3

Cell Cycle

APCAurora KinaseBUBCasein KinaseCDKChkc-MycCRISPR/Cas9CRM1DHFRDNA/RNA SynthesisDYRKeIFG-quadruplexHaspin KinaseHSFHSPIRE1KinesinLIMKMad2Microtubule/TubulinMps1Nucleoside Antimetabolite/Analogp21PAKPD-1/PD-L1PERKPLKPPARPTENRAD51RhoROCKWee1FOXM1MKLPCdc25TACCDOCKClathrinMARPLats kinaseHGFMRE11Cdc20/PROTACRNA polymerase 1DNA polymerase θPBRMAPC/PROTACPD-1 PD-L1/PROTACRNA polymerase 2PKMYT1

Cytoskeleton

AktArp2/3 ComplexDynaminFAKGap Junction ProteinHSPIntegrinKinesinMicrotubule/TubulinMps1MyosinPAKPKCSelectinWntβ-cateninActinSpastinGap JunctionMLCKTACCFAK/PROTACFilamin-ACYTH

DNA Damage

ATM/ATRDNA Alkylator/CrosslinkerDNA/RNA SynthesisDNA-PKHDACMTH1PARPSirtuinTelomeraseTopoisomeraseHDRAP endonucleaseOGGATAD5MRE11WRNBRCARMI1RAD52ADARREV1

Endocrinology/Hormones

5 Alpha ReductaseACEAndrogen ReceptorAromataseERRGlucocorticoid ReceptorGPCR
Growth HormoneOpioid ReceptorProgesterone ReceptorReninTPOTRHRThyroid Hormone ReceptorTTRPTGRER/PROTACGHSR

Epigenetics

AMPKAurora KinaseCECR2DNA MethyltransferaseEpigenetic Reader DomainHDACHIFHistone AcetyltransferaseHistone DemethylaseHistone MethyltransferaseJAKMicroRNAPADPARPPimPKCSirtuinTETMBD-containing proteinEZH2 (stapled peptide)HESFTOPBRMPCAF/PROTACMETTL3

GPCR/G Protein

Adenosine ReceptorAdiponectin ReceptorAngiotensin ReceptorBombesin ReceptorBradykinin ReceptorcAMPCannabinoid ReceptorCaSRCCRCGRP ReceptorCholecystokinin ReceptorCRTH2CXCRDopamine ReceptorEndothelin ReceptorGHSRGlucagon ReceptorGNRH ReceptorGPCRGuanylate CyclaseHedgehogHistamine ReceptorImidazoline ReceptorLPA ReceptorLPL ReceptorLTRmGluRMotilin ReceptorMT ReceptorNeuropeptide Y ReceptorNeurotensin ReceptorNK ReceptorNMUROX ReceptorP2Y ReceptorPAFRPARPKAProstaglandin ReceptorRasRGSSGLTSigma ReceptorSSTRTSH ReceptorUrotensin ReceptorVasopressin ReceptorHDRApelin ReceptorCRF ReceptorGPR88LHCGRMelanocortin ReceptorOXTRSPHK5-HT ReceptorAChRAdrenergic ReceptorGlucocorticoid ReceptorOpioid ReceptorSRPKGalRTAAREpacG proteinEndorphinSOS1/KRAS (stapled peptide)Rab (stapled peptide)SOSCalcitonin ReceptorSUCNR1FPRNeuropeptide S Receptor

Immunology/Inflammation

CCRComplement SystemCOXCRTH2CXCRFLAPHistamine ReceptorIFNARIL ReceptorIRAKLTRMALT1MyD88NADPH OxidaseNLRNOSNrf2PD-1/PD-L1PGE SynthaseROSSIKSTINGThrombopoietin ReceptorTLRLTA4HCalcineurinComplement ReceptorGM-CSFIFNILImmunology & Inflammation RelatedIRF3MIFS100A9THPOTSPOcGASmacrophage/microgliaNFATFPRCYPACD80Scavenger receptorNOTCD28-B7EndorphinLanC-like proteinPG SynthaseXBP1Complement C3VISTACD147PD-1 PD-L1/PROTACNETosisSAMHD1CD38Mast CellTim-3

JAK/STAT Signaling

EGFRJAKPimSTATEGFR/PROTACSTAT/PROTAC

LIF/Stat3

LIF

MAPK/ERK Pathway

ERKJNKKLFMEKMLKMNKp38 MAPKRafRSKCot/tpl2MAP3K12MAP4K4AP-1MK2MAP4K6

Membrane Transporter/Ion Channel

AMPARATPaseBCRPCalcium ChannelCFTRChloride ChannelCRAC ChannelCRM1EAAT2GABA ReceptorGlyT1HCN ChannelMATMCTNa+/Ca2+ ExchangerNa+/K+ ATPaseNBCNKCCNMDAROctP2X ReceptorP-gpPotassium ChannelProton PumpSGLTSodium ChannelTRPVURAT1VDACEAAT1IBATSV2TRP ChannelAChRSLCGlutamate transporterUCPENTGABA transporterGlycine transporterKainate receptorABC TransporterANTGluRAKK1Efflux pumpClathrinPiezoOCTNAQPVRACNPC1L1CD147Organic Anion TransporterARFOrai1
SLC6A19Ferroportin

Metabolic Enzyme

Adenosine DeaminaseAhRALDHAldose ReductaseAminopeptidaseATP Citrate LyaseCarbonic AnhydraseCathepsinCETPCOMTCPADecarboxylaseDehydrogenaseDGATDHFRElastaseEnolaseFAAHFABPFactor XaFASFerroptosisFXRGlucokinaseGLUT1GSNORGSTHexokinaseHIFHIV IntegraseHMGCRHSPHydroxylaseIDHIDOLipaseLipoxygenaseLXRMAOMineralocorticoid ReceptorNAENAMPTNeprilysinP450PAI-1PDEPDHKPGC-1αPhospholipaseProcollagen C ProteinaseRAR/RXRReninRORSCDSGKThioredoxinThrombinTransferaseVD/VDRXanthine OxidaseACMSDArginaseATP synthaseCholesterol TransporterCYP51Fumarate hydrataseGlucosidaseGlutaminase CGlyoxalaseKetohexokinaseLDLMitochondrial Electron Transport ChainMitochondrial MetabolismMPCPyruvate KinaseSteroid SulfataseTDOTGHTransketolaseαKGD15-PGDH3-PGDH5 Alpha ReductaseACATACCACEAdenosine KinaseAdenosylhomocysteinasePKM2PhosphorylaseGalactosidasesMetAPNPRPFKFBPaseACSD-amino acid oxidaseP448SrxAOProprotein convertasesAPOECarboxylesteraseCPSIGLUTQRsEHGPxG0/G1 switch protein 2GMPSCYPAPvdQ acylaseBDKCreatine kinaseNPPVDR (stapled peptide)AKRHMG-CoA synthaseRBPFTOD6DXBP1OGTNQOADP-ribosyltransferaseERAPLRH-1PASKPME-NMTPDE-NMTPEPCKCardiolipin PeroxidaseAconitate hydrataseAsparagine synthetaseSGK3/PROTACRAR/PROTACOPA1HydrolaseNNMT6PGDLOXBeta-glucuronidaseE-NTPDaseFPRAPOAMeprin βSQORGABA TransaminaseFACE1Homogentisate solanesyltransferase

Neuronal Signaling

AChEAMPARAmyloid-βCaMKCGRP ReceptorCOMTCOXDATDopamine ReceptorFAAHGABA ReceptorGlyT1Histamine ReceptorImidazoline ReceptorMAOmGluRMT ReceptorNK ReceptorNMDAROX ReceptorP2X ReceptorP-gpSecretaseSSRIsSubstance PCholineCholinesteraseEnkephalinaseGlucosylceramide SynthaseNETPSD-95RAGESERT5-HT ReceptorAA-amyloidAChRAdenosine KinaseAdrenergic ReceptorOpioid ReceptorQCTAARTLXCHTGABA transporterGlycine transporterKainate receptorGluREndorphinS100βRyanodine Receptor-1RESTSLC6A19α-Synuclein

PI3K/Akt/mTOR

AktAMPKATM/ATRDNA-PKGSK-3MELKmTORPDK-1PI3KPI4KPIKfyvePTENRSKFOXOPHLPPPDK

Protease

CaspaseCysteine ProteaseDPP4GlutaminaseHIV ProteaseMMPProteasomeSecretaseSer/Thr ProteaseTyrosinaseAspartic ProteaseNEPPE3CLproDPP2SUMODipeptidase 1ThermolysinSerine/Cysteine protease

Protein Tyrosine Kinase/RTK

Ack1ALKBMX KinaseBTKc-FMSc-Kitc-Met/HGFR
c-RETDDR1/DDR2 ReceptorDYRKEGFREphrin ReceptorFAKFGFRFLT3HER2IGF-1RInsulin ReceptorITKPDGFRPKAPTKPyk2Ros1SrcSykTAM ReceptorTie-2Trk ReceptorVEGFRBRKFLT4Bcr-AblMERTKFGFTecErbBBTK/PROTACFLT3-ITD/PROTACEGFR/PROTACGAKIGF2

TGF-beta/Smad

Bcr-AblPKCTGF-beta ReceptorTGF-betaSmadMARP

Stem Cells/Wnt

BMI-1Casein KinaseERKGliGSK-3HedgehogJAKMSTNotchPKAPORCNROCKSecretasesFRP-1SmoSTATWntYAPβ-catenin14-3-3CREBβ-catenin (stapled peptide)Notch (stapled peptide)PKA/AKAP (stapled peptide)LIN28MARPLRH-1STAT/PROTACNotumMAP4K6Frizzled-4

Ubiquitin

APCDUBE1/E2/E3 EnzymeNAEp97ProteasomeMDM2SUMOFBXOFunctionalized E3 Ligand (Bestatin)DCNUSP30

Phosphatase

NF-κB

HDACIKKMALT1NF-κBNrf2PPARRIP KinaseTAK1LUBACRIP Kinase/PROTACTBK/PROTAC

Biochemical Reagent

Intermediate and OthersBiochemical Assay ReagentDye ReagentCationic & Neutral LipidsDendrimersLNADenaturantsProtein Assay ReagentsProtein Modification ReagentsSubstratesElectrophoresis ReagentsLuminescent Reagents & Detection ReagentsBuffer ReagentsDetergentsColorimetric ReagentsDiagnostic ReagentsFluorescent DyeFluorescence LabelingChelating Agent

Stapled Peptide

Mcl-1 (stapled peptide)β-catenin (stapled peptide)EZH2 (stapled peptide)SOS1/KRAS (stapled peptide)Notch (stapled peptide)PKA/AKAP (stapled peptide)Beclin 1 (stapled peptide)Bim (stapled peptide)Bcl-2 (stapled peptide)p53/MDM2 (stapled peptide)RAP1/TRF2 (stapled peptide)Rab (stapled peptide)VDR (stapled peptide)β-arrestin/β-adaptin (stapled peptide)

Others

SRPKVDAAnestheticAntispasmodic AgentAnti-Thyroid AgentAnti-ulcerCancer Stem CellsCardiolipin PeroxidaseCD73CerKCholereticCholine KinaseDiureticE2FECEFANCJFAPFer/FerTFPP synthaseFucosyltransferaseFungicideGalectin-3GBF1GCaseHIPK2HPPDImportin βInsecticideITPKALAT1MITFMLKLMPOMPTPMTTPMuscle RelaxantNMDNO SynthesisNur77O-GlcNAcaseOsteoclasts/Bone/OsteogenesisOxPhosPAX2PBRPCSK9PDX1PFKFB3PhotosensitizerPIN1PKGPlateletPME-1PREPProtein SynthesisPXRRev-ErbASAPSpermine SynthaseSQSSREBPSweetenerTgaseTIR1TNKUGT1A1UreaseVaninXORCARLegumainOthers-OthersVitaminMicroRNANTGMPSATAD5PANKO-glycosylationDcpSGRKTNIKRUNXHRGP20-HETECardiac transcription factorAIMP2-DX2PAM complexIMP1Quorum SensingPhosphataseASGPRSMARCPU.1HNF4αPNAPMO/MNAVPSBBOXGTPCHFATPIKZF1IKZF2OSCGalectin-1OSBPLRACK1PC-TPTTBK1TREM1UGT8AntioxidantAntithrombinEndogenous MetaboliteDrug Impurities
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