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Smo
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20315 | Smo Inhibitor C24 | 1567963-99-8 | Smo inhibitor C24 is a tetrahydropyrido[4,3-d]pyrimidine derivative that represent a set of Smo inhibitors that could potentially be utilized to treat medulloblastoma and other Hh pathway related malignancies. |
| CSN16966 | SAG | 912545-86-9 | SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM. |
| CSN19210 | SAG hydrochloride | 2095432-58-7 | SAG HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
| CSN15983 | Purmorphamine | 483367-10-8 | Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. |
| CSN15911 | PF-5274857 | 1373615-35-0 | PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. |
| CSN13874 | Glasdegib | 1095173-27-5 | PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. |
| CSN23037 | PF-5274857 hydrochloride | 1613439-62-5 | PF 5274857 HCl is a high affinity and selective Smoothened (Smo) receptor antagonist with Ki of 4.6 nM. |
| CSN18669 | MK-4101 | 935273-79-3 | MK-4101 inhibits the hedgehog pathway with anti-tumor activity via the inhibition of proliferation and induction of apoptosis. |
| CSN16217 | Taladegib | 1258861-20-9 | LY2940680 can bind to the Smo receptor and inhibit hedgehog signaling. |
| CSN19814 | LEQ506 | 1204975-42-7 | LEQ506 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. |
| CSN16234 | Sonidegib | 956697-53-3 | LDE225 is an antagonist of Smoothened that can inhibit hedgehog signaling with IC50 of 2.5 nM. |
| CSN17578 | Sonidegib diphosphate | 1218778-77-8 | LDE225 diphosphate is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively. |
| CSN15980 | Jervine | 469-59-0 | Jervine is hedgehog signaling inhibitor with IC50 of 500 nM-700 nM that disrupts the interaction with smoothened. |
| CSN23089 | SANT 2 | 329196-48-7 | Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity |
| CSN22854 | IHR-1 | 548779-60-8 | IHR 1 is a potent Smo antagonist with IC50 of 7.6 nM. |
| CSN22839 | GSA-10 | 300833-95-8 | GSA 10 is a smoothened (Smo) receptor agonist with EC50 of 1.2 μM. |
| CSN10720 | Cyclopamine | 4449-51-8 | Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells. |
| CSN17174 | BMS-833923 | 1059734-66-5 | BMS-833923 is an inhibitor of Smoothened with potential antineoplastic activity. It can also inhibit BODIPY cyclopamine binding to SMO with IC50 of 21 nM. |
| CSN27774 | ALLO-2 | 1357350-60-7 | |
| CSN42894 | CUR61414 | 334998-36-6 | |
| CSN103384 | 2-(6-(4-(4-Benzylphthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol | 1057677-92-5 |
