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Sodium Channel

Sodium Channel

货号 产品名 CAS号 信息
CSN23212 Zoniporide 2HCl 241799-10-0 Selective NHE1 inhibitor
CSN27571 Ropivacaine mesylate 854056-07-8 Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN27570 Ropivacaine 84057-95-4 Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.
CSN24189 Rimeporide 187870-78-6 Rimeporide is a potent and selective NHE1 inhibitor.
CSN12787 Ranolazine 2HCl 95635-56-6 Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
CSN21963 Quinidine Sulfate 6591-63-5 Quinidine can act as a voltage-gated sodium channels blocker and an inhibitor of the cytochrome P450 enzymes 2D6/3A4. It is an antimuscarinic and antimalarial.
CSN18778 Proparacaine HCl 5875-06-9 Proparacaine HCl is an antagonist of voltage-gated sodium channels with ED50 of 3.4 mM.
CSN18533 PH-064 892546-37-1 PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry.
CSN21395 PF-06869206 2227425-05-8 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
CSN26169 PF-06305591 1449473-97-5 PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with IC50 of 15 nM. It shows excellent preclinical in vitro ADME and safety profile.
CSN26313 PF-01247324 875051-72-2 PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM.
CSN17076 Nicainoprol 76252-06-7 Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent.
CSN16914 Nav1.7 Inhibitor 1355631-24-1 Nav1.7 inhibitor is a sulfonamide derivative with potent Nav1.7 inhibition activity.
CSN21733 Micinicate 39537-99-0 Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current.
CSN27572 Mepivacaine 96-88-8 Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
CSN25458 Licarbazepine 29331-92-8 Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
CSN12998 Lamotrigine 84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN21301 FR183998 239440-20-1 FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
CSN21637 ETH2120 81686-22-8 ETH2120 is a Na+ ionophore suitable for the assay of sodium activity in blood.
CSN20530 Eniporide 176644-21-6 Eniporide is an inhibitor of Na+/H+ exchange that prevents ischemic Na+ overload.
CSN25462 EIPA 1154-25-2 EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CSN21438 Disopyramide 3737-09-5 Disopyramide can block sodium channel, it is a class IA antiarrhythmic drug.
CSN20559 Cariporide 159138-80-4 Cariporide is a selective inhibitor of Na+/H+ exchanger isoform 1 (NHE1) with IC50 value of 0.05 μM with cardioprotective and antiarrhythmic effects.
CSN18717 Benzocaine HCl 23239-88-5 Benzocaine HCl is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
CSN23800 Benzamil HCl 161804-20-2 Benzamil hydrochloride is a specific blocker of sodium channel (ENaC).
CSN16841 (-)-Sparteine 90-39-1 (-)-Sparteine is a class 1a antiarrhythmic agent and a sodium channel blocker.
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