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Sodium Channel
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25305 | Tenapanor | 1234423-95-0 | Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney, with IC50 values of 5 and 10 nM against human and rat NHE3, respectively. |
| CSN27571 | Ropivacaine mesylate | 854056-07-8 | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. |
| CSN27570 | Ropivacaine | 84057-95-4 | Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo. |
| CSN12787 | Ranolazine dihydrochloride | 95635-56-6 | Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina. |
| CSN26308 | Ralfinamide mesylate | 202825-45-4 | Ralfinamide mesylate is an blocker of Na+ channel with function of suppressing pain. |
| CSN24710 | Ralfinamide | 133865-88-0 | Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain . |
| CSN18533 | PH-064 | 892546-37-1 | PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry. |
| CSN26169 | PF-06305591 | 1449473-97-5 | PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with IC50 of 15 nM. It shows excellent preclinical in vitro ADME and safety profile. |
| CSN26313 | PF-01247324 | 875051-72-2 | PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM. |
| CSN26179 | N-Me-aminopyrimidinone 9 | 1356834-62-2 | N-Me-aminopyrimidinone 9 is an improved Nav1.7 antagonist with minimal off-target hERG liability, and improved rat PK properties. |
| CSN21733 | Nicotinoyl cyclandelate | 39537-99-0 | Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current. |
| CSN27572 | Mepivacaine | 96-88-8 | Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. |
| CSN13632 | Lidocaine | 137-58-6 | Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic. |
| CSN11299 | Lidocaine hydrochloride | 73-78-9 | Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic. |
| CSN25458 | Licarbazepine | 29331-92-8 | Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects. |
| CSN12632 | Lappaconitine | 32854-75-4 | Lappaconitine is a selective blocker of the TTX-sensitive Na+ channels without influence on the activation threshold of Na+ channels. It is an analgesic alkaloid isolated from Aconitum sinomontanum Nakai.. |
| CSN12998 | Lamotrigine | 84057-84-1 | Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition. |
| CSN21637 | Sodium ionophore III | 81686-22-8 | ETH2120 is a Na+ ionophore suitable for the assay of sodium activity in blood. |
| CSN25462 | EIPA | 1154-25-2 | EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
| CSN25620 | DSP-2230 | 1233231-30-5 | DSP-2230 is a selective Nav1.7/Nav1.8 blocker. |
| CSN51363 | AZ194 | 2241651-99-8 | CRMP2-Ubc9-NaV1.7 inhibitor 194 is a CRMP2-Ubc9-NaV1.7 inhibitor. |
| CSN32431 | Evenamide | 1092977-61-1 | |
| CSN32430 | Piromelatine | 946846-83-9 | |
| CSN40141 | Veratridine | 71-62-5 | |
| CSN41903 | Benzamil | 2898-76-2 | |
| CSN38648 | GNE-0439 | 1241902-40-8 | |
| CSN38350 | Nav1.1 activator 1 | 2332897-85-3 | |
| CSN33959 | Lu AE98134 | 849000-18-6 | |
| CSN35591 | AM-2099 | 1443373-17-8 | |
| CSN35584 | PF-04856264 | 1235397-05-3 | |
| CSN42120 | Cyfluthrin | 68359-37-5 | |
| CSN43403 | Nav1.7-IN-3 | 1788872-06-9 | |
| CSN43405 | GNE-616 | 2349371-81-7 | |
| CSN43828 | PF-05198007 | 1235406-19-5 | |
| CSN43402 | PF-05241328 | 1387633-03-5 | |
| CSN51358 | GX-674 | 1432913-36-4 | |
| CSN63043 | PF-05186462 | 1235406-03-7 | |
| CSN63066 | TC-N 1752 | 1211866-85-1 | |
| CSN63345 | Flecainide-d4 acetate | 1276197-21-7 | |
| CSN63457 | (R)-Funapide | 1259933-15-7 | |
| CSN64881 | S3969 | 1027997-01-8 | |
| CSN67373 | GX-201 | 1788071-27-1 | |
| CSN67713 | Idrevloride | 1416973-63-1 | |
| CSN67909 | GDC-0310 | 1788063-52-4 | |
| CSN75789 | NAV 26 | 1198160-14-3 | |
| CSN76031 | Nav1.8-IN-1 | 1026822-49-0 | |
| CSN78051 | ABBV-318 | 1802848-94-7 | |
| CSN79818 | Nav1.8-IN-2 | 2756250-30-1 | |
| CSN104104 | 1-Benzyl-5-methyl-1H-1,2,3-triazole-4-carboxamide | 924862-21-5 | |
| CSN51561 | 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide | 354812-16-1 |
