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Sodium Channel

Sodium Channel

货号 产品名 CAS号 信息
CSN23212 Zoniporide 2HCl 241799-10-0 Selective NHE1 inhibitor
CSN27571 Ropivacaine mesylate 854056-07-8 Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN27570 Ropivacaine 84057-95-4 Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.
CSN24189 Rimeporide 187870-78-6 Rimeporide is a potent and selective NHE1 inhibitor.
CSN24710 (S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide 133865-88-0 Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain .
CSN21963 Quinidine Sulfate 6591-63-5 Quinidine can act as a voltage-gated sodium channels blocker and an inhibitor of the cytochrome P450 enzymes 2D6/3A4. It is an antimuscarinic and antimalarial.
CSN18778 Proparacaine HCl 5875-06-9 Proparacaine HCl is an antagonist of voltage-gated sodium channels with ED50 of 3.4 mM.
CSN16780 Prilocaine 721-50-6 Prilocaine is a local anesthetic of the amino amide type.
CSN16772 Phenytoin Sodium 630-93-3 Phenytoin sodium is a stabilizer of inactive voltage-gated sodium channel.
CSN21395 PF-06869206 2227425-05-8 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
CSN16737 Oxcarbazepine 28721-07-5 Oxcarbazepine is a voltage-gated sodium channel blocker with IC50 of 160 μM and it is used for the treatment of partial seizure.
CSN17076 Nicainoprol 76252-06-7 Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent.
CSN27572 Mepivacaine 96-88-8 Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
CSN11299 Lidocaine HCl 73-78-9 Lidocaine HCl is antiarrhythmic agent and used as a local anesthetic.
CSN25458 Licarbazepine 29331-92-8 Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
CSN16268 Levobupivacaine HCl 27262-48-2 Levobupivacaine HCl is a local anaesthetic compound belonging to the amino amide group and a long-acting local anesthetic.
CSN18204 ICA-121431 313254-51-2 ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition on human, monkey and dog Nav1.7.
CSN21301 FR183998 239440-20-1 FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
CSN20530 Eniporide 176644-21-6 Eniporide is an inhibitor of Na+/H+ exchange that prevents ischemic Na+ overload.
CSN19026 Eleclazine HCl 1448754-43-5 Eleclazine HCl is a late Na+ current inhibitor with IC50 value of 0.7 μM.
CSN25462 EIPA 1154-25-2 EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CSN21438 Disopyramide 3737-09-5 Disopyramide can block sodium channel, it is a class IA antiarrhythmic drug.
CSN16789 Cinchocaine 85-79-0 Cinchocaine is amide type local anesthetic that is generally used for surface anesthesia.
CSN20559 Cariporide 159138-80-4 Cariporide is a selective inhibitor of Na+/H+ exchanger isoform 1 (NHE1) with IC50 value of 0.05 μM with cardioprotective and antiarrhythmic effects.
CSN16283 Carbamazepine 298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug.
CSN16674 Benzocaine 94-09-7 Benzocaine, the ethyl ester of p-aminobenzoic acid (PABA), inhibits voltage-dependent sodium channels (VDSCs) on the neuron membrane and used as a local anesthetic.
CSN18717 Benzocaine HCl 23239-88-5 Benzocaine HCl is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
CSN16841 (-)-Sparteine 90-39-1 (-)-Sparteine is a class 1a antiarrhythmic agent and a sodium channel blocker.
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