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SOS (and other guanine nucleotide exchange factors) act by binding Ras-GTPases and forcing them to release their bound nucleotide (usually GDP). Once released from SOS, the Ras-GTPase quickly binds fresh guanine nucleotide from the cytosol.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25298 | BI-3406 | 2230836-55-0 | BI-3406 is a SOS1 inhibitor with IC50 value of 6nM and it exhibits anticancer activity. |
| CSN24479 | BAY-293 | 2244904-70-7 | BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21nM. |
| CSN51365 | RMC-0331 | 2488788-52-7 | |
| CSN63089 | NSC-658497 | 909197-38-2 | |
| CSN75193 | MRTX0902 | 2654743-22-1 | |
| CSN108087 | 7-(2-Chlorophenyl)-3b,6,6a,7,9,9a,10,12a-octahydrocyclopenta[4,5]pyrido[3,2,1-ij]cyclopenta[c]quinoline-2-carboxylic acid | 487001-04-7 |
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