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SOS (and other guanine nucleotide exchange factors) act by binding Ras-GTPases and forcing them to release their bound nucleotide (usually GDP). Once released from SOS, the Ras-GTPase quickly binds fresh guanine nucleotide from the cytosol.

SOS

货号 产品名 CAS号 信息
CSN24479 BAY-293 2244904-70-7 BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21nM.
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