Sphingosine Kinase | Autophagy| CSNpharm

SPHK

SPHK
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货号	产品名	CAS号	信息
CSN18688	SKI II	312636-16-1	SKI II is an inhibitor of non ATP-competitive sphingosine kinase (SphK) with IC50 of 0.5 μM.
CSN23038	PF 543 HCl	1706522-79-3	PF-543 HCl is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
CSN17876	K145 HCl	1449240-68-9	K145 HCl is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
CSN24154	Defensamide	1104874-94-3	Defensamide is an activator of SPHK1, and significantly stimulates CAMP mRNA and protein production in KC.
CSN16869	ABC294640	915385-81-8	ABC294640 markedly alters the ratio of ceramide/S1P consistent with inhibition of SK activity in MDA-MB-231 cells.