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货号 产品名 CAS号 信息
CSN18688 SKI II 312636-16-1 SKI II is an inhibitor of non ATP-competitive sphingosine kinase (SphK) with IC50 of 0.5 μM.
CSN23038 PF 543 HCl 1706522-79-3 PF-543 HCl is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
CSN17876 K145 HCl 1449240-68-9 K145 HCl is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
CSN24154 Defensamide 1104874-94-3 Defensamide is an activator of SPHK1, and significantly stimulates CAMP mRNA and protein production in KC.
CSN16869 ABC294640 915385-81-8 ABC294640 markedly alters the ratio of ceramide/S1P consistent with inhibition of SK activity in MDA-MB-231 cells.
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