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货号 产品名 CAS号 信息
CSN20618 SKI-178 1259484-97-3 SKI-178 is an in vivo active non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM), which induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines.
CSN18688 SKI II 312636-16-1 SKI II is an inhibitor of non ATP-competitive sphingosine kinase (SphK) with IC50 of 0.5 μM.
CSN23038 PF 543 HCl 1706522-79-3 PF-543 HCl is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
CSN18116 MP-A08 219832-49-2 MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.
CSN17876 K145 HCl 1449240-68-9 K145 HCl is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
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