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Src

Src

货号 产品名 CAS号 信息
CSN15826 ZM 306416 690206-97-4 ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively.
CSN16229 WH-4-023 837422-57-8 WH-4-023 is an inhibitor of Lck and Src with IC50 of 2 nM, 6 nM, respectively.
CSN17744 WEHI-345 analog 1354825-62-9 WEHI-345 analog is a Src inhibitor.
CSN20579 Repotrectinib 1802220-02-5 TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
CSN13096 TG 100801 867331-82-6 TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src family kinases with IC50 values of 2/7/2/1/0.5 nM of VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
CSN18504 TG 100572 867334-05-2 TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
CSN18503 TG 100572 Hydrochloride 867331-64-4 TG 100572 HCl is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
CSN17735 T338C Src-IN-2 1351927-00-8 T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM and also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.
CSN17734 T338C Src-IN-1 1351926-90-3 T338C Src-IN-1 is a potent mutant-Src T338C inhibitor and exhibits the most potent inhibition of T338C (IC50=111 nM) relative to WT c-Src(10-fold increase).
CSN18218 SU6656 330161-87-0 SU 6656 is an inhibitor of Src kinases and can target Src, Yes, Lyn, and Fyn with IC50 of 280 nM, 20 nM, 130 nM, 170 nM, respectively.
CSN17355 Src Inhibitor 1 179248-59-0 Src inhibitor 1 is an inhibitor of Src and Lck with IC50 of 44 nM and 88nM.
CSN23720 RK-24466 213743-31-8 RK-24466 is an inhibitor of Lck (64-509) and LckCD isoforms with IC50s of <2 nM.
CSN21067 Ponatinib hydrochloride 1114544-31-8 Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively.
CSN23025 PD0166285 dihydrochloride 212391-63-4 PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively.
CSN16663 NVP-BHG712 940310-85-0 NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition and also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
CSN12108 Tolimidone 41964-07-2 MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
CSN17507 MCB-613 1162656-22-5 MCB-613 is a stimulator of steroid receptor coactivator (SRC).
CSN16563 Lck Inhibitor 847950-09-8 Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.
CSN18620 Lck inhibitor 2 944795-06-6 Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively.
CSN18935 Tirbanibulin Mesylate 1080645-95-9 KX2-391 mesylate is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
CSN16540 Tirbanibulin 897016-82-9 KX2-391 is an inhibitor of Src with IC50 of 9 nM-60 nM in cancer cells. It is the first clinical and peptidomimetic class Src inhibitor.
CSN16378 Tirbanibulin dihydrochloride 1038395-65-1 KX2-391 2HCl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
CSN13760 KX1-004 518058-84-9 KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.
CSN11250 Kenpaullone 142273-20-9 Kenpaullone is an ATP-competitive inhibitor of CDK1/cyclin B (IC50 = 0.4 µM), CDK2/cyclin A (IC50 = 0.68 µM), CDK5/p25 (IC50 = 0.85 µM), lymphocyte kinase (IC50 = 0.47 µM) , and GSK-3β (C50 = 0.23 μM).
CSN19857 KB SRC 4 1380088-03-8 KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM) and does not inhibit c-Abl at concentrations up to 125 μM.
CSN25623 Hck-IN-1 1473404-51-1 Hck Blocker compound B9 is a Nef-dependent Hck blocker with IC50 value of 2.8μM for Nef-Hck complex but >20μM for Hck alone. It binds directly to Nef via a pocket formed by the Nef dimerization interface and disrupts Nef dimerization in cells.
CSN27682 DGY-06-116 2556836-50-9 DGY-06-116 is an irreversible covalent and selective Src inhibitor.
CSN16497 Dasatinib 302962-49-8 Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.
CSN27592 CH6953755 2055918-71-1 CH6953755 is a selective inhibitor of YES1 kinase with IC50 of 1.8 nM.
CSN18293 AZM475271 476159-98-5 AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM showing no inhibitory activity on Flt3, KDR, Tie-2.
CSN17121 AMG-47a 882663-88-9 AMG-47a is a Lck inhibitor that can decrease T cell proliferation with anti-inflammatory activity.
CSN18243 A 419259 364042-47-7 A 419259 is an apoptosis inducing agent that inhibits Src family kinases (c-Src) and also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation.
CSN17856 A 419259 trihydrochloride 1435934-25-0 A 419259 3HCl is a broad-spectrum pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family with IC50 of 9 nM, < 3 nM and < 3 nM for Src, Lck and Lyn, respectively.
CSN21118 7-Hydroxy-4H-chromen-4-one 59887-89-7 7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM.
CSN13856 1-Naphthyl PP1 221243-82-9 1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).
CSN15753 1-Naphthyl PP1 hydrochloride 956025-47-1 1-Naphthyl PP1 HCl is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).
CSN26939 HG-7-85-01 1258391-13-7
CSN28978 4-Chloro-5-(1H-indol-3-yl)oxazole 120191-51-7
CSN39056 SM1-71 2088179-99-9
CSN40473 Herbimycin A 70563-58-5
CSN35548 Dasatinib metabolite M6 910297-53-9
CSN43294 eCF506 1914078-41-3
CSN42896 AZD0424 692054-06-1
CSN79676 CHMFL-ABL-053 1808287-83-3
CSN79705 N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide 897016-26-1
CSN78620 DC-Srci-6649 1037545-61-1
CSN83349 Bosutinib hydrate 918639-08-4
CSN107425 3-((6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)benzoic acid 185039-99-0
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