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SREBP

货号 产品名 CAS号 信息
CSN14080 Pseudoprotodioscin 102115-79-7 Pseudoprotodioscin shows a weaker suppressing effect on the production of inflammatory cytokines and can suppress melanogenesis in B16F1 cells. It's a natural product isolated and purified from the rhizomes of Dioscorea nipponica Makino. with moderate cytotoxicity.Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
CSN16616 Praeruptorin D 73069-28-0 Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.
CSN38450 PF429242 2HCl 2248666-66-0 PF429242 2HCl is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with IC50 value of 175nM.
CSN13748 Fatostatin Hydrobromide 298197-04-3 Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
CSN19276 Fatostatin 125256-00-0 Fatostatin A is an inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cells.
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