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STAT
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN10157 | Stattic | 19983-44-9 | Stattic, a nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. |
| CSN20442 | STAT5 Inhibitor | 285986-31-4 | STAT5 inhibitor suppresses STAT5 via interaction of its SH2 domain with IC50 of 47 µM. |
| CSN27573 | STAT3-IN-7 | 1313019-65-6 | STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects. |
| CSN27227 | STAT3-IN-1 | 2059952-75-7 | STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis . |
| CSN19875 | Saikosaponin D | 20874-52-6 | Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system. |
| CSN15990 | S3I-201 | 501919-59-1 | S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5. |
| CSN11557 | Nifuroxazide | 965-52-6 | Nifuroxazide suppresses the transcription activity of STAT1, STAT3 (IC50 = 3 μM in cells) and STAT5. It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections. |
| CSN12693 | Niclosamide | 50-65-7 | Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5). |
| CSN18451 | Napabucasin | 83280-65-3 | Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3. |
| CSN20515 | inS3-54-A18 | 328998-53-4 | inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth, metastasis and the expression of STAT3 target genes. |
| CSN19012 | HO-3867 | 1172133-28-6 | HO-3867 selectively inhibits the phosphorylation and transcription of STAT3. It is an analog of curcumin. |
| CSN16361 | Cryptotanshinone | 35825-57-1 | Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM. |
| CSN27216 | Colivelin TFA | N/A | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury . |
| CSN20212 | C188-9 | 432001-19-9 | C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice. |
| CSN14698 | Brevilin A | 16503-32-5 | Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). |
| CSN17200 | BP-1-102 | 1334493-07-0 | BP-1-102 is an orally available, small-molecule inhibitor of transcription factor STAT3. |