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STAT

STAT

货号 产品名 CAS号 信息
CSN20470 STX-0119 851095-32-4 STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation.
CSN20442 STAT5-IN-1 285986-31-4 STAT5 inhibitor suppresses STAT5 via interaction of its SH2 domain with IC50 of 47 µM.
CSN27573 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 1313019-65-6 STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects.
CSN27227 STAT3-IN-1   2059952-75-7 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis .
CSN32601 1-Acetyl-5-hydroxyanthracene-9,10-dione 63972-38-3 STAT3 Inhibitors, Signal Transduction Modulators
CSN32584 Fluacrypyrim 229977-93-9 STAT3 Inhibitors, Signal Transduction Modulators
CSN19288 Stafib-1 1688703-26-5 Stafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner.
CSN19226 Ochromycinone 111540-00-2 STA-21 is a selective STAT3 inhibitor.
CSN22560 SH5-07 1456632-41-9 SH5-07 is an inhibitor of STAT3 with IC50 of 3.9±0.6 μM with antitumor effects and it can suppresse human glioma and breast cancer.
CSN17881 SH-4-54 1456632-40-8 SH-4-54 is a potent, small molecule, nonphosphorylated STAT3 inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
CSN28525 SD-36 2429877-44-9 SD-36 is a PROTAC Degrader of STAT3 Protein. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules.
CSN19875 Saikosaponin D 20874-52-6 Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system.
CSN15990 NSC 74859 501919-59-1 S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5.
CSN11557 Nifuroxazide 965-52-6 Nifuroxazide suppresses the transcription activity of STAT1, STAT3 (IC50 = 3 μM in cells) and STAT5. It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections.
CSN12693 Niclosamide 50-65-7 Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5). It is also an antiparasitic agent. It induced apoptosis by activating the intrinsic and caspase-independent pathway in human A549 and CL1-5 cells.
CSN18451 Napabucasin 83280-65-3 Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3.
CSN20515 inS3-54A18 328998-53-4 inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth, metastasis and the expression of STAT3 target genes.
CSN19012 HO-3867 1172133-28-6 HO-3867 selectively inhibits the phosphorylation and transcription of STAT3. It is an analog of curcumin.
CSN22552 HJC0152 hydrochloride 1420290-99-8 HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner.
CSN22827 Galiellalactone 133613-71-5 Galiellalactone is a STAT3 inhibitor that irreversibly binds STAT3 and inhibits binding to DNA.
CSN16361 Cryptotanshinone 35825-57-1 Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.
CSN14607 Corylifol A 775351-88-7 Corylifol A is a phenolic compounds isolated from Psoralea corylifolia and inhibits IL-6-induced STAT3 activation and phosphorylation (IC50=0.8 μM).
CSN27216 Colivelin TFA 2803948-60-7 Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .
CSN23522 Colivelin 867021-83-8 Colivelin is a peptide and activator of STAT3 with neuroprotective effects.
CSN20212 C188-9 432001-19-9 C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice.
CSN14698 Brevilin A 16503-32-5 Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
CSN17200 BP-1-102 1334493-07-0 BP-1-102 is an orally available, small-molecule inhibitor of transcription factor STAT3.
CSN15925 Balsalazide sodium hydrate 150399-21-6 Balsalazide Disodium is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN28449 Danvatirsen 1402357-06-5 AZD9150 is an antisense oligonucleotide inhibitor of STAT3.
CSN13598 AS1517499 919486-40-1 AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
CSN32585 (+)-Ochromycinone 28882-53-3 Apoptosis Inducers, STAT3 Inhibitors, Signal Transduction Modulators
CSN32598 Tetramethylcurcumin 52328-97-9 Apoptosis Inducers, STAT3 Inhibitors, Signal Transduction Modulators
CSN13724 AG490 133550-30-8 AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 = 2 μM), ErbB2 (IC50 = 13.5 μM), STAT3 and JAK2.
CSN40263 Oleoylcarnitine 38677-66-6
CSN39779 STAT3-IN-3 2361304-26-7
CSN35028 STAT5-IN-2 2111834-61-6
CSN42294 4-Bromo-2-(3-(4-chlorophenyl)acryloyl)-7-(methylamino)cyclohepta-2,4,6-trienone 723746-47-2
CSN62721 Stafib-2 2097938-74-2
CSN67704 YM-341619 643082-52-4
CSN67451 Stafia-1-dipivaloyloxymethyl ester 2582755-72-2
CSN75532 MM-206 1809581-87-0
CSN79799 methyl Na-(((3,5-bis(trifluoromethyl)phenyl)carbamoyl)-L-valyl)-Nt-methyl-L-histidinate 1360562-98-6
CSN79825 ((((4-((8-methylnonanamido)methyl)-1,2-phenylene)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate) 1818390-58-7
CSN80455 4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid 1803281-30-2
CSN83112 IST5-002 13484-66-7
CSN86021 (S)-PM-43I 1637532-77-4
CSN103994 5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide 1260247-42-4
CSN105237 (S)-2-((S)-2-(4-Cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanamido)-4-methylpentanoic acid 725233-55-6
CSN104638 N1-(11H-Indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine 401463-02-3
CSN51563 (R)-2-Amino-3-(prop-2-yn-1-ylthio)propanoic acid 3262-64-4
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