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Steroids

Steroids

货号 产品名 CAS号 信息
CSN17211 α-Estradiol 57-91-0 α-Estradiol is an endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
CSN20659 Withanolide D 30655-48-2 Withanolide D is a steroidal lactone isolated from Withania somnifera which exhibits similar cytostatic effect in drug-resistant and drug-sensitive multiple myeloma cells.
CSN19989 Timosaponin BII 136656-07-0 Timosaponin BII, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with antioxidant and anti-dementia activities, can inhibit the up-regulation of BACE1 and reduced the over-production of β-CTF and Aβ in rat retina, which was induced by FeCl3, and may be useful for the treatment of type 2 diabetes.
CSN16341 Timosaponin A3 41059-79-4 Timosaponin A3, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge, triggers liver injury through inducing ROS generation and suppressing the expression of BA transporters.
CSN16895 Tigogenin 77-60-1 Tigogenin, a natural product isolated and purified from the herbs of Agave sisalana Perrine, induces apoptosis, associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2, and may modulate differentiation of BMSCs to cause a lineage shift away from the adipocytes and toward the osteoblasts, which is at least mediated by inhibition of PPARgamma and via p38 MAPK pathway.
CSN16105 Sarsasapogenin 126-19-2 Sarsasapogenin, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with anti-inflammatory, anti-diabetes,antidepressant, antitumor and protective effects, against glutamate-induced neurotoxicity in the cultured cortical neurons in rats, can improve memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models, and effectively promote the proliferation, differentiation and mineralization of osteoblasts cultured in vitro, also inhibit the generation of osteoclasts from marrow cells.
CSN16105 Sarsasapogenin 126-19-2 Sarsasapogenin, a natural product isolated and purified from the rhizomes of Anemarrhena asphodeloides Bunge with anti-inflammatory, anti-diabetes,antidepressant, antitumor and protective effects, against glutamate-induced neurotoxicity in the cultured cortical neurons in rats, can improve memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models, and effectively promote the proliferation, differentiation and mineralization of osteoblasts cultured in vitro, also inhibit the generation of osteoclasts from marrow cells.
CSN19963 Ruscogenin 472-11-7 Ruscogenin, a natural product isolated and purified from the root of Ophiopogon japonicus with significant anti-inflammatory and anti-thrombotic activities, significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, protects the brain against ischemic damage caused by middle cerebral artery occlusion (MCAO) which may be through downregulation of NF-κB-mediated inflammatory responses, inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways, and may attenuate high-fat diet (HFD)-induced steatohepatitis through downregulation of NF- κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway.
CSN19433 Resibufogenin 465-39-4 Resibufogenin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, displays great potential as a chemotherapeutic agent in oncology.
CSN19990 Polyphyllin VI 55916-51-3 Polyphyllin VI, a natural product isolated and purified from the rhizomes of Paris yunnanensis Franch. with hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy and sperm-killing effects.
CSN20178 Mogroside IIIE 88901-37-5 Mogroside IIIE a naturally occuring cucurbitane glycoside which can attenuate gestational diabetes mellitus through activating of AMPK signaling pathway in mice.
CSN19957 Liriope Muscari Baily Saponins C 87480-46-4 Liriope muscari baily saponins C, a natural product isolated and purified from the roots of Liriope muscari, has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.
CSN19362 Hecogenin 467-55-0 Hecogenin is a natural product isolated and purified from the roots of Aconitum carmichaeli Debx with antioxidant and anti-inflammatory properties, which can protect gastro by K⁺(ATP) channels opening and the COX-2/PG pathway.
CSN16894 Gitogenin 511-96-6 Gitogenin, a natural product isolated and purified from the herbs of Agave americana, is a selective inhibitor of UGT1A4, and does not inhibit the activities of major human CYP isoforms. Gitogenin is also an inhibitor of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively, and shows moderate stimulation of release activity on growth hormone from rat pituitary cells.
CSN19436 Gamabufotalin 465-11-2 Gamabufotalin, a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect.
CSN19485 Dioscin 19057-60-4 Dioscin, a natural product isolated and purified from the rhizome of Dioscorea Zingiberensis C.H.Wright, is a potent ITGA5 inhibitor, showing potent anti-cancer effect against a variety of tumor cell lines.
CSN18260 Desacetylcinobufagin 4026-95-3 Desacetylcinobufagin is a natural compound used for microbial transformation.
CSN19954 Cyasterone 17086-76-9 Cyasterone is an inhibitor of EGFR that maybe a promising anti-cancer agent espcially in skin carcinoma.
CSN19441 Cinobufagin 470-37-1 Cinobufagin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway, can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue, and act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.
CSN19995 Chonglou Saponin VII 68124-04-9 Chonglou saponin VII, a natural product isolated and purified from the roots of Paris polyphylla, shows inhibitory effects on cell proliferation.
CSN19035 Chenodeoxycholic Acid 474-25-9 Chenodeoxycholic acid is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines.
CSN19435 Bufalin 465-21-4 Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su and has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro.
CSN18282 Arenobufagin 464-74-4 Arenobufagin is a natural bufadienolide from toad venom and has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.
CSN20272 27-Hydroxycholesterol 20380-11-4 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
CSN19445 20-Hydroxyecdysone 5289-74-7 20-Hydroxyecdysone is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.
CSN17032 20(S)-Ginsenoside Rh2 67400-17-3 20(S)-ginsenoside Rh2 is a natural product isolated and purified from the root of Panax ginseng C. A. Mey.
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