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STING
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN23755 | STING ligand-1 | 2365039-41-2 | STING ligand-1 is a lead STING ligand with IC50 of 68 nM for HAQ STING. |
| CSN24506 | STING agonist-3 | 2138299-29-1 | STING agonist-3 is a selective small-molecule STING agonist which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
| CSN18399 | STING agonist-1 | 702662-50-8 | STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. |
| CSN27270 | SR-717 | 2375421-09-1 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity . |
| CSN29565 | SN-011 | 2249435-90-1 | SN-011 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. SN-011 is a demethyl analogue of DUN99845. |
| CSN16863 | ADU-S100 | 1638241-89-0 | ML RR-S2 CDA is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes). |
| CSN19006 | ADU-S100 ammonium salt | 1638750-96-5 | ML RR-S2 CDA ammonium is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles. |
| CSN29564 | SN-001 | 727699-84-5 | DUN99845 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. |
| CSN23276 | diABZI STING agonist-1 (Tautomerism) | 2138498-18-5 | diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
| CSN18324 | c-di-AMP | 54447-84-6 | Cyclic-di-AMP is a second messenger molecule produced in bacteria but not in mammals and can induce a strong immune response in vitro and in vivo. |
| CSN27873 | ChX710 | 2438721-44-7 | ChX710 can boost cellular response to cytosolic DNA via STING. It efficiently primed cellular response to transfected plasmid DNA as assessed by potent synergistic effects on IFN-β secretion and ISG expression levels. |
| CSN18467 | cGAMP | 849214-04-6 | cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity. |
| CSN22894 | CCCP | 555-60-2 | CCCP can inhibit the activation of STING and is widely used as a protonophore uncoupling agent for oxidative phosphorylation. CCCP is the most commonly used inducer of mitophagy in mammalian cells and is thought to exert its effects by reducing the mitochondrial membrane potential. |
| CSN23535 | C-178 | 329198-87-0 | C-178 is a STING inhibitor that can block palmitoylation (PMA)-induced clustering of STING. |
| CSN22907 | C-176 | 314054-00-7 | C-176 is a STING inhibitor with anti-inflammatory effection. |
| CSN26922 | 2',3'-cGAMP | 1441190-66-4 | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1]. |
| CSN23676 | H-151 | 941987-60-6 | 1-(4-Ethylphenyl)-3-(1H-indol-3-yl)urea, also known as H-151, is a irreversible inhibitor of STING that can inhibit the type I interferon (IFN) response and reduce the phosphorylation of TBK1 and palmitoylation of human STING in vitro. |
| CSN38578 | cGAMP disodium | 2407516-83-8 | |
| CSN34985 | STING agonist-4 | 2138300-40-8 | |
| CSN42704 | diABZI STING agonist-1 | 2138299-33-7 | |
| CSN43448 | CL656 | 1951464-79-1 | |
| CSN60003 | SR-717 free acid | 2375420-34-9 | |
| CSN50645 | STING agonist-4 TFA | 2138300-41-9 | |
| CSN50642 | STING agonist-20 | 2591300-72-8 | |
| CSN50644 | (S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide | 2248444-14-4 | |
| CSN50646 | E7766 diammonium salt | 2242635-03-4 | |
| CSN50643 | Oxoacridinylacetic acid derivatived STING agonist | 2332803-59-3 | |
| CSN50641 | diABZI STING agonist 4 | 2591300-74-0 | |
| CSN50648 | BNBC | 55171-63-6 | |
| CSN50647 | STING Agonist C11 | 875863-22-2 | |
| CSN62640 | STING-IN-2 | 346691-38-1 | |
| CSN67865 | STING-IN-3 | 2244881-69-2 | |
| CSN74760 | 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide | 2247732-89-2 | |
| CSN85029 | STING agonist-12 | 2259624-71-8 | |
| CSN85113 | STING agonist-10 | 2259308-69-3 | |
| CSN85217 | STING agonist-11 | 2259308-68-2 | |
| CSN86641 | STING agonist-16 | 652142-94-4 | |
| CSN91562 | BSP16 | 2727249-47-8 |
