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Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene. The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN24073 | Khs-101 | 1262770-73-9 | KHS101 is a selective inducer of neuronal differentiation. It induced neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM), suppressed astrocyte formation, and also induced acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo. |
| CSN24074 | KHS101 hydrochloride | 1784282-12-7 | KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3). |
| CSN25666 | BO-264 | 2408648-20-2 | BO-264 is a highly TACC3 inhibitor with IC50 value of 188nM. It significantly decreased centrosomal TACC3 during both mitosis and interphase, as well as displayed potent anti-proliferative activity (~90% have less than 1μM GI50 value) in the NCI-60 cell line panel compromising nine different cancer types. |
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