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Transforming Growth Factor beta (TGFβ) Receptor

TGF-beta Receptor

货号 产品名 CAS号 信息
CSN16619 SD-208 627536-09-8 SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM) and displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively.
CSN16734 SB-505124 694433-59-5 SB505124 is an inhibitor of TGFβ receptor for ALK4 (IC50 = 129 nM) and ALK5 (IC50 = 47 nM). It can also inhibit ALK7.
CSN11900 SB-431542 301836-41-9 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases.
CSN18520 R268712 879487-87-3 R268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
CSN15840 ML347 1062368-49-3 ML347 is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM and shows > 300-fold selectivity for ALK2 vs. ALK3.
CSN11348 LY364947 396129-53-6 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFβR-II.
CSN17852 LDN-212854 1432597-26-6 LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification.
CSN13848 LDN-193189 1062368-24-4 LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN13849 LDN-193189 HCl   1062368-62-0 LDN-193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN15921 K02288 1431985-92-0 K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively.
CSN13159 GW788388 452342-67-5 GW788388 is a selective ALK5 inhibitor with IC50 of 18 nM and also inhibits TGF-β type II receptor and activin type II receptor.
CSN17559 DMH-1 1206711-16-1 DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/< 5 nM for ALK1/2/3 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2.
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