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Transforming Growth Factor beta (TGFβ) Receptor

TGF-beta Receptor

货号 产品名 CAS号 信息
CSN16619 SD-208 627536-09-8 SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM) and displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively.
CSN16734 SB-505124 694433-59-5 SB505124 is an inhibitor of TGFβ receptor for ALK4 (IC50 = 129 nM) and ALK5 (IC50 = 47 nM). It can also inhibit ALK7.
CSN11900 SB-431542 301836-41-9 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases.
CSN13435 SB 525334 356559-20-1 SB-525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
CSN13732 SB-505124 hydrochloride 356559-13-2 SB-505124 HCl is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
CSN12299 RepSox   446859-33-2 RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
CSN18520 R-268712 879487-87-3 R268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
CSN26776 PF-06952229 1801333-55-0 PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer.
CSN15840 ML347 1062368-49-3 ML347 is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM and shows > 300-fold selectivity for ALK2 vs. ALK3.
CSN11348 LY-364947 396129-53-6 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFβR-II.
CSN13685 Galunisertib 700874-72-2 LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay.
CSN13478 LY2109761 700874-71-1 LY2109761 is a selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2.
CSN13876 LDN-214117 1627503-67-6 LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM with > 100 fold selectivity for ALK5, and also inhibits BMP6 (IC50=100 nM).
CSN17852 LDN-212854 1432597-26-6 LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification.
CSN13848 LDN193189 1062368-24-4 LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN13849 LDN-193189 HCl   1062368-62-0 LDN-193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN22554 LDN-193189 2HCl 1435934-00-1 LDN-193189 2HCl is a potent and selective ALK2 and ALK3 inhibitor.
CSN15921 K02288 1431985-92-0 K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively.
CSN13159 GW788388 452342-67-5 GW788388 is a selective ALK5 inhibitor with IC50 of 18 nM and also inhibits TGF-β type II receptor and activin type II receptor.
CSN15909 Vactosertib 1352608-82-2 EW-7197 is a selective inhibitor of TGF-β receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM.
CSN22227 Vactosertib Hydrochloride 1352610-25-3 EW-7197 HCl is a small-molecule ATP-competitive inhibitor of TGFβRI (ALK5) with an IC50 of 12.9 nM.
CSN17559 DMH-1 1206711-16-1 DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/< 5 nM for ALK1/2/3 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2.
CSN27624 BMS-986260 2001559-19-7 BMS-986260 is a potent, selective, and orally bioavailable TGFβR1 inhibitor, with IC50 of 1.6 nM.
CSN19475 A 77-01 607737-87-1 A77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
CSN24277 A 83-01 sodium salt 2828431-89-4 A 83-01 Sodium Salt is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively.
CSN13090 A 83-01 909910-43-6 A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively.
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