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Thymidylate Synthase

Thymidylate Synthase

货号 产品名 CAS号 信息
CSN10505 Trifluorothymidine 70-00-8 Trifluorothymidine is a derivative of thymidine that can inhibit thymidylate synthase and lead to DNA damage and apoptosis. It could be used to treat colorectal cancer.
CSN11829 Raltitrexed 112887-68-0 Raltitrexed is an inhibitor of thymidylate synthase with IC50 of 9 nM in L1210 cell.
CSN26506 Nolatrexed HCl 152946-68-4 Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Hence, it does not warrant further study as a single agent for this disease.
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