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Tie-2

Tie-2

货号 产品名 CAS号 信息
CSN16555 Tie2 kinase inhibitor 1 948557-43-5 Tie2 kinase inhibitor is an optimized compound of SB-203580, selective to Tie2 with IC50 of 0.25 μM, 200-fold more potent than p38.
CSN26565 GW768505A 501693-25-0 GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。
CSN15710 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 849217-68-1 Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
CSN22221 BAY-826 1448316-08-2 BAY-826 is a selective and potent TIE-2 inhibitor with Kdof 1.6 nM, respectively.
CSN90065 Nesvacumab 1296818-77-3
CSN51566 Tie2 kinase inhibitor 2 1020412-97-8
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