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TLR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20478 | TLR2-IN-C29 | 363600-92-4 | TLR2-IN-C29 is an inhibitor of TLR2. |
| CSN27285 | TH 1020 | 1841460-82-9 | TH1020 is Toll-like receptor (TLR) 5/Flagellin complex antagonist with IC50 of 0.85 μM. TH1020 competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion. |
| CSN15947 | TAK-242 | 243984-11-4 | TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
| CSN21096 | CU-CPT22 | 1416324-85-0 | Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β. |
| CSN12798 | Resiquimod | 144875-48-9 | Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities. |
| CSN11744 | Polyinosinic Acid-Polycytidylic Acid | 24939-03-5 | Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. |
| CSN22182 | PF-4878691 | 532959-63-0 | PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist. |
| CSN21351 | MD2-IN-1 | 111797-22-9 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2). |
| CSN18539 | Imiquimod Maleate | 896106-16-4 | Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN13134 | Imiquimod | 99011-02-6 | Imiquimod is an agonist of toll-like receptor 7 with EC50 of 2.1 µM that has antiviral and antitumor activities. It is commonly used to treat warts and anal areas. |
| CSN18646 | Imiquimod HCl | 99011-78-6 | Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN24299 | IAXO-102 | 1115270-63-7 | IAXO-102 is a novel small molecule TLR4 antagonist. |
| CSN25649 | Hydroxychloroquine | 118-42-3 | Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN20270 | G2013 | 1986-15-8 | G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells. |
| CSN17582 | E-6446 | 1219925-73-1 | E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. |
| CSN17716 | E-6446 2HCl | 1345675-25-3 | E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM. |
| CSN21261 | CU-CPT-9a | 2165340-32-7 | CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM. |
| CSN21226 | CU-CPT-8m | 125079-83-6 | CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis. |
| CSN22764 | CL 075 | 256922-53-9 | CL 075 is a TLR8 agonist. |
| CSN22734 | C34 | 40592-88-9 | C34 is a TLR4 inhibitor. |
| CSN25419 | Bropirimine | 56741-95-8 | Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract. |
