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TLR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN42212 | VB-201 | 630112-41-3 | VB-201 is a Toll-like receptor-2 (TLR-2) antagonist. |
| CSN20478 | TLR2-IN-C29 | 363600-92-4 | TLR2-IN-C29 is an inhibitor of TLR2. |
| CSN27285 | TH 1020 | 1841460-82-9 | TH1020 is Toll-like receptor (TLR) 5/Flagellin complex antagonist with IC50 of 0.85 μM. TH1020 competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion. |
| CSN26372 | Robinin | 301-19-9 | Robinin is flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4 and ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway[1]. |
| CSN19974 | Polygalasaponin F | 882664-74-6 | Polygalasaponin F, a natural product isolated and purified from the herbs of Polygala japonica Houtt. |
| CSN27297 | Pam3CSK4 | 112208-00-1 | Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2 . |
| CSN21351 | MD2-IN-1 | 111797-22-9 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2). |
| CSN26358 | 7-Allyl-78-dihydro-8-oxoguanosine | 121288-39-9 | Loxoribine, a guanosine analog, is selective agonist of Toll-like receptor 7 with anti-viral and anti-tumor activities. |
| CSN24299 | IAXO-102 | 1115270-63-7 | IAXO-102 is a novel small molecule TLR4 antagonist. |
| CSN25649 | Hydroxychloroquine | 118-42-3 | Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN20270 | G2013 | 1986-15-8 | G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells. |
| CSN21226 | CU-CPT-8m | 125079-83-6 | CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis. |
| CSN22764 | CL 075 | 256922-53-9 | CL 075 is a TLR8 agonist. |
| CSN22734 | C34 | 40592-88-9 | C34 is a TLR4 inhibitor. |
| CSN25419 | Bropirimine | 56741-95-8 | Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract. |
| CSN28448 | AT791 | 1219962-49-8 | AT791 inhibits TLR7/9 signaling in a variety of human and mouse cell types and inhibit DNA-TLR9 interaction in vitro. It suppresses responses to challenge doses of CpG–containing DNA. |
| CSN22347 | AN-3485 | 1213827-99-6 | AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. |
| CSN38026 | AXC-715 3HCl | 2490497-93-1 |
