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TNF-alpha

TNF-alpha

货号 产品名 CAS号 信息
CSN15856 VGX-1027 6501-72-0 VGX-1027 is an orally active immunomodulatory agent that primarily targets macrophages, it can inhibit TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. VGX-1027 also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ.
CSN22521 TNF-α-IN-1 444287-49-4 TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.
CSN12073 Thalidomide 50-35-1 Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects.
CSN51354 SM-7368 380623-76-7 SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner.
CSN23727 S-99 1124381-69-6 S-99 is an inhibitor of LPS-induced TNFalpha release.
CSN11309 Roquinimex 84088-42-6 Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha.
CSN21166 R-7050 303997-35-5 R-7050 is an antagonist of tumor necrosis factor receptor (TNFR) that towards TNFα.
CSN12289 QNZ 545380-34-5 QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN13185 Pomalidomide   19171-19-8 Pomalidomide can inhibit LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
CSN15896 PF-3644022 1276121-88-0 PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.
CSN22471 Nedocromil sodium 69049-74-7 Nedocromil Sodium is a potent TNF-α inhibitor with an IC50 value of 1.67 μM for Blood eosinophils.
CSN18474 Necrostatin 2 S enantiomer 852391-20-9 Necrostatin 2 S enantiomer is a potent necroptosis inhibitor with EC50 of 50 nM.
CSN18473 Necrostatin 2 852391-19-6 Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
CSN15733 Necrostatin 2 racemate 852391-15-2 Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
CSN11280 Lenalidomide   191732-72-6 Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.
CSN11280 Lenalidomide   191732-72-6 Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.
CSN17616 Lenalidomide hydrochloride 1243329-97-6 Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM.
CSN18463 Lenalidomide hemihydrate 847871-99-2 Lenalidomide is a potent inhibitor of TNF-α and has antiangiogenic effect.
CSN26222 Homoplantaginin 17680-84-1 Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.
CSN26529 GSK2245035 1207629-49-9 GSK2245035 is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity. GSK2245035 shows excellent pharmaceutical properties that allow reliable delivery of doses as low as 1 ng per actuation of an intranasal spray formulation. Intranasal GSK2245035 has an acceptable safety profile at doses that induce local TLR7-mediated immune responses.
CSN17960 GSK481 1622849-58-4 GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.
CSN14854 Grandifloroside 61186-24-1 Grandifloroside, a natural product isolated and purified from the branch of Emmenopterys henryi Oliv.
CSN16027 Forsythoside B 81525-13-5 Forsythoside B is a natural product isolated and purified from the fruits of Forsythia suspensa which inhibits inflammatory response,and has antioxidant properties with potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and can rescue cardiac function from I/R injury.
CSN17713 DCVC 13419-46-0 DCVC E-isomer inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.
CSN18895 C 87 1609281-56-2 C 87 is a small-moleculeTNFα inhibitor and potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
CSN17109 Butoconazole nitrate 64872-77-1 Butoconazole nitrate is an anti-fungal agent and the IC50s of IL-2, TNFα, IFN and GM-CSF are 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.
CSN16975 Bioymifi 1420071-30-2 Bioymifi is an activatior of the TRAIL receptor DR5 in cancer cells.
CSN19770 14-Deoxyandrographolide 4176-97-0 14-Deoxyandrographolide, a natural product isolated and purified from the herbs of Andrographis paniculata (Burm.
CSN27597 (Rac)-Benpyrine 1333714-43-4 (Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice.
CSN_mab1009 Adalimumab 331731-18-1
CSN_mab1033 Infliximab 170277-31-3
CSN27828 UTL-5g 646530-37-2
CSN41534 Hispidol 5786-54-9
CSN38382 Loganic acid 6′-O-β-D-glucoside 176226-39-4
CSN36379 Ganoderic acid C1 95311-97-0
CSN36575 Soyasapogenol A 508-01-0
CSN50026 (3E)-2,3-Dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-4H-1-benzopyran-4-one 1031206-36-6
CSN51435 AN0128 872044-70-7
CSN66808 Benpyrine 2550398-89-3
CSN68617 TNF-α-IN-2 2074702-04-6
CSN78486 TNF-α-IN-6 2699704-20-4
CSN81038 EJMC-1 397281-20-8
CSN84144 C 87 332420-90-3
CSN85337 UCB-5307 1515887-44-1
CSN86594 Anti-inflammatory agent 22 2721484-76-8
CSN90086 Sinulatumolin C 2570255-84-2
CSN104358 Isoindoline-1,3-dithione 18138-19-7
CSN103014 LASSBio-1135 852453-71-5
CSN51568 4-(3-Hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenol 537-33-7
CSN51567 Magnesium (2R,3S)-2,3,4-trihydroxybutanoate 778571-57-6
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