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TNF-alpha
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12073 | Thalidomide | 50-35-1 | Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects. |
| CSN51354 | SM-7368 | 380623-76-7 | SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. |
| CSN11309 | Roquinimex | 84088-42-6 | Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha. |
| CSN21166 | R-7050 | 303997-35-5 | R-7050 is an antagonist of tumor necrosis factor receptor (TNFR) that towards TNFα. |
| CSN12289 | QNZ | 545380-34-5 | QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively. |
| CSN13185 | Pomalidomide | 19171-19-8 | Pomalidomide can inhibit LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. |
| CSN15896 | PF-3644022 | 1276121-88-0 | PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models. |
| CSN22471 | Nedocromil Sodium | 69049-74-7 | Nedocromil Sodium is a potent TNF-α inhibitor with an IC50 value of 1.67 μM for Blood eosinophils. |
| CSN11280 | Lenalidomide | 191732-72-6 | Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM. |
| CSN11280 | Lenalidomide | 191732-72-6 | Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM. |
| CSN17616 | Lenalidomide HCl | 1243329-97-6 | Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM. |
| CSN18463 | Lenalidomide Hemihydrate | 847871-99-2 | Lenalidomide is a potent inhibitor of TNF-α and has antiangiogenic effect. |
| CSN26222 | Hispiduloside | 17680-84-1 | Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway. |
| CSN14854 | Grandifloroside | 61186-24-1 | Grandifloroside, a natural product isolated and purified from the branch of Emmenopterys henryi Oliv. |
| CSN16027 | Forsythoside B | 81525-13-5 | Forsythoside B is a natural product isolated and purified from the fruits of Forsythia suspensa which inhibits inflammatory response,and has antioxidant properties with potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and can rescue cardiac function from I/R injury. |
| CSN17713 | DCVC | 13419-46-0 | DCVC E-isomer inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro. |
| CSN17109 | Butoconazole Nitrate | 64872-77-1 | Butoconazole nitrate is an anti-fungal agent and the IC50s of IL-2, TNFα, IFN and GM-CSF are 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. |
| CSN16975 | Bioymifi | 1420071-30-2 | Bioymifi is an activatior of the TRAIL receptor DR5 in cancer cells. |
| CSN19770 | 14-Deoxyandrographolide | 4176-97-0 | 14-Deoxyandrographolide, a natural product isolated and purified from the herbs of Andrographis paniculata (Burm. |
