400-920-2911
上海市杨浦区翔殷路128号1号楼101
Topoisomerase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18018 | TAS-103 | 174634-08-3 | TAS-103 is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
| CSN17261 | TAS-103 2HCl | 174634-09-4 | TAS-103 2HCl is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
| CSN19363 | SN-38 | 86639-52-3 | SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| CSN18629 | Pirarubicin HCl | 95343-20-7 | Pirarubicin HCl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
| CSN16100 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| CSN25281 | NSC745887 | 54490-26-5 | NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. |
| CSN27362 | Nalidixic acid sodium salt | 3374-05-8 | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| CSN16183 | Moxifloxacin HCl | 186826-86-8 | Moxifloxacin HCl is a fluoroquinolone antibiotic agent. |
| CSN23384 | Levofloxacin HCl | 177325-13-2 | Levofloxacin HCl, a fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and topoisomerase IV. |
| CSN19462 | Irinotecan | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
| CSN19463 | Irinotecan HCl | 100286-90-6 | Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
| CSN17751 | INNO-206 | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| CSN19812 | Idarubicin | 58957-92-9 | Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. |
| CSN16766 | Idarubicin HCl | 57852-57-0 | Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| CSN17124 | Exatecan | 171335-80-1 | Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
| CSN16298 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM). |
| CSN16402 | Epirubicin HCl | 56390-09-1 | Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent. |
| CSN18924 | Ellipticine HCl | 5081-48-1 | Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities. |
| CSN16255 | Doxorubicin HCl | 25316-40-9 | Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| CSN16731 | Daunorubicin HCl | 23541-50-6 | Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis. |
| CSN16042 | Ciprofloxacin HCl H2O | 86393-32-0 | Ciprofloxacin HCl is an antibiotic agent and used to treat bacterial infections. |
| CSN16581 | Campathecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN20398 | Aclarubicin | 57576-44-0 | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN20399 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN20799 | 10-Hydroxycamptothecin | 64439-81-2 | (±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate. |