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Topoisomerase
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
CSN24630 | Trovafloxacin Mesylate | 147059-75-4 | Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml). |
CSN18018 | TAS-103 | 174634-08-3 | TAS-103 is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
CSN17261 | TAS-103 2HCl | 174634-09-4 | TAS-103 2HCl is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
CSN17255 | SW044248 | 522650-83-5 | SW044248 is a noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. |
CSN19363 | SN-38 | 86639-52-3 | SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
CSN20053 | Sabarubicin | 211100-13-9 | Sabarubicin is a Top II inhibitor with anticancer activity. |
CSN12328 | Pixantrone | 144510-96-3 | Pixantrone is an experimental antineoplastic drug. |
CSN18629 | Pirarubicin HCl | 95343-20-7 | Pirarubicin HCl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
CSN25281 | NSC745887 | 54490-26-5 | NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. |
CSN27362 | Nalidixic acid sodium salt | 3374-05-8 | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria. |
CSN23384 | Levofloxacin HCl | 177325-13-2 | Levofloxacin HCl, a fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and topoisomerase IV. |
CSN19462 | Irinotecan | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
CSN19463 | Irinotecan HCl | 100286-90-6 | Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
CSN21689 | Intoplicine | 125974-72-3 | Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. |
CSN17751 | INNO-206 | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
CSN19812 | Idarubicin | 58957-92-9 | Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. |
CSN17998 | Exatecan Mesylate | 169869-90-3 | Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
CSN17124 | Exatecan | 171335-80-1 | Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
CSN26783 | Etoposide phosphate disodium | 122405-33-8 | Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy[1][2]. |
CSN18924 | Ellipticine HCl | 5081-48-1 | Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities. |
CSN17904 | DOXO-EMCH | 151038-96-9 | DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug. |
CSN20016 | Coralyne | 6872-73-7 | Coralyne is a cytotoxic agent trageting topoisoerase I, used in combinational chemotherapy to improve the effectiveness in combating proliferation of cancer cells. |
CSN21384 | BNP 1350 | 203923-89-1 | BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity. |
CSN21568 | Belotecan HCl | 213819-48-8 | Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I. |
CSN26396 | BAnoxantrone (dihydrochloride) | 252979-56-9 | Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. |
CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
CSN17465 | Amrubicin HCl | 110311-30-3 | Amrubicin HCl is a topoisomerase II inhibitor used in the treatment of lung cancer. |
CSN19347 | Alternariol | 641-38-3 | Alternariol is a mycotoxin, topoisomerase I and II inhibitor and potential ER agonist found in Alternaria. |
CSN20400 | AEZS-108 | 139570-93-7 | AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). |
CSN20398 | Aclarubicin | 57576-44-0 | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
CSN20399 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
CSN25171 | 1,4-Naphthoquinone | 130-15-4 | A choleretic. |
CSN20799 | 10-Hydroxycamptothecin | 64439-81-2 | (±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate. |