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Topoisomerase

Topoisomerase

货号 产品名 CAS号 信息
CSN18021 Voreloxin 175414-77-4 Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18023 Voreloxin HCl 175519-16-1 Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18018 TAS-103 174634-08-3 TAS-103 is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).
CSN17261 TAS-103 2HCl 174634-09-4 TAS-103 2HCl is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).
CSN19363 SN-38 86639-52-3 SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
CSN20053 Sabarubicin 211100-13-9 Sabarubicin is a Top II inhibitor with anticancer activity.
CSN18629 Pirarubicin HCl 95343-20-7 Pirarubicin HCl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
CSN16100 Pefloxacin Mesylate Dihydrate 149676-40-4 Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN27362 Nalidixic acid sodium salt 3374-05-8 Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
CSN16703 Nadifloxacin 124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN16183 Moxifloxacin HCl 186826-86-8 Moxifloxacin HCl is a fluoroquinolone antibiotic agent.
CSN23384 Levofloxacin HCl 177325-13-2 Levofloxacin HCl, a fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and topoisomerase IV.
CSN19462 Irinotecan   97682-44-5 Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1.
CSN19463 Irinotecan HCl 100286-90-6 Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding.
CSN17751 INNO-206 1361644-26-9 INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
CSN19812 Idarubicin 58957-92-9 Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin.
CSN16766 Idarubicin HCl 57852-57-0 Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
CSN15938 Finafloxacin HCl 209342-41-6 Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates.
CSN17998 Exatecan Mesylate 169869-90-3 Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.
CSN17124 Exatecan 171335-80-1 Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.
CSN16298 Etoposide 33419-42-0 Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM).
CSN16402 Epirubicin HCl 56390-09-1 Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent.
CSN18924 Ellipticine HCl 5081-48-1 Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities.
CSN16255 Doxorubicin HCl   25316-40-9 Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
CSN17904 DOXO-EMCH 151038-96-9 DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug.
CSN16731 Daunorubicin HCl 23541-50-6 Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.
CSN16820 Daun02 290304-24-4 Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor, and alsois a daunorubicin b-galactoside prodrug for use in conjunction.
CSN20016 Coralyne 6872-73-7 Coralyne is a cytotoxic agent trageting topoisoerase I, used in combinational chemotherapy to improve the effectiveness in combating proliferation of cancer cells.
CSN16042 Ciprofloxacin HCl H2O 86393-32-0 Ciprofloxacin HCl is an antibiotic agent and used to treat bacterial infections.
CSN16581 Campathecin 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.
CSN18312 Amsacrine 51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN17465 Amrubicin HCl 110311-30-3 Amrubicin HCl is a topoisomerase II inhibitor used in the treatment of lung cancer.
CSN19347 Alternariol 641-38-3 Alternariol is a mycotoxin, topoisomerase I and II inhibitor and potential ER agonist found in Alternaria.
CSN20400 AEZS-108 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN20398 Aclarubicin 57576-44-0 Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN20399 Aclarubicin HCl 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN25171 1,4-Naphthoquinone 130-15-4 A choleretic.
CSN20799 10-Hydroxycamptothecin 64439-81-2 (±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate.
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