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Topoisomerase

Topoisomerase

货号 产品名 CAS号 信息
CSN26782 Zabofloxacin HCl 623574-00-5 Zabofloxacin, also known as DW-224; DW-224a; PB-101, is DNA topoisomerase IV inhibitor potentially for the treatment of chronic obstructive pulmonary disease. Zabofloxacin shows activity for multidrug-resistant infections due to Gram-positive bacteria. Zabofloxacin has a broad spectrum of antimicrobial activity, which is especially potent against Gram-positive bacteria.
CSN20008 Voacamine 3371-85-5 Voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi by inhibiting the relaxation activity of topoisomerase IB.
CSN24630 Trovafloxacin mesylate 147059-75-4 Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).
CSN19701 Top-Tdp Tri Inhibitor C12 2092927-74-5 Top-Tdp tri inhibitor C12 is one of the first triple inhibitors of human topoisomerase 1, tyrosyl–DNA phohosphodiesterase 1 (Tdp1), and tyrosyl–DNA phosphodiesterase 2 (Tdp2).
CSN19363 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 86639-52-3 SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
CSN20053 Sabarubicin 211100-13-9 Sabarubicin is a Top II inhibitor with anticancer activity.
CSN12328 6,9-Bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione 144510-96-3 Pixantrone is an experimental antineoplastic drug.
CSN32496 PEN-866 1472614-83-7 PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN19751 Nisc-6 2097636-49-0 NISC-6 is a napthalamide-isoselenocyanate compound which acts as a dual Topoisomerase-IIα and Akt pathway inhibitor.
CSN27362 Sodium 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 3374-05-8 Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
CSN23384 Levofloxacin HCl 177325-13-2 Levofloxacin HCl, a fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and topoisomerase IV.
CSN19462 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate   97682-44-5 Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1.
CSN19463 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride 100286-90-6 Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding.
CSN21689 Intoplicine 125974-72-3 Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. 
CSN22430 Indotecan 915303-09-2 Indotecan is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
CSN19812 Idarubicin 58957-92-9 Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin.
CSN20002 Gepotidacin 1075236-89-3 Gepotidacin is a first in class triazaacenaphthylene antibiotic that inhibits bacterial type II DNA replication by inhibiting the activity of bacterial topoisomerase and has in vitro activity against susceptible and drug-resistant pathogens.
CSN21909 Gemifloxacin Mesilate 210353-56-3 Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth.
CSN26783 Etoposide phosphate disodium 122405-33-8 Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy[1][2].
CSN18924 Ellipticine HCl 5081-48-1 Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities.
CSN20016 Coralyne 6872-73-7 Coralyne is a cytotoxic agent trageting topoisoerase I, used in combinational chemotherapy to improve the effectiveness in combating proliferation of cancer cells.
CSN18949 Chebulinic acid 18942-26-2 Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
CSN21384 Karenitecin 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN32410 RTA 744 293736-67-1 Berubicin hydrochloride is the hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity.
CSN21568 Belotecan hydrochloride 213819-48-8 Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I.
CSN26396 Banoxantrone 2HCl 252979-56-9 Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
CSN19347 Alternariol 641-38-3 Alternariol is a mycotoxin, topoisomerase I and II inhibitor and potential ER agonist found in Alternaria.
CSN26781 MC-DOXHZN HCl 480998-12-7 Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.
CSN20400 Zoptarelin doxorubicin 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN20398 Aclacinomycin A 57576-44-0 Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN20399 Aclacinomycin A HCl 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN25171 1,4-Naphthoquinone 130-15-4 A choleretic.
CSN15244 3-O-trans-p-Coumaroyltormentic acid 121064-78-6 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia.
CSN20799 (±)-10-Hydroxycamptothecin 64439-81-2 (±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate.
CSN24441 5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid) 4431-00-9
CSN38952 MC-SN38 1473403-87-0
CSN39971 DRF-1042 200619-13-2
CSN42220 IST-622 128201-92-3
CSN68192 Intoplicine dimesylate 133711-99-6
CSN73211 GL-331 127882-73-9
CSN80473 Epolactaene 167782-17-4
CSN87898 Belotecan 256411-32-2
CSN86599 4,4'-((2R,3S)-Butane-2,3-diyl)bis(piperazine-2,6-dione) N/A
CSN105086 ICRF-193 21416-88-6
CSN107321 Makaluvamine A 146555-78-4
CSN103969 N-(1,11-Dihydroxy-5,7-dioxo-12-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-6(7H,12H,13H)-yl)formamide 151069-12-4
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