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Topoisomerase

Topoisomerase

货号 产品名 CAS号 信息
CSN18021 Voreloxin 175414-77-4 Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18023 Voreloxin HCl 175519-16-1 Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN24630 Trovafloxacin Mesylate 147059-75-4 Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).
CSN18018 TAS-103 174634-08-3 TAS-103 is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).
CSN17261 TAS-103 2HCl 174634-09-4 TAS-103 2HCl is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).
CSN17255 SW044248 522650-83-5 SW044248 is a noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.
CSN19363 SN-38 86639-52-3 SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
CSN20053 Sabarubicin 211100-13-9 Sabarubicin is a Top II inhibitor with anticancer activity.
CSN12328 Pixantrone 144510-96-3 Pixantrone is an experimental antineoplastic drug.
CSN18629 Pirarubicin HCl 95343-20-7 Pirarubicin HCl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN27362 Nalidixic acid sodium salt 3374-05-8 Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
CSN23384 Levofloxacin HCl 177325-13-2 Levofloxacin HCl, a fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and topoisomerase IV.
CSN19462 Irinotecan   97682-44-5 Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1.
CSN19463 Irinotecan HCl 100286-90-6 Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding.
CSN21689 Intoplicine 125974-72-3 Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. 
CSN17751 INNO-206 1361644-26-9 INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
CSN19812 Idarubicin 58957-92-9 Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin.
CSN17998 Exatecan Mesylate 169869-90-3 Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.
CSN17124 Exatecan 171335-80-1 Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.
CSN26783 Etoposide phosphate disodium 122405-33-8 Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy[1][2].
CSN18924 Ellipticine HCl 5081-48-1 Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities.
CSN17904 DOXO-EMCH 151038-96-9 DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug.
CSN20016 Coralyne 6872-73-7 Coralyne is a cytotoxic agent trageting topoisoerase I, used in combinational chemotherapy to improve the effectiveness in combating proliferation of cancer cells.
CSN21384 BNP 1350 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN21568 Belotecan HCl 213819-48-8 Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I.
CSN26396 BAnoxantrone (dihydrochloride) 252979-56-9 Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
CSN18312 Amsacrine 51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN17465 Amrubicin HCl 110311-30-3 Amrubicin HCl is a topoisomerase II inhibitor used in the treatment of lung cancer.
CSN19347 Alternariol 641-38-3 Alternariol is a mycotoxin, topoisomerase I and II inhibitor and potential ER agonist found in Alternaria.
CSN20400 AEZS-108 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN20398 Aclarubicin 57576-44-0 Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN20399 Aclarubicin HCl 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN25171 1,4-Naphthoquinone 130-15-4 A choleretic.
CSN20799 10-Hydroxycamptothecin 64439-81-2 (±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate.
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