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Topoisomerase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12283 | 2,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione | 4707-32-8 | β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC50=0.44 μM). |
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN12922 | Topotecan | 123948-87-8 | Topotecan is an inhibitor of topoisomerase I and the IC50 values in cancer cells are less than 6 μM. |
| CSN12236 | (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride | 119413-54-6 | Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. |
| CSN12049 | (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN12044 | Temafloxacin | 108319-06-8 | Temafloxacin is a fluoroquinolone antibiotic drug which was withdrawn from sale in the United States shortly after its approval in 1992 because of serious adverse effects resulting in three deaths. |
| CSN18018 | TAS-103 | 174634-08-3 | TAS-103 is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
| CSN17261 | TAS-103 2HCl | 174634-09-4 | TAS-103 2HCl is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
| CSN17255 | SW044248 | 522650-83-5 | SW044248 is a noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. |
| CSN11873 | Rufloxacin | 101363-10-4 | Rufloxacin is a quinolone antibiotic. |
| CSN13079 | 9-Nitrocamptothecin | 91421-42-0 | Rubitecan is an oral topoisomerase inhibitor. |
| CSN14282 | Podocarpusflavone A | 22136-74-9 | Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus, and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. |
| CSN13759 | PNU-159682 | 202350-68-3 | PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a topoisomerase inhibitor and ADCs cytotoxin. |
| CSN12327 | 6,9-Bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione dimaleate | 144675-97-8 | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone dimaleate is an experimental antineoplastic drug. |
| CSN11733 | Pirarubicin | 72496-41-4 | Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
| CSN18629 | Pirarubicin HCl | 95343-20-7 | Pirarubicin HCl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
| CSN16100 | 1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid mesylate dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| CSN12979 | 9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | 82419-36-1 | Ofloxacin, a fluoroquinolone compound, can inhibit bacterial DNA gyrase. |
| CSN11583 | Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate | 1476-53-5 | Novobiocin sodium is an antibiotic that derived from Streptomyces niveus. |
| CSN11576 | 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid | 70458-96-7 | Norfloxacin inhibits DNA gyrase and is used as a broad-spectrum antibiotic against both Gram-positive and Gram-negative bacteria. |
| CSN11514 | 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 389-08-2 | Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| CSN16183 | Moxifloxacin HCl | 186826-86-8 | Moxifloxacin HCl is a fluoroquinolone antibiotic agent. |
| CSN11452 | 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione | 65271-80-9 | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. |
| CSN11453 | 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione dihydrochloride | 70476-82-3 | Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity. |
| CSN11362 | 9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,3,4]oxadiazino[6,5,4-ij]quinoline-6-carboxylic acid | 115550-35-1 | Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic. |
| CSN12634 | (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate | 136572-09-3 | Irinotecan HCl inhibits topoisomerase 1 and prevent DNA from unwinding. |
| CSN17751 | Aldoxorubicin | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| CSN16766 | Idarubicin HCl | 57852-57-0 | Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| CSN18319 | Genz-644282 | 529488-28-6 | Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity (IC50=1.2 nM). |
| CSN12573 | Gatifloxacin | 112811-59-3 | Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family. |
| CSN15938 | Finafloxacin hydrochloride | 209342-41-6 | Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates. |
| CSN17998 | (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione methanesulfonate | 169869-90-3 | Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
| CSN17124 | Exatecan | 171335-80-1 | Exatecan is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. |
| CSN16298 | (5R,5aR,8aR,9S)-9-(((4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM). |
| CSN16402 | Epirubicin HCl | 56390-09-1 | Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent. |
| CSN12399 | Ellipticine | 519-23-3 | Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 1.25±0.13, 0.67±0.06, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.44±0.03, 0.49±0.04, and 1.48±0.62 μM for Breast adenocarcinoma MCF-7, Leukemia HL-60, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-3, Neuroblastoma UKF-NB-4, and Glioblastoma U87MG cell, respectively. |
| CSN12607 | Doxorubicin | 23214-92-8 | Doxorubicin is a topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells. |
| CSN16255 | (8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride | 25316-40-9 | Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| CSN17904 | Doxo-emch | 151038-96-9 | DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug. |
| CSN16731 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride | 23541-50-6 | Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis. |
| CSN16820 | Daun02 | 290304-24-4 | Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor, and alsois a daunorubicin b-galactoside prodrug for use in conjunction. |
| CSN13048 | Ciprofloxacin | 85721-33-1 | Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
| CSN16042 | 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate | 86393-32-0 | Ciprofloxacin HCl is an antibiotic agent and used to treat bacterial infections. |
| CSN16581 | (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. |
| CSN12520 | Balofloxacin | 127294-70-6 | Balofloxacin, a quinolone antibiotic, can interfer with DNA gyrase and inhibit the synthesis of bacterial DNA. |
| CSN15926 | Balofloxacin dihydrate | 151060-21-8 | Balofloxacin is a fluorinated quinolone antibiotic agent and a topoisomerase ligase inhibitor. |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN17465 | (7S,9S)-9-Acetyl-9-amino-7-(((2S,4S,5R)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride | 110311-30-3 | Amrubicin HCl is a topoisomerase II inhibitor used in the treatment of lung cancer. |
