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Transferase
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN18065 | Tipifarnib S-Enantiomer | 192185-71-0 | Tipifarnib S-enantiomer is the enantiomer of tipifarnib, a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. |
CSN12963 | Tipifarnib | 192185-72-1 | Tipifarnib is an inhibitor of farnesyltransferase with IC50 of 0.6 nM. |
CSN16117 | Salirasib | 162520-00-5 | Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki of 2.6 μM and can inhibit the methylation of Ras. |
CSN22500 | RP-64477 | 135239-65-5 | RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). |
CSN20228 | PF-9366 | 72882-78-1 | PF-9366 is an allosteric inhibitor of Mat2A that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B, targeting S-adenosylmethionine biosynthesis, with IC50 of 420 nM and Kd of 170 nM, respectively. |
CSN10813 | Perillyl Alcohol | 536-59-4 | Perillyl Alcohol is a naturally occurring monocyclic terpene which can inhibit farnesyl transferase and geranylgeranyl transferase. |
CSN20781 | O6-Benzylguanine | 19916-73-5 | O6-Benzylguanine is an inactivator of O6-alkylguanine DNA alkyltransferase (AGT) and can prevent the repair of DNA damage induced by chemotherapeutics. It induces apoptosis and cell death. |
CSN25442 | Tris DBA | 51364-51-3 | N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst. |
CSN24695 | Myriocin | 35891-70-4 | Myriocin is a potent SPT (serine palmitoyltransferase) inhibitor. |
CSN11326 | Lonafarnib | 193275-84-2 | Lonafarnib is a FPTase inhibitor. It can inhibit H-ras (IC50 = 1.9 nM), K-ras-4B (IC50 = 5.2 nM) and N-ras (IC50 = 2.8 nM). |
CSN27242 | Lifibrate | 22204-91-7 | Lifibrate is an inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT), and phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT). |
CSN24041 | L-Glutamic acid γ-(p-nitroanilide) | 7300-59-6 | L-Glutamic acid γ-(p-nitroanilide) is a substrate for γ-glutamyl transpeptidase. |
CSN23739 | L-Glutamic acid γ-(p-nitroanilide) HCl | 67953-08-6 | L-Glutamic acid γ-(p-nitroanilide) HCl is a substrate for GGT (gamma-glutamyltransferase), which is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor. |
CSN12834 | L-778123 HCl | 253863-00-2 | L-778123 HCl is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. |
CSN27575 | Isoastilbin | 54081-48-0 | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research. |
CSN25448 | LY 78335 HCl | 39959-66-5 | High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model. |
CSN27598 | GOT1 inhibitor 2c | 732973-87-4 | GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM. |
CSN19197 | GGTI298 Trifluoroacetate | 1217457-86-7 | GGTI298 trifluoroacetate is geranylgeranyltransferase I inhibitor. It shows supression of the G1 phase of the cell cycle and induction of apoptosis. |
CSN23732 | GGTI-2418 | 501010-06-6 | GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1]. |
CSN11092 | Geraniol | 106-24-1 | Geraniol is an inhibitor of glutathion S transferase with anticarcinogenic property. |
CSN27300 | GDP-Mannose disodium salt | 148296-46-2 | GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) . |
CSN20234 | FTI-277 Trifluoroacetate | 1217447-06-7 | FTI-277 trifluoroacetate is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
CSN18001 | FTI-277 | 170006-73-2 | FTI-277 is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
CSN18044 | FTI-277 HCl | 180977-34-8 | FTI-277 HCl is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
CSN25323 | FTI-2148 | 251577-09-0 | FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM for FT-1 and GGT-1, respectively. |
CSN22389 | E-5324 | 141799-76-0 | E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM. |
CSN21070 | CP-609754 | 1190094-64-4 | CP-609754, also known as CP-609,754, LNK 754 and OSI 754, is a selective inhibitor of arnesyltransferase with potential anticancer activity. |
CSN24943 | Benzoyleneurea | 86-96-4 | Benzoyleneurea scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. |
CSN24135 | ATR-101 | 133825-80-6 | ATR-101 is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
CSN20465 | ATR-101 HCl | 133825-81-7 | ATR-101 HCl is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
CSN23571 | Aminooxyacetic acid hemihydrochloride | 2921-14-4 | Aminooxyacetic acid hemihydrochloride is an inhibitor of malate-aspartate shuttle (MAS) and also exhibits suppression of GABA-T. |
CSN10276 | Amentoflavone | 1617-53-4 | Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM. |
CSN23722 | MAT2A Inhibitor 1 | 13299-99-5 | AG-270 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with potential antineoplastic activity. |
CSN12803 | (R)-(+)-Etomoxir Sodium | 828934-41-4 | (R)-(+)-etomoxir sodium salt is inhibitor of carnitine palmitoyltransferase I (CPT1) and can reduce β-oxidation in mitochondria. It shows inhibition of cardiolipin biosynthesis. |