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Transferase

Transferase

货号 产品名 CAS号 信息
CSN22044 ZSET-845 324077-62-5 ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat.
CSN18065 Tipifarnib (S enantiomer) 192185-71-0 Tipifarnib S-enantiomer is the enantiomer of tipifarnib, a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM.
CSN22505 SHIN1 2146095-85-2 SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
CSN22500 RP-64477 135239-65-5 RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).
CSN20228 PF-9366 72882-78-1 PF-9366 is an allosteric inhibitor of Mat2A that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B, targeting S-adenosylmethionine biosynthesis, with IC50 of 420 nM and Kd of 170 nM, respectively.
CSN21788 Perhexiline maleate 6724-53-4 Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug.
CSN20781 6-(Benzyloxy)-7H-purin-2-amine 19916-73-5 O6-Benzylguanine is an inactivator of O6-alkylguanine DNA alkyltransferase (AGT) and can prevent the repair of DNA damage induced by chemotherapeutics. It induces apoptosis and cell death. 
CSN25442 Tris(dibenzylideneacetone)dipalladium(0) 51364-51-3 N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst.
CSN24695 Myriocin 35891-70-4 Myriocin is a potent SPT (serine palmitoyltransferase) inhibitor.
CSN22897 McN3716 69207-52-9 McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.
CSN22460 MAT2A inhibitor 1 2201057-10-3 MAT2A inhibitor is a methionine adenosyltransferase 2A (MATA2) inhibitor.
CSN20562 Manumycin A 52665-74-4 Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment.
CSN51116 (S)-4-(2-(4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 193275-85-3 Lonafarnib is a FPTase inhibitor. It can inhibit H-ras (IC50 = 1.9 nM), K-ras-4B (IC50 = 5.2 nM) and N-ras (IC50 = 2.8 nM).
CSN27242 Lifibrate 22204-91-7 Lifibrate is an inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT), and phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT).
CSN24041 L-γ-Glutamyl-p-nitroanilide 7300-59-6 L-Glutamic acid γ-(p-nitroanilide) is a substrate for γ-glutamyl transpeptidase.
CSN23739 GPNA HCl 67953-08-6 L-Glutamic acid γ-(p-nitroanilide) HCl is a substrate for GGT (gamma-glutamyltransferase), which is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor.
CSN27700 K-604 2HCl 217094-32-1 K-604 is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor. K-604 inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC50 = 450 nM vs. 102.85 μ M against human ACAT1 and ACAT2, respectively) and acyl-CoA-competitive (Ki = 378 nM against oleoyl-coA) manner.
CSN27575 Isoastilbin   54081-48-0 Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research.
CSN19824 Ibiglustat 1401090-53-6 Ibiglustat is a potent and selective glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor.
CSN25448 1-(2,3-Dichlorophenyl)ethanamine hydrochloride 39959-66-5 High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.
CSN27598 GOT1 inhibitor-1   732973-87-4 GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM.
CSN19197 GGTI298 Trifluoroacetate 1217457-86-7 GGTI298 trifluoroacetate is geranylgeranyltransferase I inhibitor. It shows supression of the G1 phase of the cell cycle and induction of apoptosis.
CSN23732 GGTI-2418 501010-06-6 GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1].
CSN26251 GGsTop 926281-37-0 GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT.
CSN27300 GDP-α-D-mannose disodium 148296-46-2 GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
CSN20234 FTI-277 Trifluoroacetate 1217447-06-7 FTI-277 trifluoroacetate is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
CSN22128 FTI 276 170006-72-1 FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human.
CSN25323 FTI-2148 251577-09-0 FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM for FT-1 and GGT-1, respectively.
CSN26787 FIDAS-3 1266684-01-8 for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].
CSN26788 FIDAS-5 1391934-98-7 FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1].
CSN22389 E-5324 141799-76-0 E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM.
CSN21070 CP-609754 1190094-64-4 CP-609754, also known as CP-609,754, LNK 754 and OSI 754, is a selective inhibitor of arnesyltransferase with potential anticancer activity.
CSN21915 BMS-214662 195987-41-8 BMS-214662 is a potent and selective farnesyl transferase inhibitor with potent antitumor activity with an IC50 of 1.35 nM.
CSN24943 Benzoyleneurea 86-96-4 Benzoyleneurea scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors.
CSN24135 1-(2,6-Diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea 133825-80-6 ATR-101 is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC).
CSN20465 Nevanimibe HCl 133825-81-7 ATR-101 HCl is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC).
CSN20288 Antimalarial C86(+) N/A Antimalarial C86(+) is an antimalarial inhibitor targeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy.
CSN23571 O-(Carboxymethyl)hydroxylamine hemihydrochloride 2921-14-4 Aminooxyacetic acid hemihydrochloride is an inhibitor of malate-aspartate shuttle (MAS) and also exhibits suppression of GABA-T.
CSN10276 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one 1617-53-4 Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM.
CSN22343 2,3-Diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 2201066-35-3 AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo.
CSN22342 AGI-24512 2201066-53-5 AGI-24512 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-24512 blocks growth of MTAP-deleted cancer cells in vitro.
CSN23722 MAT2A inhibitor 2 13299-99-5 AG-270 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with potential antineoplastic activity.
CSN50390 AG-270 2201056-66-6 AG-270 is a first-in-Class Oral MAT2A Inhibitor.
CSN26789 ABT-100 450839-40-4 ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).
CSN24766 FGTI-2734 1247018-19-4
CSN155999 Tris(dibenzylideneacetone)dipalladium(0) 51364-51-3
CSC155999 Tris(dibenzylideneacetone)dipalladium(0) 51364-51-3
CSC25442 Tris DBA 51364-51-3
CSN27693 iGOT1-01 882256-55-5
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