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Transferase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22044 | ZSET-845 | 324077-62-5 | ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat. |
| CSN18065 | Tipifarnib (S enantiomer) | 192185-71-0 | Tipifarnib S-enantiomer is the enantiomer of tipifarnib, a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. |
| CSN22505 | SHIN1 | 2146095-85-2 | SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. |
| CSN22500 | RP-64477 | 135239-65-5 | RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). |
| CSN20228 | PF-9366 | 72882-78-1 | PF-9366 is an allosteric inhibitor of Mat2A that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B, targeting S-adenosylmethionine biosynthesis, with IC50 of 420 nM and Kd of 170 nM, respectively. |
| CSN21788 | Perhexiline maleate | 6724-53-4 | Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug. |
| CSN20781 | 6-(Benzyloxy)-7H-purin-2-amine | 19916-73-5 | O6-Benzylguanine is an inactivator of O6-alkylguanine DNA alkyltransferase (AGT) and can prevent the repair of DNA damage induced by chemotherapeutics. It induces apoptosis and cell death. |
| CSN25442 | Tris(dibenzylideneacetone)dipalladium(0) | 51364-51-3 | N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst. |
| CSN24695 | Myriocin | 35891-70-4 | Myriocin is a potent SPT (serine palmitoyltransferase) inhibitor. |
| CSN22897 | McN3716 | 69207-52-9 | McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor. |
| CSN22460 | MAT2A inhibitor 1 | 2201057-10-3 | MAT2A inhibitor is a methionine adenosyltransferase 2A (MATA2) inhibitor. |
| CSN20562 | Manumycin A | 52665-74-4 | Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. |
| CSN51116 | (S)-4-(2-(4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide | 193275-85-3 | Lonafarnib is a FPTase inhibitor. It can inhibit H-ras (IC50 = 1.9 nM), K-ras-4B (IC50 = 5.2 nM) and N-ras (IC50 = 2.8 nM). |
| CSN27242 | Lifibrate | 22204-91-7 | Lifibrate is an inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT), and phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT). |
| CSN24041 | L-γ-Glutamyl-p-nitroanilide | 7300-59-6 | L-Glutamic acid γ-(p-nitroanilide) is a substrate for γ-glutamyl transpeptidase. |
| CSN23739 | GPNA HCl | 67953-08-6 | L-Glutamic acid γ-(p-nitroanilide) HCl is a substrate for GGT (gamma-glutamyltransferase), which is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor. |
| CSN27700 | K-604 2HCl | 217094-32-1 | K-604 is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor. K-604 inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC50 = 450 nM vs. 102.85 μ M against human ACAT1 and ACAT2, respectively) and acyl-CoA-competitive (Ki = 378 nM against oleoyl-coA) manner. |
| CSN27575 | Isoastilbin | 54081-48-0 | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research. |
| CSN19824 | Ibiglustat | 1401090-53-6 | Ibiglustat is a potent and selective glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
| CSN25448 | 1-(2,3-Dichlorophenyl)ethanamine hydrochloride | 39959-66-5 | High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model. |
| CSN27598 | GOT1 inhibitor-1 | 732973-87-4 | GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM. |
| CSN19197 | GGTI298 Trifluoroacetate | 1217457-86-7 | GGTI298 trifluoroacetate is geranylgeranyltransferase I inhibitor. It shows supression of the G1 phase of the cell cycle and induction of apoptosis. |
| CSN23732 | GGTI-2418 | 501010-06-6 | GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1]. |
| CSN26251 | GGsTop | 926281-37-0 | GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT. |
| CSN27300 | GDP-α-D-mannose disodium | 148296-46-2 | GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) . |
| CSN20234 | FTI-277 Trifluoroacetate | 1217447-06-7 | FTI-277 trifluoroacetate is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
| CSN22128 | FTI 276 | 170006-72-1 | FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human. |
| CSN25323 | FTI-2148 | 251577-09-0 | FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM for FT-1 and GGT-1, respectively. |
| CSN26787 | FIDAS-3 | 1266684-01-8 | for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2]. |
| CSN26788 | FIDAS-5 | 1391934-98-7 | FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1]. |
| CSN22389 | E-5324 | 141799-76-0 | E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM. |
| CSN21070 | CP-609754 | 1190094-64-4 | CP-609754, also known as CP-609,754, LNK 754 and OSI 754, is a selective inhibitor of arnesyltransferase with potential anticancer activity. |
| CSN21915 | BMS-214662 | 195987-41-8 | BMS-214662 is a potent and selective farnesyl transferase inhibitor with potent antitumor activity with an IC50 of 1.35 nM. |
| CSN24943 | Benzoyleneurea | 86-96-4 | Benzoyleneurea scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. |
| CSN24135 | 1-(2,6-Diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea | 133825-80-6 | ATR-101 is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
| CSN20465 | Nevanimibe HCl | 133825-81-7 | ATR-101 HCl is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
| CSN20288 | Antimalarial C86(+) | N/A | Antimalarial C86(+) is an antimalarial inhibitor targeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy. |
| CSN23571 | O-(Carboxymethyl)hydroxylamine hemihydrochloride | 2921-14-4 | Aminooxyacetic acid hemihydrochloride is an inhibitor of malate-aspartate shuttle (MAS) and also exhibits suppression of GABA-T. |
| CSN10276 | 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 1617-53-4 | Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM. |
| CSN22343 | 2,3-Diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | 2201066-35-3 | AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. |
| CSN22342 | AGI-24512 | 2201066-53-5 | AGI-24512 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-24512 blocks growth of MTAP-deleted cancer cells in vitro. |
| CSN23722 | MAT2A inhibitor 2 | 13299-99-5 | AG-270 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with potential antineoplastic activity. |
| CSN50390 | AG-270 | 2201056-66-6 | AG-270 is a first-in-Class Oral MAT2A Inhibitor. |
| CSN26789 | ABT-100 | 450839-40-4 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally). |
| CSN25766 | 3-Methyl-GABA | 1216629-00-3 | 3-Methyl-GABA is an activator of GABA aminotransferase with anticonvulsant activity. |
| CSN24766 | FGTI-2734 | 1247018-19-4 | |
| CSN155999 | Tris(dibenzylideneacetone)dipalladium(0) | 51364-51-3 | |
| CSC155999 | Tris(dibenzylideneacetone)dipalladium(0) | 51364-51-3 | |
| CSC25442 | Tris DBA | 51364-51-3 | |
| CSN27693 | iGOT1-01 | 882256-55-5 |
