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Trk Receptor

Trk Receptor

货号 产品名 CAS号 信息
CSN20508 TrkA Inhibitor C6t 1377503-70-2 TrkA inhibitor C6t is a potent and selective TrkA inhibitor (IC50=1.67 nM) showing activity in cellular proliferation and apoptosis assays and exhibiting antiangiogenic activity.
CSN20509 Trk Inhibitor C11 1614229-04-7 Trk inhibitor C11 is an orally active pan-Trk inhibitor showing efficacy in both inflammatory and neropathic pain models.
CSN20579 (7S,13R)-11-Fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one 1802220-02-5 TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
CSN27197 3-(4-((R)-2-Aminopropoxy)phenyl)-N-((R)-1-(3-fluorophenyl)ethyl)imidazo[1,2-b]pyridazin-6-amine adipate 1505515-69-4 Taletrectinib is a new-generation selective ROS1/Trk Receptor inhibitor with IC50 values of 0.207nM, 0.622nM, 2.28nM and 0.98nM for ROS1, Trk Receptor A, B and C, respectively. It induces dramatic growth inhibition of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro and in vivo.
CSN23684 Selitrectinib 2097002-61-2 LOXO-195 is a TRK kinase inhibitor (TKI) with IC50 values of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.
CSN16968 (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 1223403-58-4 LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members.
CSN22901 LM22B-10 342777-54-2 LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor. It can improve survival and increase neurite outgrowth in vitro.
CSN15969 LM22A-4 37988-18-4 LM22A-4 is a specific agonist oftyrosine kinase receptor B.
CSN13940 GW 441756 504433-23-2 GW 441756 is an inhibitor of tropomyosin-related kinase A (TrkA) with IC50 of 2 nM.
CSN15870 GNF-5837 1033769-28-6 GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively).
CSN20507 GNF-8625 1196546-33-4 GNE-8525 is a potent and selective pan-TRK inhibitor, demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats.
CSN12423 Danusertib 827318-97-8 Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It is modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc.
CSN22174 CE-245677 717899-97-3 CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
CSN22125 AZ-23 915720-21-7 AZ-23 is a potent, orally bioavailable Trk kinase inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
CSN15752 ANA-12 219766-25-3 ANA-12 is antagonist of TrkB with Kd of 10 nM.
CSN10171 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one 38183-03-8 7,8-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect.
CSN52450 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate 1223405-08-0
CSN40201 N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)acetamide 1210-83-9
CSN38326 TrkA-IN-1 1680179-43-4
CSN34279 PF-6683324 1799788-94-5
CSN34108 Tavilermide 263251-78-1
CSN34293 PF-06737007 1863905-38-7
CSN51415 CG428 2412055-93-5
CSN67217 Anizatrectinib 1824664-89-2
CSN76103 (R)-Larotrectinib 1223404-68-9
CSN85443 (3S,4R)-PF-6683324 1799789-00-6
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