货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN25461 | WS 3 | 39711-79-0 | WS 3 is an agonist of TRPM8 with an EC50 of 3.7 μM. |
CSN19515 | Vanillyl Alcohol | 498-00-0 | Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl.. |
CSN27198 | TRPM8 antagonist 14 | 259674-19-6 | TRPM8 antagonist 14 is a tryptophan-derived selective TRPM8 antagonist with IC50 value of 0.2nM. It showed significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models. |
CSN16412 | SN 2 | 823218-99-1 | SN 2 is a potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM. |
CSN25460 | 9-Phenanthrol | 484-17-3 | Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. |
CSN19507 | SB-366791 | 472981-92-3 | SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM. |
CSN18624 | RN-1734 | 946387-07-1 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). |
CSN21376 | AM-0902 | 1883711-97-4 | Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable. |
CSN19028 | Podocarpic Acid | 5947-49-9 | Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator. |
CSN17365 | Optovin | 348575-88-2 | Optovin is a reversible and photoactive activator of TRPA1 with EC50 of 2 μM in wild-type zebrafish. |
CSN25722 | OLDA | 105955-11-1 | OLDA is an agonist of endogenous vanilloid TRPV1 (VR1) receptor with EC50 of 36 nM and low affinity for rCB1 receptors (Ki = 1.6 μM). |
CSN16213 | Nonivamide | 2444-46-4 | Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L.. |
CSN15766 | ML204 | 5465-86-1 | ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 0.96 μM and 2.6 μM in fluorescent and electrophysiological assays respectively. |
CSN19023 | ML204 HCl | 2070015-10-8 | ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM. |
CSN26181 | Linoleylethanolamide | 68171-52-8 | Linoleylethanolamide is an endocannabinoid agent. It acts by binding to TRPV1, increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner. |
CSN18446 | JNJ-17203212 | 821768-06-3 | JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
CSN16140 | Icilin | 36945-98-9 | Icilin is an agonist of TRPM8 ion channel with EC50 of 0.36 μM in HEK 293 cells. |
CSN18524 | HC-067047 | 883031-03-6 | HC-067047 is a TRPV4 antagonist with IC50 value of 48 ± 6 nM in human. |
CSN16823 | HC-030031 | 349085-38-7 | HC-030031 is a blocker of TRPA1 channel that exhibits antagonistic effect on AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
CSN19708 | GSK2193874 | 1336960-13-4 | GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM. |
CSN18613 | GSK1016790A | 942206-85-1 | GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells. |
CSN25311 | GFB-8438 | 2304549-73-1 | GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. |
CSN25462 | EIPA | 1154-25-2 | EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
CSN25671 | Eact | 461000-66-8 | Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). |
CSN18220 | Chembridge-5861528 | 332117-28-9 | Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). |
CSN24060 | β-Eudesmol | 473-15-4 | Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1]. |
CSN16141 | BCTC | 393514-24-4 | BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
CSN25672 | Arvanil | 128007-31-8 | Arvanil is an antagonist of cannabinoid CB1 and vanilloid TRPV1 (VR1) with Ki values are 0.5 and 0.3 μM respectively. |
CSN24195 | AC1903 | 831234-13-0 | AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5) with IC50 of 14.7 µM. |
CSN23287 | 2-Aminoethyl diphenylborinate | 524-95-8 | 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2. |