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TRP Channel

货号 产品名 CAS号 信息
CSN17046 Zucapsaicin 25775-90-0 Zucapsaicin is a synthetic cis isomer of natural capsaicin that has therapeutic efficacy in pain accompanying osteoarthritis of the knee.
CSN22050 WS-12 68489-09-8 WS-12 is an agonist of TRPM8 with an EC50 of 39 nM.
CSN25461 WS 3 39711-79-0 WS 3 is an agonist of TRPM8 with an EC50 of 3.7 μM.
CSN19515 Vanillyl Alcohol 498-00-0 Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl..
CSN27198 TRPM8 antagonist 14 259674-19-6 TRPM8 antagonist 14 is a tryptophan-derived selective TRPM8 antagonist with IC50 value of 0.2nM. It showed significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models.
CSN25460 9-Phenanthrol 484-17-3 Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
CSN19507 SB-366791 472981-92-3 SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM.
CSN26289 RN-1747 1024448-59-6 RN-1747 is a selective agonist of transient receptor potential cation channel subfamily V member 4 (TRPV4) with EC50 value of 0.77 μM. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM.
CSN18624 RN-1734 946387-07-1 RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).
CSN18152 Pyr6 245747-08-4 Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 μM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
CSN21376 AM-0902 1883711-97-4 Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.
CSN19028 Podocarpic Acid 5947-49-9 Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator.
CSN20615 PF-05105679 1398583-31-7 PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels.
CSN19023 ML204 HCl 2070015-10-8 ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM.
CSN33231 ML-SA1 332382-54-4 ML-SA1 is an activator of TRPML1-3. It induces TRPML-mediated Ca2+ release from lysosomes.
CSN26307 JT010 917562-33-5 JT010 is an agonist of TRPA1 with EC50 of 0.65 nM.
CSN18446 JNJ-17203212 821768-06-3 JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
CSN19708 GSK2193874 1336960-13-4 GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM.
CSN18613 GSK1016790A 942206-85-1 GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
CSN25462 EIPA 1154-25-2 EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CSN24060 β-Eudesmol 473-15-4 Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1].
CSN20581 ASP 7663 1190217-35-6 ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo.
CSN25672 Arvanil 128007-31-8 Arvanil is an antagonist of cannabinoid CB1 and vanilloid TRPV1 (VR1) with Ki values are 0.5 and 0.3 μM respectively.
CSN23287 2-Aminoethyl diphenylborinate 524-95-8 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2.
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