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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17046 | Zucapsaicin | 25775-90-0 | Zucapsaicin is a synthetic cis isomer of natural capsaicin that has therapeutic efficacy in pain accompanying osteoarthritis of the knee. |
| CSN22050 | WS-12 | 68489-09-8 | WS-12 is an agonist of TRPM8 with an EC50 of 39 nM. |
| CSN25461 | WS 3 | 39711-79-0 | WS 3 is an agonist of TRPM8 with an EC50 of 3.7 μM. |
| CSN19515 | Vanillyl Alcohol | 498-00-0 | Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl.. |
| CSN27198 | TRPM8 antagonist 14 | 259674-19-6 | TRPM8 antagonist 14 is a tryptophan-derived selective TRPM8 antagonist with IC50 value of 0.2nM. It showed significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models. |
| CSN25460 | 9-Phenanthrol | 484-17-3 | Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. |
| CSN19507 | SB-366791 | 472981-92-3 | SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM. |
| CSN26289 | RN-1747 | 1024448-59-6 | RN-1747 is a selective agonist of transient receptor potential cation channel subfamily V member 4 (TRPV4) with EC50 value of 0.77 μM. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM. |
| CSN18624 | RN-1734 | 946387-07-1 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). |
| CSN18152 | Pyr6 | 245747-08-4 | Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 μM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). |
| CSN21376 | AM-0902 | 1883711-97-4 | Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable. |
| CSN19028 | Podocarpic Acid | 5947-49-9 | Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator. |
| CSN20615 | PF-05105679 | 1398583-31-7 | PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels. |
| CSN20460 | ML329 | 19992-50-8 | ML329 is a small molecule inhibitor of MITF which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM. |
| CSN19023 | ML204 HCl | 2070015-10-8 | ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM. |
| CSN33231 | ML-SA1 | 332382-54-4 | ML-SA1 is an activator of TRPML1-3. It induces TRPML-mediated Ca2+ release from lysosomes. |
| CSN26307 | JT010 | 917562-33-5 | JT010 is an agonist of TRPA1 with EC50 of 0.65 nM. |
| CSN18446 | JNJ-17203212 | 821768-06-3 | JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
| CSN19708 | GSK2193874 | 1336960-13-4 | GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM. |
| CSN18613 | GSK1016790A | 942206-85-1 | GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells. |
| CSN25462 | EIPA | 1154-25-2 | EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
| CSN24060 | β-Eudesmol | 473-15-4 | Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1]. |
| CSN20581 | ASP 7663 | 1190217-35-6 | ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo. |
| CSN23287 | 2-Aminoethyl diphenylborinate | 524-95-8 | 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2. |
