| CSN25461 |
WS 3
|
39711-79-0 |
WS 3 is an agonist of TRPM8 with an EC50 of 3.7 μM. |
| CSN19515 |
Vanillyl Alcohol
|
498-00-0 |
Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl.. |
| CSN27198 |
TRPM8 antagonist 14
|
259674-19-6 |
TRPM8 antagonist 14 is a tryptophan-derived selective TRPM8 antagonist with IC50 value of 0.2nM. It showed significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models. |
| CSN16412 |
SN 2
|
823218-99-1 |
SN 2 is a potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM. |
| CSN25460 |
9-Phenanthrol
|
484-17-3 |
Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. |
| CSN19507 |
SB-366791
|
472981-92-3 |
SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM. |
| CSN18624 |
RN-1734
|
946387-07-1 |
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). |
| CSN21376 |
AM-0902
|
1883711-97-4 |
Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable. |
| CSN19028 |
Podocarpic Acid
|
5947-49-9 |
Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator. |
| CSN17365 |
Optovin
|
348575-88-2 |
Optovin is a reversible and photoactive activator of TRPA1 with EC50 of 2 μM in wild-type zebrafish. |
| CSN25722 |
OLDA
|
105955-11-1 |
OLDA is an agonist of endogenous vanilloid TRPV1 (VR1) receptor with EC50 of 36 nM and low affinity for rCB1 receptors (Ki = 1.6 μM). |
| CSN16213 |
Nonivamide
|
2444-46-4 |
Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L.. |
| CSN15766 |
ML204
|
5465-86-1 |
ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 0.96 μM and 2.6 μM in fluorescent and electrophysiological assays respectively. |
| CSN19023 |
ML204 HCl
|
2070015-10-8 |
ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM. |
| CSN26181 |
Linoleylethanolamide
|
68171-52-8 |
Linoleylethanolamide is an endocannabinoid agent. It acts by binding to TRPV1, increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner. |
| CSN18446 |
JNJ-17203212
|
821768-06-3 |
JNJ-17203212 is a selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
| CSN16140 |
Icilin
|
36945-98-9 |
Icilin is an agonist of TRPM8 ion channel with EC50 of 0.36 μM in HEK 293 cells. |
| CSN18524 |
HC-067047
|
883031-03-6 |
HC-067047 is a TRPV4 antagonist with IC50 value of 48 ± 6 nM in human. |
| CSN16823 |
HC-030031
|
349085-38-7 |
HC-030031 is a blocker of TRPA1 channel that exhibits antagonistic effect on AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
| CSN19708 |
GSK2193874
|
1336960-13-4 |
GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM. |
| CSN18613 |
GSK1016790A
|
942206-85-1 |
GSK1016790A is a potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells. |
| CSN25311 |
GFB-8438
|
2304549-73-1 |
GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. |
| CSN25462 |
EIPA
|
1154-25-2 |
EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
| CSN25671 |
Eact
|
461000-66-8 |
Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). |
| CSN18220 |
Chembridge-5861528
|
332117-28-9 |
Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). |
| CSN24060 |
β-Eudesmol
|
473-15-4 |
Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1]. |
| CSN16141 |
BCTC
|
393514-24-4 |
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
| CSN25672 |
Arvanil
|
128007-31-8 |
Arvanil is an antagonist of cannabinoid CB1 and vanilloid TRPV1 (VR1) with Ki values are 0.5 and 0.3 μM respectively. |
| CSN24195 |
AC1903
|
831234-13-0 |
AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5) with IC50 of 14.7 µM. |
| CSN23287 |
2-Aminoethyl diphenylborinate
|
524-95-8 |
2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2. |
400-920-2911
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