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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17046 | (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide | 25775-90-0 | Zucapsaicin is a synthetic cis isomer of natural capsaicin that has therapeutic efficacy in pain accompanying osteoarthritis of the knee. |
| CSN22050 | AVX-012 | 68489-09-8 | WS-12 is an agonist of TRPM8 with an EC50 of 39 nM. |
| CSN25461 | TRPM8 agonist WS-3 | 39711-79-0 | WS 3 is an agonist of TRPM8 with an EC50 of 3.7 μM. |
| CSN19515 | Vanillyl alcohol | 498-00-0 | Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl.. |
| CSN26451 | 8-Fluoro-3-(4-(4-fluorophenoxy)phenyl)-2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one hydrochloride | 2314467-60-0 | TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1]. |
| CSN27198 | TRPM8 antagonist 2 | 259674-19-6 | TRPM8 antagonist 14 is a tryptophan-derived selective TRPM8 antagonist with IC50 value of 0.2nM. It showed significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models. |
| CSN25460 | 9-Phenanthrol | 484-17-3 | Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. |
| CSN19507 | SB-366791 | 472981-92-3 | SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM. |
| CSN18783 | SAR7334 | 1333210-07-3 | SAR7334 is a potent TRPC6 (Transient receptor potential cation channel, subfamily C, member 6) inhibitor. |
| CSN26289 | RN-1747 | 1024448-59-6 | RN-1747 is a selective agonist of transient receptor potential cation channel subfamily V member 4 (TRPV4) with EC50 value of 0.77 μM. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM. |
| CSN29464 | A-425619 | 581809-67-8 | Potent TRPV1 antagonist. |
| CSN21376 | AM-0902 | 1883711-97-4 | Potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable. |
| CSN19028 | Podocarpic acid | 5947-49-9 | Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator. |
| CSN20615 | PF-05105679 | 1398583-31-7 | PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels. |
| CSN32915 | Asivatrep | 1005168-10-4 | PAC 14028 is a vanilloid VR1 receptor (TRPV1) antagonist. |
| CSN25722 | N-Oleoyl Dopamine | 105955-11-1 | OLDA is an agonist of endogenous vanilloid TRPV1 (VR1) receptor with EC50 of 36 nM and low affinity for rCB1 receptors (Ki = 1.6 μM). |
| CSN20361 | MRS 1477 | 212200-21-0 | MRS1477 is a positive allosteric modulator of TRPV1 channels targeting breast cancer cells. |
| CSN20460 | ML329 | 19992-50-8 | ML329 is a small molecule inhibitor of MITF which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM. |
| CSN19023 | ML204 HCl | 2070015-10-8 | ML204 HCl is a potent, selective TRPC4 channel inhibitor with IC50 of 0.96 μM. |
| CSN33231 | ML-SA1 | 332382-54-4 | ML-SA1 is an activator of TRPML1-3. It induces TRPML-mediated Ca2+ release from lysosomes. |
| CSN26127 | MDR-652 | 1933528-96-1 | MDR-652 is a high-affinity TRPV1 agonist with Ki value of 11.4nM. |
| CSN22440 | JYL 1421 | 401907-26-4 | JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM. |
| CSN26307 | JT010 | 917562-33-5 | JT010 is an agonist of TRPA1 with EC50 of 0.65 nM. |
| CSN34303 | GsMTx4 | 1209500-46-8 | GsMTx4 is a spider venom peptide. It selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. |
| CSN19708 | GSK2193874 | 1336960-13-4 | GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM. |
| CSN26273 | GSK1702934A | 924377-85-5 | GSK1702934A is an agonist of TRPC3 that modulates cardiac contractility and arrhythmogenesis by activating TRPC3. |
| CSN25311 | GFB-8438 | 2304549-73-1 | GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. |
| CSN33181 | Elismetrep | 1400699-64-0 | Elismetrep is a Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8) antagonist. |
| CSN25462 | EIPA | 1154-25-2 | EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
| CSN25671 | Eact | 461000-66-8 | Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). |
| CSN19025 | D-3263 HCl | 1008763-54-9 | D-3263 HCl is an orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist. |
| CSN24060 | Beta-Eudesmol | 473-15-4 | Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1[1]. |
| CSN20581 | ASP7663 | 1190217-35-6 | ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo. |
| CSN25672 | Arvanil | 128007-31-8 | Arvanil is an antagonist of cannabinoid CB1 and vanilloid TRPV1 (VR1) with Ki values are 0.5 and 0.3 μM respectively. |
| CSN21956 | AMG9810 | 545395-94-6 | AMG9810 is an antagonist of TRPV1 receptor with IC50 of 17 nM and exhibits antihyperalgesic properties in rat model. |
| CSN24182 | AMG 333 | 1416799-28-4 | AMG 333 is a potent and selective TRPM8 antagonist with IC50 value of 13nM. |
| CSN24195 | AC1903 | 831234-13-0 | AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5) with IC50 of 14.7 µM. |
| CSN19859 | A-967079 | 1170613-55-4 | A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). |
| CSN23287 | 2-Aminoethyl diphenylborinate | 524-95-8 | 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2. |
| CSN32430 | Piromelatine | 946846-83-9 | |
| CSN41903 | Benzamil | 2898-76-2 | |
| CSN38767 | Englerin A | 1094250-15-3 | |
| CSN43385 | Pico145 | 1628287-16-0 | |
| CSN43384 | HC-070 | 1628291-95-1 | |
| CSN67117 | ML-SI3 | 891016-02-7 | |
| CSN79570 | (1R,2R)-ML-SI3 | 2418594-00-8 | |
| CSN81205 | N-Arachidonoylserotonin | 187947-37-1 |
