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Wnt
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN26794 | β-catenin/CBP-IN-1 | 1198780-38-9 | β-catenin/CBP-IN-1 is a potent and selective CBP/β-catenin antagonist, extracted from the patent WO2014092154A1. β-catenin/CBP-IN-1 has the potential for the study of liver fibrosis induced by hepatitis virus[1]. |
| CSN13998 | Xanthatin | 26791-73-1 | Xanthatin, a natural product isolated and purified from the fruits of Xanthium sibiricum with cytotoxic, antibacterial and antifungal activities, can inhibit murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. |
| CSN11885 | Salinomycin | 53003-10-4 | Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling. |
| CSN19163 | PNU-74654 | 113906-27-7 | PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. |
| CSN11650 | Pamidronic acid | 40391-99-9 | Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis. |
| CSN23011 | NSC668036 | 144678-63-7 | NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. |
| CSN27659 | MSAB | 173436-66-3 | MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. |
| CSN23594 | Methyl vanillate | 3943-74-6 | Methyl vanillate has ability to increase bone mass and activate wnt/β-catenin pathway. It can act as a potential lead anabolic agent for anti-osteoporosis drugs. |
| CSN22542 | LF3 | 664969-54-4 | LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 μM. It can disrupt the interaction between β-catenin and TCF4. |
| CSN19247 | KYA1797K | 1956356-56-1 | KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). |
| CSN16086 | KY02111 | 1118807-13-8 | KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes. |
| CSN22870 | JW67 | 442644-28-2 | JW 67 is an inhibitor of canonical Wnt pathway signaling with IC50 of 1.17 μM. |
| CSN13654 | IWR-1 | 1127442-82-3 | IWR-1-endo is a small-molecule inhibitor of Wnt signaling (IC50 of 180 nM in L-cells expressing Wnt3A) by stabilizing the Axin destruction complex with an EC50 of 0.2 μM. |
| CSN16481 | IWP-2 | 686770-61-6 | IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM. |
| CSN22864 | IWP-4 | 686772-17-8 | IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM. |
| CSN21406 | iCRT3 | 901751-47-1 | iCRT3 can inhibit both Wnt and β-catenin-responsive transcription. |
| CSN16814 | iCRT 14 | 677331-12-3 | iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. |
| CSN22412 | Gigantol | 67884-30-4 | Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. |
| CSN17195 | FH535 | 108409-83-2 | FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. |
| CSN26795 | CWP232228 | 1144044-02-9 | CWP232228 is a novel Wnt/β-Catenin inhibitor. It preferentially inhibits the growth of breast cancer stem-like cells. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. |
| CSN17991 | CCT251545 | 1661839-45-7 | CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. |
| CSN22741 | 6-Cyclohexyl-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 577696-37-8 | Cardionogen 1 is an inhibitor of Wnt/β-catenin signaling. |
| CSN12291 | BML-284 | 853220-52-7 | BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity. |
| CSN19238 | BML-284 hydrochloride | 2095432-75-8 | AMBMP HCl is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM. |
| CSN22337 | Adavivint | 1467093-03-3 | Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells. |
| CSN40412 | Prodigiosin hydrochloride | 56144-17-3 | |
| CSN35803 | Prodigiosin | 82-89-3 | |
| CSN33566 | HLY78 | 854847-61-3 | |
| CSN33458 | exo-IWR-1 | 1127442-87-8 | |
| CSN42991 | K-756 | 130017-40-2 | |
| CSN43858 | Dalosirvat | 1360540-81-3 | |
| CSN62561 | KY-02327 | 2093407-25-9 | |
| CSN66353 | G244-LM | 1563007-08-8 | |
| CSN67643 | Cirtuvivint | 2143917-62-6 | |
| CSN68061 | Ipivivint | 1481617-15-5 | |
| CSN75519 | IWP-3 | 687561-60-0 | |
| CSN85582 | YW1128 | 2131223-64-6 | |
| CSN106476 | Pyrvinium iodide | 35648-29-4 | |
| CSN104394 | 6-Cyclohexyl-3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 577983-92-7 |
