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Wnt
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN26794 | β-catenin/CBP-IN-1 | 1198780-38-9 | β-catenin/CBP-IN-1 is a potent and selective CBP/β-catenin antagonist, extracted from the patent WO2014092154A1. β-catenin/CBP-IN-1 has the potential for the study of liver fibrosis induced by hepatitis virus[1]. |
| CSN13998 | Xanthatin | 26791-73-1 | Xanthatin, a natural product isolated and purified from the fruits of Xanthium sibiricum with cytotoxic, antibacterial and antifungal activities, can inhibit murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. |
| CSN11885 | Salinomycin | 53003-10-4 | Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling. |
| CSN19163 | PNU-74654 | 113906-27-7 | PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. |
| CSN11650 | Pamidronic Acid | 40391-99-9 | Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis. |
| CSN23011 | NSC 668036 | 144678-63-7 | NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. |
| CSN23594 | Methyl Vanillate | 3943-74-6 | Methyl vanillate has ability to increase bone mass and activate wnt/β-catenin pathway. It can act as a potential lead anabolic agent for anti-osteoporosis drugs. |
| CSN13654 | IWR-1-Endo | 1127442-82-3 | IWR-1-endo is a small-molecule inhibitor of Wnt signaling (IC50 of 180 nM in L-cells expressing Wnt3A) by stabilizing the Axin destruction complex with an EC50 of 0.2 μM. |
| CSN22864 | IWP 4 | 686772-17-8 | IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM. |
| CSN12291 | BML-284 | 853220-52-7 | BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity. |
| CSN19238 | AMBMP HCl | 2095432-75-8 | AMBMP HCl is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM. |
