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Wnt

Wnt

货号 产品名 CAS号 信息
CSN26794 β-catenin/CBP-IN-1 1198780-38-9 β-catenin/CBP-IN-1 is a potent and selective CBP/β-catenin antagonist, extracted from the patent WO2014092154A1. β-catenin/CBP-IN-1 has the potential for the study of liver fibrosis induced by hepatitis virus[1].
CSN13998 Xanthatin 26791-73-1 Xanthatin, a natural product isolated and purified from the fruits of Xanthium sibiricum with cytotoxic, antibacterial and antifungal activities, can inhibit murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.
CSN11885 Salinomycin 53003-10-4 Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling.
CSN19163 PNU-74654 113906-27-7 PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
CSN11650 Pamidronicacid 40391-99-9 Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis.
CSN23011 NSC668036 144678-63-7 NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro.
CSN27659 Methyl 3-(4-methylbenzenesulfonamido)benzoate   173436-66-3 MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
CSN23594 Methyl vanillate 3943-74-6 Methyl vanillate has ability to increase bone mass and activate wnt/β-catenin pathway. It can act as a potential lead anabolic agent for anti-osteoporosis drugs.
CSN22542 4-(3-Phenylallyl)-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide 664969-54-4 LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 μM. It can disrupt the interaction between β-catenin and TCF4.
CSN19247 KYA1797K 1956356-56-1 KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).
CSN16086 KY02111 1118807-13-8 KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes.
CSN22870 JW67 442644-28-2 JW 67 is an inhibitor of canonical Wnt pathway signaling with IC50 of 1.17 μM.
CSN13654 IWR-1 1127442-82-3 IWR-1-endo is a small-molecule inhibitor of Wnt signaling (IC50 of 180 nM in L-cells expressing Wnt3A) by stabilizing the Axin destruction complex with an EC50 of 0.2 μM.
CSN16481 N-(6-Methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide 686770-61-6 IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM.
CSN22864 IWP-4 686772-17-8 IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM.
CSN21406 iCRT3 901751-47-1 iCRT3 can inhibit both Wnt and β-catenin-responsive transcription.
CSN16814 iCRT 14 677331-12-3 iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
CSN22412 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol 67884-30-4 Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.
CSN17195 FH535 108409-83-2 FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
CSN26795 CWP232228 1144044-02-9 CWP232228 is a novel Wnt/β-Catenin inhibitor. It preferentially inhibits the growth of breast cancer stem-like cells. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.
CSN17991 CCT251545 1661839-45-7 CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
CSN22741 Cardionogen 1 577696-37-8 Cardionogen 1 is an inhibitor of Wnt/β-catenin signaling.
CSN12291 BML-284 853220-52-7 BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity.
CSN19238 BML-284 HCl 2095432-75-8 AMBMP HCl is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
CSN40412 Prodigiosin HCl 56144-17-3
CSN35803 Prodigiosin 82-89-3
CSN33566 HLY78 854847-61-3
CSN33458 exo-IWR-1 1127442-87-8
CSN42991 K-756 130017-40-2
CSN43858 Dalosirvat 1360540-81-3
CSN62561 KY-02327 2093407-25-9
CSN66353 G244-LM 1563007-08-8
CSN67643 Cirtuvivint 2143917-62-6
CSN68061 Ipivivint 1481617-15-5
CSN75519 IWP-3 687561-60-0
CSN85582 YW1128 2131223-64-6
CSN106476 Pyrvinium Iodide 35648-29-4
CSN104394 CDMG1 577983-92-7
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