Calceolarioside B is a natural product isolated and purified from the herbs of Ajuga becumbens Thunb. with an anti-proliferation property.

3-bromo-5-phenyl Salicylic Acid is a cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively).

Soyasaponin Bb, a triterpenoid saponin that has been found in soy, selectively inhibits human recombinant renin (IC50 = 30 μg/ml). It can also inhibit the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM).

Statil is a selective and noncompetitive aldose reductase 2 inhibitor with Ki value of 7.7nM.

Zopolrestat is a aldose reductase inhibitor.

AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia.

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.

Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound.

Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.

Nodakenetin is a natural product isolated and purified from the herbs of Peucedanum decursivum Maxim. with clinical efficacy.