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Mc-Val-Ala-PAB
Mc-Val-Ala-PAB is a useful ADC linker conjugating for targeting drug delivery.
CC-90011 besylate
CC-90011 is a potent and orally active LSD1 inhibitor. It is in phase I clinical study of CC-90011 in patients (pts) with advanced unresectable solid tumors and R/R NHL.
EIDD-2801
EIDD-2801 is an orally bioavailable prodrug of EIDD-1931, which has a broad-spectrum antiviral activity against 39 multiple coronaviruses, including SARS-CoV2, MERS-CoV, SARS-CoV. and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to another nucleoside analog inhibitor.
Danicopan
Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
CADD522
CADD522 is a small molecule that inhibits the DNA binding of RUNX2. It negatively regulated transcription of RUNX2 target genes such as matrix metalloproteinase-13, vascular endothelial growth factor and glucose transporter-1, but upregulated RUNX2 expression by increasing RUNX2 stability. CADD522 may represent a potential antitumor drug.
OGG1 Inhibitor O8
O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG1-mediated catalysis but did not reduce DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.
Mycro-3
Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, orally, daily for 2 months) is approximately 30%.
MAC-545496
MAC-545496 is a nanomolar inhibitor of GraR. It reverses β-lactam resistance in the community-acquired MRSA USA300 strain.
VLX600
VLX600 is preferentially active against quiescent cells in colon cancer 3-D microtissues. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation and displays tumour growth inhibition in vivo.
JCN037
JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
特色产品更多
Calcifediol
Cilengitide
CPI-0610
CFI-402257
Lifitegrast
GLPG1690
AZD0364
AMG-3969
WT161
AZD0156
UNBS5162
AZD1981
BMS-309403
AM-0902
Risdiplam
TUG-1375
GSK-2894631A
DDD107498