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心血管疾病
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Mycro-3
Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, orally, daily for 2 months) is approximately 30%.
VLX600
VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation, potentiated the effect of radiation in tumor spheroids in a synergistic manner. VLX600 is preferentially active against quiescent cells in colon cancer 3-D microtissues. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation and displays tumour growth inhibition in vivo.
AZD5904
AZD5904 is a potent and irreversible MPO inhibitor with IC50 value of 140nM. Continuous subcutaneous AZD5904 infusion during the 2 week selectively blocked HFD (high-fat diet)'s microvascular effect.
RA-9
RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors。
NVP-2
NVP-2 is a potent and selective ATP-competitive CDK9 inhibitor with IC50 value of 0.5nM.
Col003
Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix.
BAY-885
BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM.
STAT3-IN-1
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis .
AMG 511
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model .
Orelabrutinib
Orelabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
特色产品更多
Calcifediol
Cilengitide
CPI-0610
CFI-402257
Lifitegrast
GLPG1690
AZD0364
AMG-3969
WT161
AZD0156
UNBS5162
AZD1981
BMS-309403
AM-0902
Risdiplam
TUG-1375
GSK-2894631A
DDD107498