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研究领域
癌症
心血管疾病
感染
代谢疾病
神经疾病
免疫/炎症
新产品更多
GLPG1690
GLPG1690, a first-in-class autotaxin (ATX) inhibitor with IC50 of 131 nM and Ki of 15 nMl, is able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice, and in reducing extra-cellular matrix deposition in the lung whilst also reducing LPA 18:2 content in bronchoalveolar lavage fluid and may be a possible effectvie compound in treating idiopathic pulmonary fibrosis.
CM-4620
CM4620 is a CRAC channel inhibitor to treat acute pancreatitis.
SM-164
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
TAPI-1
TAPI-1 is a specific TACE (TNF-α-converting enzyme) inhibitor.
GNE-3511
GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
AR-C155858
AR-C155858 is an inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and < 10 nM, respectively), and exhibits no activity at MCT4.
UVI 3003
UVI 3003 is a potent and selective RXR antagonist, used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer.
Ningetinib Tosylate
Ningetinib tosylate is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectively.
SGC-GAK-1
Acrizanib
Acrizanib is a selective VEGFR2 inhibitor with IC50 value of 17.4nM.
特色产品更多
Entinostat
Vorinostat
Selumetinib
GSK2126458
Docetaxel
Panobinostat
AZD8055
Cabazitaxel
Romidepsin
Alpelisib
ACY-1215
AZD2014
Cobimetinib
Palbociclib Isethionate
Pracinostat
LY2090314
IPI-549
Paclitaxel