Desoxyrhaponticin, a natural product isolated and purified from the roots of Rumex obtusifolius L., is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney, and is considered as promising fatty acid synthase(FAS) inhibitors, they could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells.

Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.

Ac-CoA Synthase Inhibitor is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM.

Isonicotinic acid hydrazide is an antibacterial agent used primarily as a tuberculostatic by blocking the action of fatty acid synthase by interacting with KatG.

Pedunculoside, a natural product isolated and purified from the barks of Ilex rotunda Thunb., has antiinflammation, heat-clearing, detoxifying, dehumidification, and odynolysis activities.

Coenzyme A is a coenzyme that plays an important role in the synthesis and oxidation of fatty acids.

TVB-3166 is an orally-available, reversible, potent, and selective FASN inhibitor.

Agrimol B is a natural product isolated and purified from the herbs of Agrimonia pilosa Ledeb.

FGH10019 is a sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM, displaying 5–10 times lower than the IC50 of fatostatin (~10 μM).