Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM.

Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.

Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.

alpha-Asarone is a naturally occuring inhibitor of both HMG-CoA reductase (IC50 = 3 mM) and certain isoforms of the cytochrome P450 superfamily of enzymes (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively), with neuroprotective, anti-oxidative, anticonvulsive and cognitive enhancing action.

Mevastatin is the first discovered statin-class HMG-CoA reductase inhibitor used as a cholesterol-lowering agent isolated from Penicillium citinium.

Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 5.6 μM.

Atorvastatin Hemicalcium is a potent HMG-CoA reductase inhibitor with IC50 value of 8 nM.

Swertiamarine is a naturally occuring secoiridoid glycoside which could inhibit HMG-CoA reductase activity.

Pitavastatin Calcium is a potent and competitive inhibitor of HMG-CoA reductase with Ki value of 1.7nM, which can block cholesterol synthesis.

Rosuvastatin Calcium is a competitive and synthetic HMG-CoA reductase inhibitor with IC50 value of 11 nM.

Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia.

Lovastatin is a HMG-CoA reductase used to treat high blood cholesterol and reduce the risk of cardiovascular disease, a naturally occuring fungal metabolite.

SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.

Clinofibrate is a HMG-CoA reductase inhibitor with IC50 value of 470 μM which can reduce plasma cholesterol levels and shows antihyperlipidemic effects.