Uric acid activates NFκB in a variety of cell culture models including proximal tubular cells. Uric acid suppresses 1-α hydroxylase mRNA and protein expression in dose dependent and time dependent manner.

Telotristat Etiprate an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

LP-533401 is an inhibitor of Tryptophan hydroxylase 1.

LX1606 is an orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Ro 61-8048 is an inhibitor of kynurenine 3-hydroxylase which can potently and competitively inhibit kynurenine 3-monooxygenase with Ki value and IC50 value of 4.8 nM and 37 nM, respectively.

Nepicastat HCl is a potent and selective dopamine β-hydroxylase (DBH) inhibitor with IC50 value of 9 nM.

Vitexin exhibits inhibition of carbohydrate hydrolase with IC50 of 244 μM and shows antioxidant activity in DPPH bleaching assay (IC50 = 24.2 μM). It is an apigenin flavone c-glycosidea isolated and purified from the seeds of Vitex trifolia L. with antinociceptive, antimyeloperoxidase, and anti-inflammatory activities.

Sapropterin 2HCl is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.

Tetrahydropapaverine HCl is a papaverine-derived inhibitor of TPH with the IC50 value of 5.7 μM.

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

Valpromide is a carboxamide derivative of valproic acid with anticonvulsant properties and used in the treatment of epilepsy and some affective disorders. It is also a potent inhibitor of liver microsomal epoxide hydrolase.

H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.

Scabertopin, a natural product isolated and purified from the herbs of Elephantopus scaber Linn., exhibits significant antitumor effect in vitro in a concentration-dependent manner.

UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor, exhibits highly active at 1 μM(81 ± 10% KMO inhibition), and is ineffective at blocking KAT activity.

LP-533401 HCl is an inhibitor of Tryptophan hydroxylase 1.