TEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and has little or no effect on PKM1, PKL and PKR.

PKR-IN-1 is a potent human R-type pyruvate kinase (PKR) inhibitor and also shows potency for mutant PKR including R510Q PKR, R532W PKR, T384W PKR etc.

PKR-IN-2 is a pyruvate kinase (PKR) activator with an IC50 of < 100 nM.

PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. It shows to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM).

Sodium monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.