SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

RORγt-IN-1 is a potent, orally bioavailable RORγt inhibitor with pIC50 of 8.4 and > 8.2 for RORγ FRET assay and Th17 assay.

SR1001 is a selective RORα and RORγ inverse agonist and inhibits TH17 cell differentiation and function.

SR-1078 is an agonist of RORα and RORγ and can increase transcriptional activity of RORα with 2 μM.

SR3335 can selectively bind to RORα and competitively inhibit the binding of 25-hydroxycholesterol to the ligand binding domain with Ki of 220 nM.

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.

GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator.

LYC-55716 is agonist of RAR-related orphan receptor γ (RORγ).