|(1S,3R,4R,5R)-3-(((-3-(3,4-二羟基苯基)丙烯酰基)氧基)-1,4,5-三羟基环己烷甲酸|CsnPharm

CAS No.: 327-97-9

绿原酸 Catalog No. CSN16293

Synonyms: 3-O-Caffeoylquinic acid;Heriguard;NSC-407296

Chlorogenic acid is one of the most abundant polyphenols in the human diet, has been reported to inhibit cancer cell growth and a major anti-inflammatory constituent of lonicerae flos extract.

规格	价格	促销价格	库存	数量

400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Chlorogenic acid is a phenolic compound from the hydroxycinnamic acid family and possesses many health-promoting properties such as anti-oxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive activities.in vivo, Mice were treated with vehicle, 250 mg/kg BW oral gavage metformin or 250 mg/kg BW chlorogenic acid intraperitoneally daily for 2 weeks.Chlorogenic acid inhibited hepatic glucose-6-phosphatase expression and activity, decreased hepatic steatosis, improved lipid profiles and skeletal muscle glucose uptake^[3].Moreover, Chlorogenic acid enhances the thermogenesis and proton leak of brown adipocytes and increases the number and the function of mitochondrial^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01400386	Healthy	Not Applicable	Completed	-	Switzerland ... more >> NESTEC/Clinical Development Unit / Metabolic Unit Lausanne 26, Vaud, Switzerland, 1000 Collapse <<
NCT00065715	Common Cold	Phase 3	Completed	-	United States, Wisconsin ... more >> University of Wisconsin-Madison Department of Family Medicine Madison, Wisconsin, United States, 53706-1490 Collapse <<
NCT03053986	Endothelial Dysfunction	Not Applicable	Recruiting	April 1, 2017	Italy ... more >> S. Orsola-Malpighi University Hospital Recruiting Bologna, Italy, 40038 Contact: Arrigo FG Cicero, MD, PhD ++39 512142224 arrigo.cicero@unibo.it Contact: Arrigo FG Cicero, MD, PhD ++39 3498558017 afgcicero@gmail.com Collapse <<

更多
参考文献

[1] Guo YJ, Luo T, et al. Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia. Life Sci. 2015 Apr 15;127:12-8.
[2] Chen WP, Wu LD. Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes. Int J Clin Exp Pathol. 2014 Dec 1;7(12):8797-801.
[3] Santana-Gálvez J, Cisneros-Zevallos L, Jacobo-Velázquez DA. Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Molecules. 2017 Feb 26;22(3):358. doi: 10.3390/molecules22030358. PMID: 28245635; PMCID: PMC6155416.
[4] Han X, Zhang Y, Guo J, You Y, Zhan J, Huang W. Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria. J Food Sci. 2019 Dec;84(12):3815-3824. doi: 10.1111/1750-3841.14838. Epub 2019 Nov 21. PMID: 31750946.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8224 mL
- 14.1120 mL
- 28.2240 mL
- 5 mM
- 0.5645 mL
- 2.8224 mL
- 5.6448 mL
- 10 mM
- 0.2822 mL
- 1.4112 mL
- 2.8224 mL

技术信息

CAS号

327-97-9

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H18O9

运输

蓝冰

分子量

354.31

别名

3-O-Caffeoylquinic acid;Heriguard;NSC-407296;Chlorogenic Acid;3(34Dihydroxycinnamoyl)quinate;3(34Dihydroxycinnamoyl)quinic acid;3Caffeoylquinate;3Caffeoylquinic acid;3CQA;Chlorogenate;3transCaffeoylquinic acid;绿原酸

溶解度

DMSO	95.0 mg/mL (268.1 mM) warming

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01400386	Healthy	Not Applicable	Completed	-	Switzerland ... more >> NESTEC/Clinical Development Unit / Metabolic Unit Lausanne 26, Vaud, Switzerland, 1000 Collapse <<
NCT00065715	Common Cold	Phase 3	Completed	-	United States, Wisconsin ... more >> University of Wisconsin-Madison Department of Family Medicine Madison, Wisconsin, United States, 53706-1490 Collapse <<
NCT03053986	Endothelial Dysfunction	Not Applicable	Recruiting	April 1, 2017	Italy ... more >> S. Orsola-Malpighi University Hospital Recruiting Bologna, Italy, 40038 Contact: Arrigo FG Cicero, MD, PhD ++39 512142224 arrigo.cicero@unibo.it Contact: Arrigo FG Cicero, MD, PhD ++39 3498558017 afgcicero@gmail.com Collapse <<
NCT01734070	Inflammation ... more >>Cardiovascular Diseases Collapse <<	Not Applicable	Completed	-	United States, California ... more >> USDA, ARS, Western Human Nutrition Research Center Davis, California, United States, 95616 Collapse <<
NCT03127670	Arsenical Keratosis	Phase 2	Completed	-	Bangladesh ... more >> Bhanga Faridpur, Bangladesh, 7830 Collapse <<
NCT01832662	Healthy	Not Applicable	Completed	-	-
NCT01813981	Cardiovascular Disease	Not Applicable	Completed	-	United Kingdom ... more >> Department of Food and Nutritional Sciences Reading, Berkshire, United Kingdom, RG6 6AP University of Reading Reading, England, United Kingdom, RG6 6UR Collapse <<
NCT01089920	Healthy	Not Applicable	Completed	-	Switzerland ... more >> Nestle Research Center Lausanne, Switzerland, 1000 Collapse <<
NCT02417519	Oral Glucose Tolerance	Not Applicable	Completed	-	Denmark ... more >> Department of Nutrition, Exercise and Sports, University of Copenhagen Frederiksberg, Denmark, 1958 Collapse <<
NCT03265184	Metabolic Syndrome	Not Applicable	Completed	-	-
NCT02764957	Metabolic Syndrome	Phase 2 Phase 3	Completed	-	Iran, Islamic Republic of ... more >> NNFTRI clinic Tehran, Iran, Islamic Republic of, 19435 Collapse <<
NCT01832701	Healthy	Not Applicable	Completed	-	Switzerland ... more >> Clinical Development Unit / Metabolic Unit Lausanne, Switzerland, 1000 Collapse <<
NCT01912144	Bioavailability ... more >> Cardiovascular Health Status Collapse <<	Not Applicable	Completed	-	United Kingdom ... more >> School of Food Science, University of Leeds Leeds, West Yorkshire, United Kingdom, LS2 9JT Collapse <<
NCT01523028	Healthy	Not Applicable	Completed	-	Germany ... more >> University of Kaiserslautern Kaiserslautern, Germany, D-67663 Collapse <<
NCT02388672	Blood Pressure	Not Applicable	Withdrawn(Personnel changes)	-	-
NCT02887950	Overweight	Not Applicable	Recruiting	September 2018	Italy ... more >> Fondazione IRCCS Policlinico San Matteo Recruiting Pavia, Italy, 27100 Contact: Riccardo Caccialanza, MD Sub-Investigator: Emanuele Cereda, MD, PhD Sub-Investigator: Rossella Elena Nappi, MD Collapse <<
NCT03019263	Dyslipidemia	Not Applicable	Completed	-	Italy ... more >> Fondazione IRCCS Policlinico San Matteo Pavia, Italy, 27100 Collapse <<
NCT03520452	Endothelial Dysfunction	Not Applicable	Active, not recruiting	January 2019	Australia, Perth ... more >> University of Western Australia Crawley, Perth, Australia, 6009 Collapse <<
NCT03444558	Metabolic Syndrome	Not Applicable	Completed	-	Italy ... more >> University Hospital of Palermo Palermo, Palrmo, Italy, 90127 Collapse <<
NCT03214276	Healthy	Not Applicable	Completed	-	-
NCT03758014	GBM	Phase 2 Phase 3	Recruiting	April 30, 2021	China, Beijing ... more >> Beijing Tiantan Hospital, Capital Medical University Recruiting Beijing, Beijing, China Contact: Wenbin Li Collapse <<
NCT02621060	Impaired Glucose Tolerance	Phase 2	Unknown	February 2017	Mexico ... more >> Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara Recruiting Guadalajara, Jalisco, Mexico, 44340 Collapse <<
NCT02136342	Advanced Cancer	Phase 1	Terminated(Study site change)	-	-
NCT02245204	Advanced Cancer	Phase 1	Completed	-	China ... more >> Beijing Cancer Hospital Beijing, China, 100142 Collapse <<
NCT02524938	Diabetes Mellitus, Type 2 ... more >> Renal Insufficiency, Chronic Collapse <<	Not Applicable	Recruiting	March 2018	United Kingdom ... more >> NHS Greater Glasgow and Clyde Recruiting Glasgow, United Kingdom University of Glasgow Recruiting Glasgow, United Kingdom Collapse <<
NCT02728349	Glioblastoma	Phase 1	Completed	-	China ... more >> Beijing Shijitan Hospital,Capital Medical University Beijing, China, 100038 Collapse <<
NCT02929901	Type 2 Diabetes Nonalcoholic F... more >>atty Liver Collapse <<	Phase 2 Phase 3	Unknown	December 2017	Iran, Islamic Republic of ... more >> NNFTRI clinic Tehran, Iran, Islamic Republic of, 19435 Collapse <<
NCT03751592	Advanced Lung Cancer	Phase 1 Phase 2	Recruiting	April 30, 2021	China ... more >> Cancer Hospital Chinese Academy of Medical Sciences Recruiting Beijing, China, 100021 Principal Investigator: Yuankai Shi, Dr Collapse <<

绿原酸 Catalog No. CSN16293

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