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CAS No.: 13190-97-1

茄尼醇 Catalog No. CSN20842

Synonyms: Nonaisoprenol;Betulanonaprenol

Solanesol is a C45 isoprenoid alcohol, it is the most abundant lipid in tobacco leaves and may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke.

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技术信息

生物活性

描述Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase regulating cell adhesion, migration and proliferation. Solanesol is a non-cyclic polyisoprenoid alcohol found mainly in solanaceous crops that acts as a FAK inhibitor. When human hepatic cell L02 were treated with different doses of solanesol (10 – 80 µM) for 12 hours or 80 µM solanesol for various hours (3 – 24 hours), the mRNA expressions of HO-1 and Hsp70 were gradually elevated after solanesol incubation. The protein levels of HO-1 and Hsp70 were also increased in a concentration-dependent manner in solanesol-treated group. The incubation of 80 µM solanesol for 12 hours significantly down-regulated the cytosolic protein level of Nrf2 in L02 cells, but increased Nrf2 expression in nucleus. The same treatment of solanesol also enhanced the activity of ARE promoter in L02 cells with statistical significance. Twelve hours post incubation of 80 µM solanesol, L02 cells showed increased Hsp90-Keap1 interaction compared to Hsp90 inhibitor-treated cells. Solanesol treatment also resulted in the loss of Keap1-Cul3/Rbx1 interaction, the blockage of Keap1-Nrf2 interaction, and the reduction of Nrf2 ubiquitination and degradation. Solanesol at the concentrations of 40 or 80 µM significantly decreased cytosolic HSF1 expression, and up-regulated nuclear protein level of HSF1 in L02 cells after 12-hour incubation. Compared to control cells, the exposure of 80 µM solanesol for 12 hours reduced the interaction of HSF1 with Hsp70 and Hsp90, elevated the interaction of Hsp70 with Hsp40 and CHIP, and enhanced the interaction of Hsp90 with p23 and CHIP.
作用机制The hydroxyl end of solanesol binds to the binding site of ATP, thereby inhibiting the phosphorylation of FAK.
动物研究
剂量
Rat: 5 mg/kg - 15 mg/kg^[1] (p.o.)； 40 mg/kg, 60 mg/kg^[2] (p.o.)

给药途径
p.o.
临床研究

动物研究
剂量	Rat: 5 mg/kg - 15 mg/kg^[1] (p.o.)； 40 mg/kg, 60 mg/kg^[2] (p.o.)
给药途径	p.o.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02228824	Smoking	Not Applicable	Completed	-	United States, Pennsylvania ... more >> Smoking Research Group, University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT02228824	-	-	Completed	-	-
NCT02990455	Alcohol Drinking ... more >> Cigarette Smoking Toxicity Collapse <<	Phase 1	Recruiting	December 2019	United States, Maryland ... more >> Battelle Memorial Institute Recruiting Baltimore, Maryland, United States, 21209 Contact: Carson Smith, MPH 410-372-2705 smithc@battelle.org Contact: Zachary Rosenberry, MPH 410-372-2726 rosenberryz@battelle.org Principal Investigator: Erica N Peters, PhD Collapse <<

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5846 mL
- 7.9231 mL
- 15.8461 mL
- 5 mM
- 0.3169 mL
- 1.5846 mL
- 3.1692 mL
- 10 mM
- 0.1585 mL
- 0.7923 mL
- 1.5846 mL

技术信息

CAS号

13190-97-1

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C45H74O

运输

蓝冰

分子量

631.07

别名

Nonaisoprenol;Betulanonaprenol

溶解度

DMSO	insoluble
Water	insoluble
Ethanol	insoluble

动物实验配方

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