|(2R,3S,4S,5R,6S)-2-(羟甲基)-6-(4-羟基苯氧基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 497-76-7

熊果苷 Catalog No. CSN11495

Synonyms: 熊果苷;β-Arbutin

Arbutin is an inhibitor of tyrosinase with IC50 of 1.09 mM and can prevent the formation of melanin. It is a glycosylated hydroquinone found in the leaves of arctostaphylos uvaursi.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Tyrosinase

IC50:1.09mM
描述Arbutin is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents^[3]. Arbutin inhibited the tyrosinase activity of cultured human melanocytes at noncytotoxic concentrations. It did not affect the expression of tyrosinase mRNA^[4]. Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner. Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM^[5]. Arbutin inhibits OS (osteosarcoma) cell proliferation, migration and invasion via miR-338-3p/MTHFD1L and by inactivating the AKT(phosphorylated-protein kinase B)/mTOR (phosphorylated-mammalian target of rapamycin) pathway^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02945891	Cervical Cancer	Not Applicable	Active, not recruiting	December 2018	Norway ... more >> Ostfold Hospital Trust Fredrikstad, Norway Oslo University Hospital, Molecular Pathology Oslo, Norway Oslo University Hospital, Ullevål Oslo, Norway Radiumhospital Oslo, Norway Collapse <<
NCT00781625	Urinary Tract Infections	Not Applicable	Unknown	December 2010	Norway ... more >> Akershus Universitetssykehus HF Recruiting Lørenskog, Akershus, Norway, 1478 Contact: Caroline U Skagemo, MD +47 02900111 cask@ahus.no Contact: Gunn Iren Meling, PhD, MD +47 02900 111 gmel@ahus.no Principal Investigator: Caroline U Skagemo, MD St.Olavs Hospital Active, not recruiting Trondheim, Norway, 7006 Collapse <<
NCT02130713	Chronic Bacterial Prostatitis	Phase 4	Completed	-	Italy ... more >> policlinico Umberto I - Department of Gynecological-Obstetrics Sciences and Urological Sciences Roma, Italy, 00161 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6731 mL
- 18.3654 mL
- 36.7308 mL
- 5 mM
- 0.7346 mL
- 3.6731 mL
- 7.3462 mL
- 10 mM
- 0.3673 mL
- 1.8365 mL
- 3.6731 mL

技术信息

CAS号

497-76-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H16O7

运输

蓝冰

分子量

272.25

别名

熊果苷;β-Arbutin

溶解度

DMSO	54.0 mg/mL (198.3 mM)
Water	53.0 mg/mL (194.7 mM)
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02945891	Cervical Cancer	Not Applicable	Active, not recruiting	December 2018	Norway ... more >> Ostfold Hospital Trust Fredrikstad, Norway Oslo University Hospital, Molecular Pathology Oslo, Norway Oslo University Hospital, Ullevål Oslo, Norway Radiumhospital Oslo, Norway Collapse <<
NCT00781625	Urinary Tract Infections	Not Applicable	Unknown	December 2010	Norway ... more >> Akershus Universitetssykehus HF Recruiting Lørenskog, Akershus, Norway, 1478 Contact: Caroline U Skagemo, MD +47 02900111 cask@ahus.no Contact: Gunn Iren Meling, PhD, MD +47 02900 111 gmel@ahus.no Principal Investigator: Caroline U Skagemo, MD St.Olavs Hospital Active, not recruiting Trondheim, Norway, 7006 Collapse <<
NCT02130713	Chronic Bacterial Prostatitis	Phase 4	Completed	-	Italy ... more >> policlinico Umberto I - Department of Gynecological-Obstetrics Sciences and Urological Sciences Roma, Italy, 00161 Collapse <<
NCT02934724	-	-	Active, not recruiting	December 2018	Norway ... more >> Oslo University Hospital, Cancer Registry of Norway Oslo, Norway, 0379 Collapse <<
NCT01538550	Colorectal Cancer ... more >> Colorectal Adenomas Collapse <<	Not Applicable	Recruiting	December 2030	Norway ... more >> Moss Hospital Recruiting Oslo, Norway, 1535 Contact: Anita Jørgensen, RN +4793089107 anita.jorgensen@kreftregisteret.no Contact: Thomas de Lange, MD, PhD +4799030789 t.d.lange@medisin.uio..no Sub-Investigator: Thomas deLange, MD,PhD Principal Investigator: Per Sandvei, MD Bærum County Hospital Enrolling by invitation Rud, Norway, 1309 Collapse <<
NCT00717652	Melasma	Phase 2 Phase 3	Suspended	-	Brazil ... more >> Lal Clinica Pesquisa E Desenvolvimento Ltda Valinhos, S, Brazil, 13270000 Collapse <<

熊果苷 Catalog No. CSN11495

靶点选择性

请登录您的专属账户

确认信息