生物活性

• 描述Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco^[3]. Isoliquiritigenin inhibited rat lens aldose reductase with an IC50 of 3.2 x 10(-7) M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells, with an IC50 of 2.0 x 10(-6) M^[4]. Isoliquiritigenin treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia. Moreover, Isoliquiritigenin reduced the mitochondrial potential (Δψ) of isolated mouse cardiomyocytes^[3]. Isoliquiritigenin also showed the most potent inhibition of mouse rectal contraction induced by CCh(carbamylcholine) with an IC50 value of 1.70+/-0.07 microM^[5].
• 细胞研究
• Cell Data

  Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
  CHO cells	-	Cytotoxicity assay	-	Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM	19572738
  colon 26-L5 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM	18440233
  dog MDCK cells	20 ug/mL	Function assay	1 h	Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control	22743086

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• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00193154	Kidney Cancer	Phase 2	Completed	-	United States, Louisiana ... more >> Medical Oncology LLC Baton Rouge, Louisiana, United States, 70809 United States, Michigan Grand Rapids Oncology Program Grand Rapids, Michigan, United States, 49503 Collapse <<
  NCT03501381	Renal Cell Carcinoma	Phase 2	Recruiting	April 2023	United States, Indiana ... more >> Indiana Univeristy Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Roberto Pili, MD    317-278-7776    rpili@iu.edu    Principal Investigator: Roberto Pili, MD          United States, Nebraska Nebraska Methodist Hospital Recruiting Omaha, Nebraska, United States, 68114 Contact: Craig Ryan       craig.ryan@nmhs.org    Principal Investigator: Ralph Hauke, MD Collapse <<
  NCT03552380	Renal Cell Carcinoma	Phase 2	Recruiting	August 2020	United States, Indiana ... more >> Indiana Univeristy Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Roberto Pili, MD    317-278-7776    rpili@iu.edu    Principal Investigator: Roberto Pili, MD Collapse <<

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• 参考文献

• [1] Nerya O, Vaya J, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7.

  [2] Aida K, Tawata M, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.

  [3] Zhang X, Zhu P, Zhang X, Ma Y, Li W, Chen JM, Guo HM, Bucala R, Zhuang J, Li J. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. doi: 10.1155/2013/390890. Epub 2013 Sep 16. PMID: 24163504; PMCID: PMC3791876.

  [4] Aida K, Tawata M, Shindo H, Onaya T, Sasaki H, Yamaguchi T, Chin M, Mitsuhashi H. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. doi: 10.1055/s-2006-960950. PMID: 2118267.

  [5] Sato Y, He JX, Nagai H, Tani T, Akao T. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. doi: 10.1248/bpb.30.145. PMID: 17202675.

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