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CAS No.: 130929-57-6
Synonyms: OR-611;Comtan;HSDB-8251
Entacapone is a specific, potent and peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00406029 | Parkinson Disease ... more >> Movement Disorders Central Nervous System Diseases Neurodegenerative Diseases Brain Diseases Collapse << | Phase 2 | Completed | - | - |
NCT00406029 | - | - | Completed | - | - |
NCT02994719 | - | - | Recruiting | October 2019 | United States, Massachusetts ... more >> Clinical Research Center BIDMC Recruiting Boston, Massachusetts, United States, 02215 Collapse << |
实验方案
技术信息
CAS号 | 130929-57-6 | 储存条件 |
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分子式 | C14H15N3O5 | 运输 | 蓝冰 | |||||||||||||
分子量 | 305.29 | 别名 | OR-611;Comtan;HSDB-8251;恩他卡朋 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00406029 | Parkinson Disease ... more >> Movement Disorders Central Nervous System Diseases Neurodegenerative Diseases Brain Diseases Collapse << | Phase 2 | Completed | - | - |
NCT00406029 | - | - | Completed | - | - |
NCT02994719 | - | - | Recruiting | October 2019 | United States, Massachusetts ... more >> Clinical Research Center BIDMC Recruiting Boston, Massachusetts, United States, 02215 Collapse << |
NCT00282152 | Parkinson's Disease | Not Applicable | Completed | - | - |
NCT00044083 | Schizophrenia | Phase 2 | Terminated(Scientific Director... more >> request to use resources for other studies) Collapse << | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00537017 | Parkinson Disease ... more >> Neurodegenerative Diseases Central Nervous System Diseases Movement Disorders Brain Diseases Collapse << | Phase 2 | Completed | - | - |
NCT00693862 | Pharmacokinetics | Phase 1 | Completed | - | Finland ... more >> NEURO Helsinki, Finland, 00250 Pharmacokinetics laboratory/Department of Pharmacology and Toxicology Kuopio, Finland, 70211 Turku University Hospital Turku, Finland, 20521 Collapse << |
NCT01766258 | Parkinson's Disease | Phase 2 | Completed | - | - |
NCT00262470 | Tachycardia C... more >>hronic Orthostatic Intolerance Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 2021 | United States, Tennessee ... more >> Vanderbilt University Autonomic Dysfunction Center Nashville, Tennessee, United States, 37232-2195 Collapse << |
NCT01520727 | Parkinson Disease | Phase 1 | Completed | - | France ... more >> BIOTRIAL Rennes, France, F-35000 Collapse << |
NCT00537017 | - | - | Completed | - | - |
NCT00044083 | - | - | Terminated(Scientific Director... more >> request to use resources for other studies) Collapse << | - | - |
NCT01520727 | - | - | Completed | - | - |
NCT02554734 | Parkinson's Disease | Phase 1 | Completed | - | Finland ... more >> Clinical Research Services Turku CRST Turku, Finland Collapse << |
NCT00125567 | Idiopathic Parkinson's Disease | Phase 4 | Completed | - | Denmark ... more >> Aalborg Hospital Aalborg, Denmark, DK-9000 Aalborg Bispebjerg Hospital Copenhagen, Denmark Århus Kommunehospital Nørrebrogade 44, Denmark, 8000 Finland South Karelia Central Hospital Lappeenranta, Finland Tampere University Hospital Tampere, Finland, 33521 Tampere Germany Parkinson Klinik Bad Nauheim Bad Nauheim, Germany, 61231 Bad Nauheim Neurologische Klinik Bad Neustadt Bad Neustadt, Germany, 97616 Bad Neustadt Neurologische Klinik der Universitat Dusseldorf Duesseldorf, Germany, 40225 Duesseldorf Allgemeines Krankenhaus Harburg Hamburg, Germany, 21075 Hamburg Praxis Drs Lang, Krauss, Schreiber Ulm, Germany, 89073 Ulm Ireland Mater Private Hospital Dublin, Ireland, Dublin 7 Sweden Universitetssjukhuset MAS Malmö, Sweden, SE-205 02 Läkarhuset Vällingby Vällingby, Sweden, SE-162 68 United Kingdom Movement Disorder Services Chertsey, Surrey, United Kingdom, KT16 0QA University Hospital of Wales Cardiff, Wales, United Kingdom, CF14 4XW Glan Clwyd Hospital Rhyl, Wales, United Kingdom, CF14 4XW Frenchay Hospital Bristol, United Kingdom, BS16 1LE Leigh Infirmary Leigh, United Kingdom, WN7 1HS Southampton General Hospital Southampton, United Kingdom, SO16 6YD Collapse << |
NCT00282152 | - | - | Completed | - | - |
NCT01070628 | Parkinson's Disease | Phase 1 | Completed | - | Finland ... more >> Phase I Unit, Orion Pharma Espoo, Finland, 02101 Collapse << |
NCT00906828 | Parkinson Disease | Phase 4 | Completed | - | Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, 75646 Collapse << |
NCT00491998 | Parkinson's Disease | Phase 1 Phase 2 | Completed | - | Italy ... more >> IRCCS San Raffaele Pisana Roma, Rome, Italy, 00163 Collapse << |
NCT00199394 | Parkinson's Disease | Phase 3 | Completed | - | United Kingdom ... more >> Kyowa Hakko UK Ltd. Slough, Berkshire, United Kingdom, SL14 DX Collapse << |
NCT00562198 | Parkinson´s Disease | Phase 2 | Terminated(Illogistical result... more >>s found in interim evaluation.) Collapse << | - | Finland ... more >> Helsinki University Hospital, Department of Neurology Helsinki, Finland, 00029 Oulu University Hospital, Department of Neurology Oulu, Finland, 90220 Porin Lääkäritalo Pori, Finland, 28100 FinnMedi Tutkimus Oy Tampere, Finland, 33520 CRST Turku, Finland, 20520 Collapse << |
NCT01519284 | Parkinson Disease | Phase 1 | Completed | - | Portugal ... more >> Bial - Portela & Cª, S.A. S. Mamede do Coronado, Portugal, 4745-457 Collapse << |
NCT02764125 | Parkinson's Disease | Phase 2 | Completed | - | Finland ... more >> Clinical Research Services Turku CRST Turku, Finland, 20520 Germany Study Coordinating Investigator Harleshausen, Kassel, Germany, 34128 Hungary Semmelweis Egyetem Neurológiai Klinika Budapest, Hungary, 1083 Latvia Investigator Riga, Latvia, LV1012 Collapse << |
NCT03103399 | Parkinson Disease | Phase 2 | Completed | - | - |
NCT02170376 | - | - | Completed | - | - |
NCT00200447 | Parkinson's Disease | Phase 2 | Completed | - | - |
NCT01688089 | Healthy | Phase 1 | Completed | - | Germany ... more >> Parexel International GmbH Berlin, Germany Collapse << |
NCT03091868 | Parkinson Disease | Phase 1 | Completed | - | Portugal ... more >> Human Pharmacology Unit (UFH) S. Mamede do Coronado, Portugal, 4745-457 Collapse << |
NCT02070887 | - | - | Unknown | - | Switzerland ... more >> University Hospital Zurich, Division of Neurology Recruiting Zurich, ZH, Switzerland, 8091 Contact: Christian Baumann, MD christian.baumann@usz.ch Sub-Investigator: Michael Sommerauer, MD Collapse << |
NCT00360308 | Parkinson's Disease | Phase 3 | Terminated(Study stopped due t... more >>o lack of efficacy.) Collapse << | - | France ... more >> Pavillon Riser- Hopital Purpan Toulouse Cedex, France, 31059 Collapse << |
NCT02170376 | Parkinson's Disease (PD) | Phase 1 | Completed | - | France ... more >> SGS aster Paris, France, 75015 Collapse << |
NCT01840423 | Healthy | Phase 1 | Completed | - | Germany ... more >> Parexel International GmbH Berlin, Germany Collapse << |
NCT00360308 | - | - | Terminated(Study stopped due t... more >>o lack of efficacy.) Collapse << | - | - |
NCT01519284 | - | - | Completed | - | - |
NCT01468012 | Cocaine Dependence | Phase 2 Phase 3 | Completed | - | United States, New York ... more >> STARS New York, New York, United States, 10032 Collapse << |
NCT03094156 | Parkinson Disease | Phase 1 | Completed | - | Portugal ... more >> Human Pharmacology Unit (UFH) - BIAL - Portela & Cª, SA S. Mamede do Coronado, Portugal, 4745-457 Collapse << |
NCT01468012 | - | - | Completed | - | - |
NCT01568073 | Parkinson's Disease | Phase 3 | Completed | - | Portugal ... more >> Bial - Portela & Cª, S.A. S. Mamede do Coronado, Portugal, 4745-457 Collapse << |
NCT00245700 | - | - | Completed | - | United Kingdom ... more >> Southern General Hospital Glasgow, Scotland, United Kingdom, G51 4TF Collapse << |
NCT01568073 | - | - | Completed | - | - |
NCT00247247 | Parkinson's Disease | Phase 4 | Completed | - | Germany ... more >> Orion Pharma GmbH Hamburg, Germany, 22607 Hamburg Collapse << |
NCT01130493 | Parkinson's Disease | Phase 3 | Completed | - | United States, California ... more >> Margolin Brain Institute Fresno, California, United States, 93720 The Parkinson's Institute in Sunnyvale Sunnyvale, California, United States, 94085 United States, Florida UM Movement Disorders Center Miami, Florida, United States, 33136 Charlotte Neurological Services Port Charlotte, Florida, United States, 33980 USF Parkinson's and Movement Disorders Center Tampa, Florida, United States, 33606 United States, Michigan Quest Research Institute Bingham Farms, Michigan, United States, 48025 United States, Nevada University Health Systems Las Vegas, Nevada, United States, 89102 United States, New York Parkinson's Disease and Movement Disorders Center of Long Island Commack, New York, United States, 11725 Kingston Neurological Associates Kingston, New York, United States, 12401 United States, Ohio University Neurology, Inc Cincinnati, Ohio, United States, 45219 United States, Virginia Sentara Neurological Associates Virginia Beach, Virginia, United States, 23456 United States, Washington Booth Gardner Parkinson's Care Center Kirkland, Washington, United States, 98034 France Hôpital Gabriel Montpied-Service de Neurologie A- Clermont-Ferrand Cedex 1, France, 63003 Service de neurologie-Hôpital de la Timone- Marseille, France, 13385 Germany Praxis für Neurologie, Psychiatrie und Psychotherapie Achim Achim, Germany, 28832 Praxis Dres. Bitter/Schumann Bochum, Germany, 44805 Klinikum rechts der Isar der Technischen Universität München München, Germany, 81675 Klinik für Neurologie, Stadtroda Stadtroda, Germany, 07646 RKU, Neurologische Klinik der Universität Ulm Ulm, Germany, 89081 Italy Casa di Cura Villa Margherita Arcugnano, Italy, 36057 San Raffaele Cassino, San Raffaele Cassino, Cassino, Italy, 03043 Dipartimento di Oncologia e Neuroscienze, Università G. D'Annunzio Chieti, Italy, 66013 Ospedale della Misericordia Grosseto, Italy, 58100 IRCCS San Raffaele Pisana Roma, Italy, 163 Collapse << |
NCT01158950 | Impulsive Behavior | Not Applicable | Active, not recruiting | June 2019 | United States, California ... more >> University of California, Berkeley Berkeley, California, United States, 94704 UCSF: Ernest Gallo Clinic and Research Center Emeryville, California, United States, 94591 Collapse << |
NCT02834507 | Parkinson's Disease (PD) | Phase 2 | Completed | - | - |
NCT01130493 | - | - | Completed | - | - |
NCT01296464 | Parkinson's Disease | Phase 2 | Completed | - | Finland ... more >> Kanta-Hämeen keskussairaala Hämeenlinna, Finland, 13530 ODL Terveys Oy (ODL) Oulu, Finland, 90100 Porin Lääkäritalo Pori, Finland, 28100 Sweden Länssjukhuset Ryhov, Medicin/Neurologmottagningen Jönköping, Sweden, SE-55185 Karolinska Universitetssjukhuset Solna, Neurologkliniken Stockholm, Sweden, SE-171 76 Collapse << |
NCT00134966 | Parkinson's Disease | Phase 3 | Completed | - | - |
NCT02448914 | Parkinson's Disease | Phase 1 | Completed | - | Sweden ... more >> Clinical Trial Consultants AB Uppsala, Sweden, SE-75185 Collapse << |
NCT02448914 | - | - | Completed | - | - |
NCT02452606 | Parkinson Disease ... more >> Sleep Disorders Collapse << | Not Applicable | Unknown | May 2017 | Korea, Republic of ... more >> Asan Medical Center Recruiting Seoul, Korea, Republic of, 05505 Contact: Sun Ju Chug, Professor 82-2-3010-3988 sunjubrain@gmail.com Collapse << |
NCT00415844 | Healthy | Phase 1 | Completed | - | Germany ... more >> Novartis Investigative Site Nuernberg, Germany Collapse << |
NCT00143026 | Parkinson's Disease | Phase 4 | Completed | - | Australia ... more >> Royal Adelaide Hospital Adelaide, Australia Watkins Medical Center Brisbane, Australia Central Coast Neuroscience Research Gosford, Australia Heidelberg Repatriation Hospital Melbourne, Australia Monash Medical Centre Melbourne, Australia Sir Charles Gairdner Hospital Perth, Australia Concord Hospital Sydney, Australia Southern Neurology, St. George Private Hospital Sydney, Australia Westmead Hospital Sydney, Australia Philippines St. Luke's Medical Centre Manila, Philippines University of Santo Tomas Hospital Manila, Philippines Taiwan Chang Gung Memorial Hospital Linkou, Taiwan Kaohsiung Medical University, Chung-Ho Memorial Hospital Linkou, Taiwan National Taiwan University Hospital Linkou, Taiwan Thailand King Chulalongkorn Memorial Hospital Bangkok, Thailand Maharaj Nakorn Chiangmai Hospital Bangkok, Thailand Siriraj Hospital Bangkok, Thailand Pharmongkutklao Army Hospital Bankok, Thailand Collapse << |
NCT00601978 | Parkinson's Disease | Phase 4 | Withdrawn(Business decision br... more >>and strategy; no patients enrolled) Collapse << | - | - |
NCT00415831 | Healthy | Phase 1 | Completed | - | Germany ... more >> Novartis Investigative Site Nuernberg, Germany Collapse << |
NCT00415740 | Healthy | Phase 1 | Completed | - | Germany ... more >> Novartis Investigative Site Nuernberg, Germany Collapse << |
NCT00099268 | Parkinson's Disease | Phase 3 | Completed | - | - |
NCT00219284 | Parkinson's Disease With End o... more >>f Dose Wearing Off Collapse << | Phase 4 | Completed | - | - |
NCT01437293 | Cocaine Abuse | Phase 1 | Completed | - | United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse << |
NCT00415922 | Healthy | Phase 1 | Completed | - | Germany ... more >> Novartis Investigative Site Nuernberg, Germany Collapse << |
NCT00642356 | - | - | Terminated(slow enrollment) | - | - |
NCT00642356 | Parkinson's Disease | Phase 4 | Terminated(slow enrollment) | - | United States, Arizona ... more >> Xenoscience, Inc Phoenix, Arizona, United States, 85004 United States, California South Coast Health Center Aliso Viejo, California, United States, 92656 University of California Irvine, California, United States, 92697 Coastal Neurological Medical Group, Inc La Jolla, California, United States, 92037 United States, District of Columbia Georgetown University Hospital Washington, District of Columbia, United States, 20007 United States, Florida Sunrise Clinical Research, Inc Hollywood, Florida, United States, 33021 Charlotte Neurological Services Port Charlotte, Florida, United States, 33952 United States, Kansas Cotton O'Neil Clinic Topeka, Kansas, United States, 66606 United States, Maryland University of Maryland School of Medicine Baltimore, Maryland, United States, 21201 United States, Missouri Neurology, Inc Columbia, Missouri, United States, 65201 Dr. John's Mercy Medical Center St. Louis, Missouri, United States, 63141 United States, Nebraska Creighton U Medical Center, Dept of Neurology Omaha, Nebraska, United States, 68131 United States, New York Parkinson's Disease & Movement Disorders Commack, New York, United States, 11725 Central New York Research Corporation Syracuse, New York, United States, 13210 Neurological Care of Central NY Syracuse, New York, United States, 13210 United States, North Carolina Duke University Durham, North Carolina, United States, 27705 United States, Pennsylvania Neurology Associates Monroeville, Pennsylvania, United States, 15146 University of Pittsburg Pittsburg, Pennsylvania, United States, 15213 United States, Texas University of Texas Southwestern Dallas, Texas, United States, 75390 University of Texas Medical School Houston, Texas, United States, 77030 Scott & White Hospital Temple, Texas, United States, 76508 Collapse << |
NCT00391898 | Parkinson's Disease | Phase 4 | Completed | - | Spain ... more >> Hospital Universitario Principe de Asturias Alcalá de Henares, Madrid, Spain, 28805 Fundación Hospital de Alcorcón Alcorcón (Madrid, Spain, 28922 Hospital General de Alicante Alicante, Spain, 03010 Centro Médico Teknon Barcelona, Spain, 08022 Hospital de la Santa Creu i de Sant Pau Barcelona, Spain, 08025 Hospital Vall d'Hebron Barcelona, Spain, 08025 Hospital Clínic i Provincial de Barcelona Barcelona, Spain, 08036 Corporació Sanitària Parc Taulí Sabadell Barcelona, Spain, 08208 Hospital General Yagüe Burgos, Spain, 09005 Hospital Universitario Virgen de las Nieves Granada, Spain, 18012 Hospital Universitari Bellvitge Princeps d'Espanya L'Hospitalet de Llobregat , Barcelona, Spain, 08907 Hospital Juan Canalejo La Coruña, Spain, 15002 Clínica Ruber Madrid, Spain, 28006 Hospital General Universitario Gregorio Marañon Madrid, Spain, 28007 Fundación Jiménez Díaz Madrid, Spain, 28040 Hospital Clínico San Carlos Madrid, Spain, 28040 Hospital 12 de Octubre Madrid, Spain, 28041 Hospital Universitario La Paz Madrid, Spain, 28046 Universitaria de Navarra Pamplona, Spain, 31008 Policlínica Gipuzkoa San Sebastian, Spain, 20009 Hospital General de Catalunya Sant Cugat del Valles, Barcelona, Spain, 08195 Hospital Universitario Virgen del Rocio Sevilla, Spain, 41013 Hospital Mutua de Terrassa Terrassa, Barcelona, Spain, 08221 Hospital Universitario de la Fe Valencia, Spain, 46009 Hospital Clínico Universitario de Valencia Valencia, Spain, 46010 Hospital Gral. de Valencia Valencia, Spain, 46014 Collapse << |
NCT00237263 | Parkinson's Disease | Phase 2 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
NCT00547911 | Parkinson Disease ... more >> Multiple System Atrophy Autonomic Nervous System Diseases Collapse << | Phase 1 Phase 2 | Terminated(Study terminated du... more >>e to contamination droxidopa) Collapse << | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00547911 | - | - | Terminated(Study terminated du... more >>e to contamination droxidopa) Collapse << | - | - |
NCT00192855 | Schizophrenia | Not Applicable | Completed | - | Israel ... more >> Rambam medical center Haifa, Israel, 31096 Collapse << |
NCT00099268 | - | - | Completed | - | - |
NCT00373087 | Parkinson's Disease | Phase 4 | Completed | - | France ... more >> Centre d'Investigation Clinique, Hôpital de la Pitié-Salpétrière, Paris, France, 75013 Collapse << |
NCT00391898 | - | - | Completed | - | - |
NCT02058966 | Methamphetamine Dependence | Early Phase 1 | Completed | - | United States, Oregon ... more >> Oregon Health & Science University Portland, Oregon, United States, 97239 Collapse << |
NCT02349243 | Obesity | Phase 1 Phase 2 | Unknown | November 2015 | China, Shaanxi ... more >> Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University Recruiting Xi'an, Shaanxi, China, 710032 Contact: Kaichun Wu, MD, PhD 862984771502 kaicwu@fmmu.edu.cn Contact: Shiqi Wang, MD, PhD 862984771533 wsqfmmu@126.com Collapse << |
NCT00219284 | - | - | Completed | - | - |
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