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CAS No.: 1415-73-2

芦荟苷A Catalog No. CSN11403

Synonyms: Aloin-A;Barbaloin-A;Barbalin

Aloin A, an anthracycline from aloe plants, can be used as a chemopreventive factor with antineoplastic activity. It exhibits inhibition of phosphodiesterase and tyrosinase.

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技术信息

生物活性

描述Aloin A is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities. AL (Aloin A) inhibited tumor cell viability and induced cell apoptosis in vitro, and substantially reduced tumor volumes and weight in vivo mouse xenografts, without obviously toxicity^[3]. Aloin (Aloin A) exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, Aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity^[4]. Aloin attenuated LPS‑induced inflammation by inhibiting ROS‑mediated activation of the JAK1‑STAT1/3 signalling pathway, thereby inhibiting the nuclear translocation of STAT1/3 in RAW264.7 cells^[5]. Aloin (10, 30 mg/kg bw) was given by gavage to mice after each alcohol administration. Alcohol elevated the serum transaminases alanine aminotransferase, aspartate aminotransferase, total cholesterol and triglyceride levels which were significantly attenuated by the co-administration of Aloin^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3901 mL
- 11.9505 mL
- 23.9009 mL
- 5 mM
- 0.4780 mL
- 2.3901 mL
- 4.7802 mL
- 10 mM
- 0.2390 mL
- 1.1950 mL
- 2.3901 mL

技术信息

CAS号

1415-73-2

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22O9

运输

蓝冰

分子量

418.39

别名

Aloin-A;Barbaloin-A;Barbalin;Barbaloin;芦荟素;芦荟苷

溶解度

DMSO	82.0 mg/mL (196.0 mM)
Water	81.0 mg/mL (193.6 mM)
Ethanol	2.0 mg/mL (4.8 mM)

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