CAS No.: 1038915-60-4
尼拉帕尼 Catalog No. CSN13146
Synonyms: MK-4827;Zejula;尼拉帕尼
MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 PARP1
IC50:3.8nMPARP2
IC50:2.1nM- 描述
- 作用机制
- 细胞研究
- Cell Data
- 更多
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03705156 Platinum-sensitive Relapsed Ov... more >>arian Cancer Collapse << Phase 3 Recruiting June 8, 2020 - NCT03709316 Ovarian Cancer Phase 3 Recruiting June 30, 2021 - NCT03574779 Ovarian Cancer Phase 2 Recruiting June 2020 United States, Massachusetts ... more >> Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 United States, Oklahoma Stephenson Cancer Center Recruiting Oklahoma City, Oklahoma, United States, 73104 Collapse << - 更多
- 参考文献
- [1] Jones P, Altamura S, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl] phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.
- [2] Wang L, Mason KA, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20.
- [3] Javle M, Curtin NJ, et al. The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. Ther Adv Med Oncol. 2011 Nov;3(6):257-67.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1038915-60-4 | 储存条件 |
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| 分子式 | C19H20N4O | 运输 | 蓝冰 | |||||||||||||
| 分子量 | 320.39 | 别名 | MK-4827;Zejula;尼拉帕尼 | |||||||||||||
| 溶解度 |
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动物实验配方 |
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| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| A2780 cells | - | Function assay | - | Inhibition of PARP in human A2780 cells assessed as inhibition of hydrogen peroxide-induced PARylation by cell-based assay | 25761096 |
| A549 cells | - | Cytotoxicity assay | 5-7 days | Cytotoxicity against human A549 cells transfected with BRCA2 shRNA assessed as inhibition of cell proliferation after 5 to 7 days by CellTiter-Blue assay, CC50=0.011 μM | 25761096 |
| BT20 cells | - | Cytotoxicity assay | 5-7 days | Cytotoxicity against human BT20 cells assessed as inhibition of cell proliferation after 5 to 7 days by CellTiter-Blue assay, CC50=2.2 μM | 25761096 |
| Capan1 cells | - | Cytotoxicity assay | - | Cytotoxicity against BRCA2-deficient human Capan1 cells, CC50=0.09 μM | 25761096 |
| DoTc2-4510 cells | - | Cytotoxicity assay | 5-7 days | Cytotoxicity against human DoTc2-4510 cells carrying BRCA2 mutant assessed as inhibition of cell proliferation after 5 to 7 days by CellTiter-Blue assay, CC50=0.023 μM | 25761096 |
| HeLa cells | - | Function assay | - | Inhibition of PARP in hydrogen peroxide-induced human HeLa cells assessed as inhibition DNA-damage-induced PARylation, EC50=0.004 μM | 19873981 |
| Jurkat cells | - | Function assay | - | Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomide, EC50=0.2 μM | 23850199 |
| MDA-MB-436 cells | - | Proliferation assay | 6 days | Antiproliferative activity against human MDA-MB-436 cells expressing BRCA1 5396 + 1G>A mutant after 6 days by cell titer-blue assay, CC50=18 nM | 19873981 |
| SUM1315MO2 cells | - | Cytotoxicity assay | 12 days | Cytotoxicity against human SUM1315MO2 cells carrying BRCA1 mutant assessed as inhibition of cell proliferation after 12 days by CellTiter-Blue assay, CC50=0.02 μM | 25761096 |
| SUM149PT cells | - | Cytotoxicity assay | 5-7 days | Cytotoxicity against human SUM149PT cells carrying BRCA1 mutant assessed as inhibition of cell proliferation after 5 to 7 days by CellTiter-Blue assay, CC50=0.024 μM | 25761096 |
| UWB1.289 cells | - | Cytotoxicity assay | 5-7 days | Cytotoxicity against human UWB1.289 cells carrying BRCA1 mutant assessed as inhibition of cell proliferation after 5 to 7 days by CellTiter-Blue assay, CC50=0.056 μM | 25761096 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT03705156 | Platinum-sensitive Relapsed Ov... more >>arian Cancer Collapse << | Phase 3 | Recruiting | June 8, 2020 | - |
| NCT03709316 | Ovarian Cancer | Phase 3 | Recruiting | June 30, 2021 | - |
| NCT03574779 | Ovarian Cancer | Phase 2 | Recruiting | June 2020 | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 United States, Oklahoma Stephenson Cancer Center Recruiting Oklahoma City, Oklahoma, United States, 73104 Collapse << |
| NCT03598270 | Recurrent Ovarian Carcinoma | Phase 3 | Not yet recruiting | November 2023 | Spain ... more >> Complejo Hospitalario Universitario de A Coruña Not yet recruiting A Coruña, Spain Contact: María Quindós, MD Principal Investigator: María Quindós, MD ICO Badalona Not yet recruiting Badalona, Spain Contact: Margarita Romeo, MD Principal Investigator: Margarita Romeo, MD H. Clínic Barcelona Not yet recruiting Barcelona, Spain Contact: Lydia Gaba, MD Principal Investigator: Lydia Gaba, MD Hospital de la Santa Creu i Sant Pau Not yet recruiting Barcelona, Spain Contact: Cristina Martin, MD Principal Investigator: Belén Ojeda, MD Hospital de la Vall d'Hebron Not yet recruiting Barcelona, Spain Contact: Ana Oaknin, MD PhD Principal Investigator: Ana Oaknin, MD PhD H Reina Sofía Cordoba Not yet recruiting Cordoba, Spain Contact: Maria Jesus Rubio, MD Principal Investigator: Maria Jesus Rubio, MD ICO Girona Not yet recruiting Girona, Spain Contact: Pilar Barretina, MD Principal Investigator: Pilar Barretina, MD ICO Hospitalet Not yet recruiting Hospitalet del Llobregat, Spain Contact: Beatriz Pardo, MD Principal Investigator: Beatriz Pardo, MD Hospital de León Not yet recruiting León, Spain Contact: Luis Miguel de Sande, MD Principal Investigator: Luis Miguel de Sande, MD Clinica Universitaria de Navarra Not yet recruiting Madrid, Spain Contact: Antonio Gonzalez, MD PhD Principal Investigator: Antonio González, MD PhD Hospital Clínico San Carlos Not yet recruiting Madrid, Spain Contact: Gloria Marquina, MD Principal Investigator: Gloria Marquina, MD Hospital Gregorio Marañon Not yet recruiting Madrid, Spain Contact: Sara Pérez Ramírez, MD Principal Investigator: Sara Pérez Ramírez, MD Hospital Universitario La Paz Not yet recruiting Madrid, Spain Contact: Andrés Redondo, MD Principal Investigator: Andrés Redondo, MD Hospital Universitario Ramon y Cajal Not yet recruiting Madrid, Spain Contact: Eva Guerra, MD Principal Investigator: Eva Guerra, MD H Morales Meseguer Not yet recruiting Murcia, Spain Contact: Helena Garcia, Md Principal Investigator: Helena García, MD Complejo Hospitalario Regional de Málaga Not yet recruiting Málaga, Spain Contact: Maria Jose´ Bermejo, MD Principal Investigator: Maria José Bermejo, MD Hospital Son Llatzer Not yet recruiting Palma De Mallorca, Spain Contact: María Iglesias González, MD Principal Investigator: María Iglesias González, MD Hospital Virgen del Rocio Not yet recruiting Sevilla, Spain Contact: Puri Estévez, MD Principal Investigator: Puri Estévez, MD H La Fe de Valencia Not yet recruiting Valencia, Spain Contact: Ana Santaballa, MD Principal Investigator: Ana Santaballa, MD Hospital Clínico Universitario de Valencia Not yet recruiting Valencia, Spain Contact: José A Pérez Fidalgo, MD Principal Investigator: José A Pérez Fidalgo, MD Collapse << |
| NCT02044120 | Ewing Sarcoma | Phase 1 | Active, not recruiting | April 2021 | United States, California ... more >> Children's Hospital of Los Angeles Los Angeles, California, United States, 90027 United States, Maryland National Cancer Institute Bethesda, Maryland, United States, 20892 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48106 United States, Washington Seattle's Children Cancer Center Seattle, Washington, United States, 98101 United Kingdom University College London Hospital London, United Kingdom, W1T 7HA Collapse << |
| NCT03025867 | - | - | - | - | - |
| NCT03307785 | Metastatic Cancer ... more >> Advanced Cancer Solid Tumor Non Small Cell Lung Cancer Metastatic Non Small Cell Lung Cancer Stage IIIB Non Small Cell Lung Cancer Collapse << | Phase 1 | Recruiting | March 2020 | United States, Arizona ... more >> Honor Health Recruiting Scottsdale, Arizona, United States, 85258 Principal Investigator: Jasgit Sachdev, MD United States, California California Cancer Associates for Research and Excellence (cCare) Recruiting Encinitas, California, United States, 92024 Principal Investigator: Alberto Bessudo, MD United States, Florida Florida Cancer Specialist Recruiting Sarasota, Florida, United States, 34232 Principal Investigator: Manish Patel, MD United States, Ohio Gabrail Cancer Center Research Recruiting Canton, Ohio, United States, 44718 Principal Investigator: Nashat Gabrail, MD United States, Tennessee Tennessee Oncology Recruiting Nashville, Tennessee, United States, 37203 Principal Investigator: Erika Hamilton, MD United States, Texas MD Anderson Recruiting Houston, Texas, United States, 77030 Principal Investigator: Timothy Yap, MD Collapse << |
| NCT03748641 | Metastatic Prostate Cancer | Phase 3 | Not yet recruiting | February 25, 2025 | - |
| NCT03651206 | Ovarian Carcinosarcoma ... more >> Endometrial Carcinosarcoma Collapse << | Phase 2 Phase 3 | Not yet recruiting | January 2023 | - |
| NCT03695380 | OVARIAN CANCER | Phase 1 | Not yet recruiting | November 24, 2022 | - |
| NCT03431350 | Prostatic Neoplasms, Castratio... more >>n-Resistant Collapse << | Phase 1 Phase 2 | Recruiting | December 31, 2020 | United States, Colorado ... more >> The Urology Center of Colorado Recruiting Denver, Colorado, United States, 80211 United States, New York Memorial Sloan Kettering Cancer Center Recruiting Harrison, New York, United States, 10604 Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 United States, Pennsylvania Thomas Jefferson University Recruiting Philadelphia, Pennsylvania, United States, 19107 United States, South Carolina MUSC-Hollings Cancer Center Recruiting Charleston, South Carolina, United States, 29425 United States, Texas The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 United States, Utah University of Utah Huntsman Cancer Institute Withdrawn Salt Lake City, Utah, United States, 84112 United States, Wisconsin University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 5379200 Canada, Quebec Centre de Recherche du CHUM Not yet recruiting Montreal, Quebec, Canada, H2X 0A9 Canada British Columbia Cancer Agency Recruiting Vancouver, Canada, V5Z4E6 Israel Asaf Harofe Medical Center Recruiting Beer Yaakov, Israel, 60930 Rambam Medical Center Recruiting Haifa, Israel, 31096 Rabin Medical Center Recruiting Petach Tikva, Israel, 49100 Sheba Medical Center Tel Hashomer Recruiting Ramat Gan, Israel, 52621 Spain Hospital Vall D'Hebron Recruiting Barcelona, Spain, 08035 Hosp. Univ. Fund. Jimenez Diaz Recruiting Madrid, Spain, 28040 Hosp. Univ. Hm Sanchinarro Recruiting Madrid, Spain, 28050 United Kingdom Guy's Hospital Withdrawn London, United Kingdom, SE1 9RT Southampton General Hospital Not yet recruiting Southampton, United Kingdom, SO16 6YD The Royal Marsden NHS Trust Sutton Recruiting Sutton, United Kingdom, SM2 5PT Collapse << |
| NCT03516084 | Extensive-stage Small Cell Lun... more >>g Cancer Collapse << | Phase 3 | Not yet recruiting | May 2022 | - |
| NCT03551171 | Ovarian Cancer | Phase 1 | Active, not recruiting | December 30, 2018 | China, Beijing ... more >> Beijing Cancer Hospital Beijing, Beijing, China, 100000 China, Guangdong Sun Yat-sen University Cancer Center Guangzhou, Guangdong, China, 510000 China, Heilongjiang Haerbin Medical University Cancer Hospital Harbin, Heilongjiang, China, 150000 China, Hunan Hunan Cancer Hospital Changsha, Hunan, China, 410013 China, Shanghai Fudan University Shanghai Cnacer Center Shanghai, Shanghai, China, 200000 China, Sichuan The West China Second UniversityHospital of Sichuan University Chengdu, Sichuan, China, 610000 Collapse << |
| NCT03404960 | Pancreatic Adenocarcinoma | Phase 1 Phase 2 | Recruiting | June 2021 | United States, Pennsylvania ... more >> University of Pennsylvania, Abramson Cancer Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Danielle Karlson 215-220-9704 danielle.Karlson@uphs.upenn.edu Principal Investigator: Kim Reiss Binder, MD Collapse << |
| NCT03602859 | Ovarian Cancer | Phase 3 | Recruiting | July 31, 2023 | United States, Alaska ... more >> Alaska Women's Cancer Care Recruiting Anchorage, Alaska, United States, 99508 United States, Connecticut Hartford Hospital Recruiting Hartford, Connecticut, United States, 06102 United States, Louisiana Women's Cancer Care Recruiting Covington, Louisiana, United States, 70433 Willis-Knighton Cancer Center Recruiting Shreveport, Louisiana, United States, 71103 United States, Maryland Holy Cross Hospital Recruiting Silver Spring, Maryland, United States, 20910 United States, Ohio Aultman Hospital Recruiting Canton, Ohio, United States, 44710 United States, South Dakota Avera Cancer Institute Recruiting Sioux Falls, South Dakota, United States, 57105 United States, Washington Kadlec Regional Medical Center Recruiting Kennewick, Washington, United States, 99336 Swedish Medical Center Recruiting Seattle, Washington, United States, 98104 Collapse << |
| NCT02476552 | Cancer | Phase 1 | Completed | - | Netherlands ... more >> The Netherlands Cancer Institute Amsterdam, Netherlands, 1066 CX Collapse << |
| NCT02655016 | Ovarian Cancer | Phase 3 | Active, not recruiting | - | - |
| NCT02354131 | Ovarian Cancer | Phase 1 Phase 2 | Active, not recruiting | December 2020 | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States Denmark Rigshospitalet Copenhagen, Sjaelland, Denmark, 2100 Collapse << |
| NCT02354586 | Ovarian Cancer | Phase 2 | Active, not recruiting | December 2019 | - |
| NCT02657889 | Triple Negative Breast Cancer ... more >> Ovarian Cancer Breast Cancer Metastatic Breast Cancer Advanced Breast Cancer Stage IV Breast Cancer Fallopian Tube Cancer Peritoneal Cancer Collapse << | Phase 1 Phase 2 | Active, not recruiting | February 2019 | - |
| NCT03326193 | Ovarian Cancer ... more >> Fallopian Tube Cancer Primary Peritoneal Carcinoma Collapse << | Phase 2 | Recruiting | September 30, 2021 | - |
| NCT02826512 | Breast Cancer | Phase 2 | Recruiting | August 2022 | Netherlands ... more >> Antoni van Leeuwenhoek Recruiting Amsterdam, Netherlands, 1066 CX Contact: Sabine C Linn, MD +3120512 ext 2951 s.linn@nki.nl Contact: Sonja Vliek, MD s.vliek@nki.nl Principal Investigator: Sabine C Linn, MD Erasmus Medical Center Cancer Institute Not yet recruiting Rotterdam, Netherlands, 3015CE Contact: A Jager, MD a.jager@erasmusmc.nl Principal Investigator: A Jager, MD Collapse << |
| NCT02924766 | Prostatic Neoplasms | Phase 1 | Active, not recruiting | March 7, 2019 | United States, California ... more >> West Hollywood, California, United States United States, Kentucky Louisville, Kentucky, United States United States, Oregon Portland, Oregon, United States United States, South Carolina Myrtle Beach, South Carolina, United States Canada, British Columbia Vancouver, British Columbia, Canada Canada, Quebec Montreal, Quebec, Canada Collapse << |
| NCT03308942 | Lung Neoplasms | Phase 2 | Recruiting | May 2020 | - |
| NCT02854436 | Prostatic Neoplasms | Phase 2 | Recruiting | June 2021 | - |
| NCT03553004 | Pancreatic Cancer | Phase 2 | Not yet recruiting | February 1, 2025 | United States, Kansas ... more >> University of Kansas Cancer Center - Clinical Research Center Not yet recruiting Fairway, Kansas, United States, 66208 Contact: kerry hepler 913-945-7552 ctnursenav@kumc.edu University of Kansas Cancer Center - West Not yet recruiting Kansas City, Kansas, United States, 66112 Contact: Kerry Hepler 913-945-7552 ctnursenav@kumc.edu University of Kansas Cancer Center - Overland Park Not yet recruiting Overland Park, Kansas, United States, 66210 Contact: kerry hepler 913-945-7552 ctnursenav@kumc.edu The University of Kansas Cancer Center Not yet recruiting Westwood, Kansas, United States, 66205 Contact: Kerry Hepler, RN 913-945-7552 ctnursenav@kumc.edu Principal Investigator: Anup Kasi, MD United States, Missouri University of Kansas Cancer Center - North Not yet recruiting Kansas City, Missouri, United States, 64154 Contact: kerr hepler 913-945-7552 ctnursenav@kumc.edu Principal Investigator: Anup Kasi, MD University of Kansas Cancer Center - Lee's Summit Not yet recruiting Lee's Summit, Missouri, United States, 64064 Contact: Kerry Hepler 913-945-7552 ctnursenav@kumc.edu Collapse << |
| NCT03207347 | Mesothelioma ... more >>Uveal Melanoma Renal Cell Carcinoma Cholangiocarcinoma Collapse << | Phase 2 | Recruiting | December 2022 | United States, Florida ... more >> University of Florida Recruiting Gainesville, Florida, United States, 32610 Principal Investigator: Thomas George, MD, FACP Collapse << |
| NCT02500901 | Metastatic Prostate Cancer | Phase 1 | Terminated(Suspended by funder... more >>) Collapse << | - | United States, Massachusetts ... more >> Tufts Medical Center Boston, Massachusetts, United States, 02111 Collapse << |
| NCT03759600 | Ovarian Cancer ... more >> Fallopian Tube Cancer Primary Peritoneal Cancer Collapse << | Phase 2 | Not yet recruiting | November 30, 2020 | Japan ... more >> Aichi Cancer Center Hospital Not yet recruiting Nagoya, Aichi, Japan Hirosaki University Hospital Not yet recruiting Hirosaki, Aomori, Japan National Cancer Center Hospital East Not yet recruiting Kashiwa, Chiba, Japan The Jikei University Kashiwa Hospital Not yet recruiting Kashiwa, Chiba, Japan Shikoku Cancer Center Not yet recruiting Matsuyama, Ehime, Japan Ehime University Hospital Not yet recruiting Toon, Ehime, Japan Kurume University Hospital Not yet recruiting Kurume, Fukuoka, Japan Hokkaido University Hospital Not yet recruiting Sapporo, Hokkaido, Japan Sapporo Medical University Hospital Not yet recruiting Sapporo, Hokkaido, Japan Hyogo Cancer Center Not yet recruiting Akashi, Hyogo, Japan Kansai Rosai Hospital Not yet recruiting Amagasaki, Hyogo, Japan Iwate Medical University Hospital Not yet recruiting Morioka, Iwate, Japan Tokai University Hospital Not yet recruiting Isehara, Kanagawa, Japan Nippon Medical School Musashi Kosugi Hospital Not yet recruiting Kawasaki, Kanagawa, Japan Mie University Hospital Not yet recruiting Tsu, Mie, Japan Tohoku University Hospital Not yet recruiting Sendai, Miyagi, Japan University of the Ryukyus Hospital Not yet recruiting Nakagami-gun, Okinawa, Japan Kindai University Hospital Not yet recruiting Osakasayama, Osaka, Japan Saitama Medical University International Medical Center Not yet recruiting Hidaka, Saitama, Japan Shizuoka Cancer Center Not yet recruiting Nagaizumi-cho, Shizuoka, Japan National Cancer Center Hospital Not yet recruiting Chuo-ku, Tokyo, Japan Cancer Institute Hospital Not yet recruiting Koto-ku, Tokyo, Japan The Jikei University Hospital Not yet recruiting Minato-ku, Tokyo, Japan Toho University Omori Medical Center Not yet recruiting Ota-ku, Tokyo, Japan Keio University Hospital Not yet recruiting Shinjuku-ku, Tokyo, Japan Chiba Cancer Center Not yet recruiting Chiba, Japan Gifu University Hospital Not yet recruiting Gifu, Japan Kagoshima City Hospital Not yet recruiting Kagoshima, Japan Kyoto University Hospital Not yet recruiting Kyoto, Japan Nagasaki University Hospital Not yet recruiting Nagasaki, Japan Niigata University Medical & Dental Hospital Not yet recruiting Niigata, Japan Collapse << |
| NCT03497429 | Advanced Solid Tumors | Phase 1 | Active, not recruiting | August 31, 2019 | Japan ... more >> National Cancer Center Hospital Chuo-ku, Tokyo, Japan Collapse << |
| NCT03359850 | Solid Tumor H... more >>epatic Impairment Collapse << | Phase 1 | Recruiting | February 2019 | United States, California ... more >> University of Southern California Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90089 Principal Investigator: Anthony El-Khoueiry, MD United States, Colorado University of Colorado Anschutz Medical Campus Recruiting Aurora, Colorado, United States, 80045 Principal Investigator: Cindy O' Bryant, MD United States, Georgia Winship Cancer Institute of Emory University Recruiting Atlanta, Georgia, United States, 30322 Principal Investigator: Akce Mehmet United States, Texas MD Anderson Recruiting Houston, Texas, United States, 77030 Principal Investigator: Sirena Piha-Paul, MD Collapse << |
| NCT01110603 | Cancer: Solid Tumors | Phase 1 | Terminated | - | - |
| NCT01847274 | Platinum Sensitive Ovarian Can... more >>cer Collapse << | Phase 3 | Completed | - | - |
| NCT03586661 | Deleterious BRCA1 Gene Mutatio... more >>n Deleterious BRCA2 Gene Mutation Endometrial Adenocarcinoma High Grade Ovarian Serous Adenocarcinoma Primary Peritoneal High Grade Serous Adenocarcinoma Recurrent Endometrial Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Collapse << | Phase 1 | Not yet recruiting | October 2020 | United States, Texas ... more >> M D Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Contact: N. swestin@mdanderson.org Collapse << |
| NCT03016338 | Endometrial Cancer | Phase 2 | Recruiting | September 2022 | Canada, Alberta ... more >> Tom Baker Cancer Centre Recruiting Calgary, Alberta, Canada, T2N 4N2 Contact: Prafull Ghatage, M.D. 403-521-3721 Principal Investigator: Prafull Ghatage Canada, Ontario Juravinski Cancer Centre Recruiting Hamilton, Ontario, Canada, L8V 5C2 Contact: Waldo Jimenez, M.D. 905-387-9495 Principal Investigator: Waldo Jimenez, M.D. Cancer Centre of Southeastern Ontario at Kingston Recruiting Kingston, Ontario, Canada, K7L 5P9 Contact: Jim Biagi, M.D. 613-44-2630 Principal Investigator: Jim Biagi, M.D. London Regional Cancer Centre Recruiting London, Ontario, Canada, N6A 4L6 Contact: Stephen Welch, M.D. 519-685-8640 Sunnybrook Research Institute, Sunnybrook Health Sciences Centre Recruiting Toronto, Ontario, Canada, M4N 3M5 Contact: Helen MacKay, M.D. 416-480-5145 Principal Investigator: Helen MacKay, M.D. Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada, M5G 1M9 Contact: Stephanie Lheureux, M.D. 416-946-2818 Principal Investigator: Stephanie Lheureux, M.D. Canada, Quebec McGill University Health Centre - Glen Site Recruiting Montréal, Quebec, Canada, H3A 3J1 Contact: Lucy Gilbert, M.D. 514-934-1934 ext 34049 Principal Investigator: Lucy Gilbert, M.D. Collapse << |
| NCT03154281 | Breast Cancer ... more >> Ovarian Cancer Collapse << | Phase 1 | Recruiting | June 2021 | United States, South Dakota ... more >> Avera Cancer Institute Recruiting Sioux Falls, South Dakota, United States, 57105 Contact: Brian Leyland-Jones, MD 605-322-6900 brian.leylandjones@avera.org Collapse << |
| NCT03329001 | Solid Tumor | Phase 1 | Recruiting | December 2019 | United States, California ... more >> California Cancer Center for Research Excellence cCARE Recruiting Encinitas, California, United States, 92024 Principal Investigator: Alberto Bessudo, MD United States, Georgia Winship Cancer Institute of Emory University Recruiting Atlanta, Georgia, United States, 30322 Principal Investigator: R. Donald Harvey, PharmD United States, Tennessee Tennesse Oncology (SCRI) Recruiting Nashville, Tennessee, United States, 37203 Principal Investigator: Erika Hamilton, MD United States, Texas MD Anderson Recruiting Houston, Texas, United States, 77030 Principal Investigator: Sarina Piha-Paul, MD START- South Texas Accelerated Research Therapeutics, LLC Recruiting San Antonio, Texas, United States, 78229 Principal Investigator: Amita Patnaik, MD Collapse << |
| NCT01905592 | Carcinoma of Breast ... more >> Human Epidermal Growth Factor 2 Negative Carcinoma of Breast BRCA1 Gene Mutation BRCA2 Gene Mutation Collapse << | Phase 3 | Active, not recruiting | May 2018 | - |
| NCT03425201 | Urothelial Cancer | Phase 1 Phase 2 | Not yet recruiting | December 2019 | Spain ... more >> ICO Badalona Badalona, Spain Hospital Clinic Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain ICO L'Hospitalet L'Hospitalet De Llobregat, Spain ICO L'Hospitalet Not yet recruiting L'Hospitalet De Llobregat, Spain Contact: Nuria Sala Hospital 12 de Octubre Madrid, Spain Althaia Xarxa Not yet recruiting Manresa, Spain Contact: Montserrat Domenech Instituto Valenciano de Oncología Valencia, Spain Collapse << |
| NCT03759587 | Ovarian Cancer ... more >> Fallopian Tube Cancer Primary Peritoneal Cancer Collapse << | Phase 2 | Not yet recruiting | April 30, 2021 | Japan ... more >> Aichi Cancer Center Hospital Not yet recruiting Nagoya, Aichi, Japan Hirosaki University Hospital Not yet recruiting Hirosaki, Aomori, Japan Shikoku Cancer Center Not yet recruiting Matsuyama, Ehime, Japan Ehime University Hospital Not yet recruiting Toon, Ehime, Japan Kurume University Hospital Not yet recruiting Kurume, Fukuoka, Japan Hokkaido University Hospital Not yet recruiting Sapporo, Hokkaido, Japan Sapporo Medical University Hospital Not yet recruiting Sapporo, Hokkaido, Japan Hyogo Cancer Center Not yet recruiting Akashi, Hyogo, Japan Kansai Rosai Hospital Not yet recruiting Amagasaki, Hyogo, Japan Iwate Medical University Hospital Not yet recruiting Morioka, Iwate, Japan Tokai University Hospital Not yet recruiting Isehara, Kanagawa, Japan Nippon Medical School Musashi Kosugi Hospital Not yet recruiting Kawasaki, Kanagawa, Japan Mie University Hospital Not yet recruiting Tsu, Mie, Japan Tohoku University Hospital Not yet recruiting Sendai, Miyagi, Japan University of the Ryukyus Hospital Not yet recruiting Nakagami-gun, Okinawa, Japan Kindai University Hospital Not yet recruiting Osakasayama, Osaka, Japan Saitama Medical University International Medical Center Not yet recruiting Hidaka, Saitama, Japan Shizuoka Cancer Center Not yet recruiting Nagaizumi-cho, Shizuoka, Japan National Cancer Center Hospital Not yet recruiting Chuo-ku, Tokyo, Japan Cancer Institute Hospital Not yet recruiting Koto-ku, Tokyo, Japan The Jikei University Hospital Not yet recruiting Minato-ku, Tokyo, Japan Keio University Hospital Not yet recruiting Shinjuku-ku, Tokyo, Japan Chiba Cancer Center Not yet recruiting Chiba, Japan Kagoshima City Hospital Not yet recruiting Kagoshima, Japan Kyoto University Hospital Not yet recruiting Kyoto, Japan Nagasaki University Hospital Not yet recruiting Nagasaki, Japan Niigata University Medical & Dental Hospital Not yet recruiting Niigata, Japan Collapse << |
| NCT03076203 | Prostate Carcinoma Metastatic ... more >>to the Bone Stage IV Prostate Adenocarcinoma Hormone-refractory Prostate Cancer Collapse << | Phase 1 | Recruiting | November 2021 | United States, Pennsylvania ... more >> Sidney Kimmel Cancer Center at Thomas Jefferson University Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: William Kelly, DO william.kelly@jefferson.edu Collapse << |
| NCT03209401 | Solid Tumor, Adult ... more >> Homologous Recombination Deficiency Collapse << | Phase 1 | Recruiting | July 2022 | United States, District of Col... more >>umbia Lombardi Comprehensive Cancer Center Recruiting Washington, District of Columbia, United States, 20057 Contact: Laura Macke, RN 202-687-2111 lab228@georgetown.edu Principal Investigator: Michael Pishvaian, MD, PhD Principal Investigator: Claudine Isaacs, MD Collapse << |
| NCT03601923 | Pancreatic Cancer | Phase 2 | Recruiting | February 28, 2025 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: James Cleary, MD, PhD 617-632-6353 JCLEARY@PARTNERS.ORG Principal Investigator: James Cleary, MD, PhD Collapse << |
| NCT03752216 | Ovarian Cancer | Phase 4 | Not yet recruiting | November 2021 | France ... more >> Institut Sainte-Catherine Not yet recruiting Avignon, France, 84918 Contact: Julien GRENIER CHRU Jean Minjoz Not yet recruiting Besançon, France, 25030 Contact: Elsa KALBACHER Clinique Tivoli Not yet recruiting Bordeaux, France, 33000 Contact: Delphine GARBAY-DECOOPMAN Institut Bergonié Not yet recruiting Bordeaux, France, 33076 Contact: Camille CHAKIBA Hôpital Fleyriat Not yet recruiting Bourg-en-bresse, France, 01012 Contact: Hubert ORFEUVRE Centre François Baclesse Not yet recruiting Caen, France, 14000 Contact: Pierre-Emmanuel BRACHET ROC 37 Société de Recherche Oncologique Clinique 37 Not yet recruiting Chambray-lès-Tours, France, 37170 Contact: Pierre COMBE Centre Jean Perrin Not yet recruiting Clermont-Ferrand, France, 63000 Contact: Marie Ange MOURET-REYNIER Centre Léon Bérard Not yet recruiting Lyon, France, 69373 Contact: Isabelle RAY-COQUARD Hôpital Privé Jean Mermoz Not yet recruiting Lyon, France, 69373 Contact: Olfa DERBEL Institut Paoli Calmettes Not yet recruiting Marseille, France, 13009 Contact: Magali PROVANSAL CH Mont-de-Marsan Not yet recruiting Mont-de-marsan, France, 40024 Contact: Jérôme DAUBA ICM Val d'Aurelle Not yet recruiting Montpellier, France, 34298 Contact: Michel FABBRO ORACLE - Centre d'Oncologie de Gentilly Not yet recruiting Nancy, France, 54100 Contact: Célia ROEMER-BECUWE Centre Antoine Lacassagne Not yet recruiting Nice, France, 06189 Contact: Philippe FOLLANA Centre ONCOGARD - Institut de Cancérologie du Gard Not yet recruiting Nimes, France, 30029 Contact: Eric LEGOUFFE Hôpital Cochin Not yet recruiting Paris, France, 75014 Contact: Jérôme ALEXANDRE Groupe Hospitalier Diaconesses-Croix Saint Simon Not yet recruiting Paris, France, 75020 Contact: Frédéric SELLE Centre CARIO - HPCA Not yet recruiting Plérin, France, 22190 Contact: Anne-Claire HARDY-BESSARD Clinique Mutualiste de l'Estuaire Not yet recruiting Saint-nazaire, France, 44600 Contact: Valérie DELECROIX Institut de Cancérologie Lucien Neuwirth Not yet recruiting Saint-Priest-en-Jarez, France, 42271 Contact: Olivier COLLARD Hôpitaux Universitaires de Strasbourg Not yet recruiting Strasbourg, France, 67000 Contact: Jean-Emmanuel KURTZ Institut Claudius Regaud Not yet recruiting Toulouse, France, 31059 Contact: Laurence GLADIEFF Clinique Pasteur - ONCOSUD Not yet recruiting Toulouse, France, 31076 Contact: Raymond DESPAX Gustave Roussy Not yet recruiting Villejuif, France, 94805 Contact: Fanny POMMERET Collapse << |
| NCT03644342 | Metastatic Carcinoma of the Ce... more >>rvix Collapse << | Phase 1 Phase 2 | Not yet recruiting | March 2, 2026 | United States, Texas ... more >> Baylor College of Medicine Not yet recruiting Houston, Texas, United States, 77030 Contact: Michelle S Ludwig, MD, MPH, PhD 713-566-3757 Michelle.Ludwig@bcm.edu Harris Health System - Smith Clinic Houston, Texas, United States, 77054 Collapse << |
| NCT01294735 | Recurrence of Solid Tumor ... more >> Glioblastoma Multiforme Melanoma Collapse << | Phase 1 | Completed | - | - |
| NCT03368729 | Metastatic Breast Cancer ... more >> HER2 Positive Breast Carcinoma Collapse << | Phase 1 Phase 2 | Not yet recruiting | November 1, 2021 | United States, Alabama ... more >> University of Alabama at Birmingham Not yet recruiting Birmingham, Alabama, United States, 35294 Contact: Erica Stringer-Reasor, M.D. 205-934-2992 strinem@uab.edu Collapse << |
| NCT01227941 | Ovarian Cancer | Phase 1 | Terminated | - | - |
| NCT03329937 | Human Epidermal Growth Factor ... more >>2 Negative Carcinoma of Breast BRCA1 Gene Mutation BRCA2 Gene Mutation Collapse << | Phase 1 | Recruiting | March 2020 | United States, California ... more >> Pacific Shores Medical Oncology Recruiting Long Beach, California, United States, 90808 United States, Florida Florida Cancer Specialists- South Recruiting Fort Myers, Florida, United States, 33901 Memorial Health Care System Recruiting Pembroke, Florida, United States, 33028 Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at John Hopkins Recruiting Baltimore, Maryland, United States, 21231 United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 United States, Oregon Providence Portland Medical center Recruiting Portland, Oregon, United States, 97231 United States, Tennessee Tennessee Oncology Recruiting Nashville, Tennessee, United States, 37203 United States, Texas Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Collapse << |
| NCT00749502 | Solid Tumors ... more >>Chronic Lymphocytic Leukemia T-cell-prolymphocytic Leukemia Collapse << | Phase 1 | Completed | - | - |
| NCT01244009 | Lymphoma Mant... more >>le-Cell Collapse << | Phase 2 | Withdrawn(Sponsor decision) | August 2013 | - |
| NCT01226901 | Neoplasms Sol... more >>id Tumors Collapse << | Phase 1 | Terminated | - | - |
| 靶点 | Description | IC50 |
|---|---|---|
| PARP1 | IC50:3.8nM | |
| PARP2 | IC50:2.1nM |
