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CAS No.: 1642288-47-8
Synonyms: MYK461;SAR439152
MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03442764 | Non-obstructive Hypertrophic C... more >>ardiomyopathy Collapse << | Phase 2 | Recruiting | July 2019 | - |
NCT03723655 | Hypertrophic Cardiomyopathy | Phase 2 Phase 3 | Enrolling by invitation | June 2022 | United States, Oregon ... more >> Oregon Health & Sciences University Portland, Oregon, United States, 97239 Collapse << |
NCT03470545 | Obstructive Hypertrophic Cardi... more >>omyopathy Collapse << | Phase 3 | Recruiting | June 2020 | - |
实验方案
技术信息
CAS号 | 1642288-47-8 | 储存条件 |
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分子式 | C15H19N3O2 | 运输 | 蓝冰 | |
分子量 | 273.33 | 别名 | MYK461;SAR439152 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03442764 | Non-obstructive Hypertrophic C... more >>ardiomyopathy Collapse << | Phase 2 | Recruiting | July 2019 | - |
NCT03723655 | Hypertrophic Cardiomyopathy | Phase 2 Phase 3 | Enrolling by invitation | June 2022 | United States, Oregon ... more >> Oregon Health & Sciences University Portland, Oregon, United States, 97239 Collapse << |
NCT03470545 | Obstructive Hypertrophic Cardi... more >>omyopathy Collapse << | Phase 3 | Recruiting | June 2020 | - |
NCT02329184 | Hypertrophic Cardiomyopathy | Phase 1 | Completed | - | United States, Arizona ... more >> Scottsdale, Arizona, United States, 85259 United States, California Cypress, California, United States, 90630 Stanford, California, United States, 94305 United States, Massachusetts Boston, Massachusetts, United States, 02111 United States, Michigan Kalamazoo, Michigan, United States, 49007 United States, North Carolina Durham, North Carolina, United States, 27710 United States, Tennessee Nashville, Tennessee, United States, 37232 Collapse << |
NCT03496168 | Hypertrophic Cardiomyopathy | Phase 2 | Recruiting | June 2020 | United States, Arizona ... more >> Mayo Clinic Arizona, Mayo Clinic Scottsdale Recruiting Scottsdale, Arizona, United States, 85259 Principal Investigator: Steven Heitner, MD United States, Connecticut Yale New Haven Hospital Recruiting New Haven, Connecticut, United States, 06511 Principal Investigator: Daniel Jacoby, MD United States, North Carolina Duke Cardiology at Southpoint Recruiting Durham, North Carolina, United States, 27713 Principal Investigator: Andrew Wang, MD United States, Oregon Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239 Principal Investigator: Stephen Heitner, MD Collapse << |
NCT02356289 | Healthy | Phase 1 | Completed | - | United Kingdom ... more >> Quintles LTD London, United Kingdom Collapse << |
NCT02480296 | Healthy | Phase 1 | Completed | - | Australia, Victoria ... more >> Nucleus Network Melbourne, Victoria, Australia Collapse << |
NCT02842242 | Cardiomyopathy, Hypertrophic O... more >>bstructive Collapse << | Phase 2 | Completed | - | United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States United States, Connecticut Yale New Haven Hospital New Haven, Connecticut, United States United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States United States, Missouri Washington University St. Louis Saint Louis, Missouri, United States United States, North Carolina Duke Health Center at Southpoint Durham, North Carolina, United States United States, Oregon Oregon Health and Science University Portland, Oregon, United States United States, Pennsylvania Hospital of the University of Pennsylvania (Penn Heart and Vascular Center) Philadelphia, Pennsylvania, United States Collapse << |
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