|(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-乙酰氧基-9-(((2R,3S)-3-苯甲酰胺-2-羟基-3-苯基丙酰基)氧基)-4,6,11-三羟基-4a,8,13,13-四甲基-5-氧代-2a,3,4,4a,5,6,9,10,11,12,12a,12b-十二氢-1H-7,11-甲桥环癸[3,4]苯并[1,2-b]氧杂环丁烷-12-基苯甲酸酯|CsnPharm

CAS No.: 78432-77-6

10-Deacetyltaxol/10-去乙酰紫杉醇 Catalog No. CSN19484

Synonyms: 10-Deacetylpaclitaxel;10-DAT;Deacetyl Paclitaxel

Deacetyltaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. with cytotoxicity in human glial and neuroblastoma cell-lines.

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技术信息

生物活性

描述Deacetyltaxol (10-Deacetyltaxol) is a taxane derivative isolated from Taxus wallichiana Zucc^[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines^[3]. The wood of Taxus yunnanensis (Taxaceae) showed growth inhibitory activities against human cancer cell lines, such as cervical HeLa adenocarcinoma. Taxane-type diterpenes, such as 10-deacetylcephalomannine and 10-deacetyltaxol, were found to be present in amounts consistent with the growth inhibitory activity^[4].
参考文献

[1] Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.
[2] McLaughlin JL, Miller RW, Powell RG, Smith CR Jr. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9
[3] Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9
[4] Ueda JY, Awale S, Tezuka Y, Shimamura E, Hirai K, Nobukawa T, Sato A, Kadota S. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2317 mL
- 6.1586 mL
- 12.3173 mL
- 5 mM
- 0.2463 mL
- 1.2317 mL
- 2.4635 mL
- 10 mM
- 0.1232 mL
- 0.6159 mL
- 1.2317 mL

技术信息

CAS号

78432-77-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C45H49NO13

运输

蓝冰

分子量

811.87

别名

10-Deacetylpaclitaxel;10-DAT;Deacetyl Paclitaxel;10-DAP;10-去乙酰紫杉醇;7-表-10-去乙酰基紫杉醇

溶解度

DMSO	220.0 mg/mL (271.0 mM)
Water	insoluble

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10-Deacetyltaxol/10-去乙酰紫杉醇 Catalog No. CSN19484

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