|1,2-双(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸|CsnPharm

CAS No.: 85233-19-8

1,2-双(2-氨基苯氧基)乙烷-N,N,N′,N′-四乙酸 Catalog No. CSN10376

Synonyms: BAPTA

BAPTA is an chelator of Ca2+ that can suppress intracellular reactive oxygen species (ROS). BAPTA is used as a neuroprotective agent.

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技术信息

生物活性

描述BAPTA is a non-permeable, selective extracellular calcium chelator, with 105-fold greater affinity for Ca2+ than Mg2+. Basal [3H]-noradrenaline release was reduced by BAPTA/AM in a concentration-dependent manner (50% at 30 microM), but reduction of external Ca2+ from 1.3 to 0.5 mM did not alter basal release^[3]. Pretreatment of PBMCs with KH7 (a specific peptide inhibitor of soluble AC) and the calcium inhibitor (Bapta) prior to LA (Lipoic acid) treatment resulted in reduced cAMP levels, suggesting that soluble AC (adenylyl cyclases) and calcium signaling mediate LA stimulation of cAMP production^[4]. BAPTA-AM inhibit osteoclastogenic ability of BMMs (bone marrow macrophages) via suppressing the increase of [Ca(2+)](i) which lead to inhibit RANKL-induced the phosphorylation of ERK, Akt and p38 MAPK, but not JNK^[5]. Superfusion with BAPTA-AM (50 microM) induced a rapid (< 60 s) and reversible block of both I(KCa) and I(K) (approximately 50%), without affecting either I(Ca) or I(Na). There has a fast and reversible block of I(KCa) and I(K) by BAPTA-AM, acting directly on K+ channels before it operates as a Ca2+ chelator, in cultured bovine chromaffin cells^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02025049	Pancreatitis	Phase 2	Terminated(Slow recruitment)	-	Czech Republic ... more >> The University Hospital Brno, Gastroenterology Clinic Brno, Czech Republic, 62500 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0989 mL
- 10.4946 mL
- 20.9893 mL
- 5 mM
- 0.4198 mL
- 2.0989 mL
- 4.1979 mL
- 10 mM
- 0.2099 mL
- 1.0495 mL
- 2.0989 mL

技术信息

CAS号

85233-19-8

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H24N2O10

运输

蓝冰

分子量

476.43

别名

BAPTA

溶解度

DMSO	160.0 mg/mL (335.8 mM)
Water	80.0 mg/mL (167.9 mM)

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1,2-双(2-氨基苯氧基)乙烷-N,N,N′,N′-四乙酸 Catalog No. CSN10376

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