CAS No.: 51050-59-0
3,4-Dichloroisocoumarin/3,4二氯异香豆素 Catalog No. CSN24042
Synonyms: 3,4-DCI;3,4-Dichloro-1H-isochromen-1-one
3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components in vitro. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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tech@csnpharm.cn靶点选择性
生物活性
- 描述
动物研究 剂量 Rabbit: 2 mg/kg[4] (i.v.)
给药途径 i.v.
- 参考文献
- [1] Rusbridge NM, Beynon RJ, et al. 3,4-Dichloroisocoumarin, a serine protease inhibitor, inactivates glycogen phosphorylase b. FEBS Lett. 1990 Jul 30;268(1):133-6.
- [2] Harper JW, Hemmi K, et al. Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor. Biochemistry. 1985 Apr 9;24(8):1831-41.
- [3] Pereira ME, Nguyen T, et al. 3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex. J Biol Chem. 1992 Apr 15;267(11):7949-55.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 51050-59-0 | 储存条件 |
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| 分子式 | C9H4Cl2O2 | 运输 | 蓝冰 | |||||
| 分子量 | 215.03 | 别名 | 3,4-DCI;3,4-Dichloro-1H-isochromen-1-one | |||||
| 溶解度 |
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动物实验配方 |
