|4-(3-(4-氟苯基)脲基)苯磺酰胺|CsnPharm

CAS No.: 178606-66-1

4-(3-(4-Fluorophenyl)ureido)benzenesulfonamide Catalog No. CSN16983

Synonyms: SLC-0111;MST-104;NSC-213841

U-104 is a potent carbonic anhydrase (CA) inhibitor with Ki of 45.1 nM and 4.5 nM for CA IX and CA XII, respectively.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述CAIX (Carbonic anhydrase IX) is a hypoxia and HIF-1–inducible protein that regulates intra- and extracellular pH under hypoxic conditions and promotes tumor cell survival and invasion in hypoxic microenvironments. U-104 is a novel ureido-sulfonamide inhibitor of CAIX and CAXII with Ki values of 45.1nM and 4.5nM, respectively. Administration of U-104 daily significantly inhibited primary tumor growth in the mice injected with a highly metastatic variant of the MDA-MB-231 cell line with robustly induced CAIX in hypoxia. Also, it resulted the inhibition of metastases formation of mice intravenous injected with 4T1 cells.
动物研究
剂量
Mice^[2] (p.o.): 38 mg/kg

给药途径
p.o.,
参考文献

动物研究
剂量	Mice^[2] (p.o.): 38 mg/kg
给药途径	p.o.,

[1] Lou Y, McDonald PC, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2329 mL
- 16.1647 mL
- 32.3294 mL
- 5 mM
- 0.6466 mL
- 3.2329 mL
- 6.4659 mL
- 10 mM
- 0.3233 mL
- 1.6165 mL
- 3.2329 mL

技术信息

CAS号

178606-66-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H12FN3O3S

运输

蓝冰

分子量

309.32

别名

SLC-0111;MST-104;NSC-213841

溶解度

DMSO	50.0 mg/mL (161.6 mM)
Water	insoluble

动物实验配方

30% PEG400+0.5% Tween80+5% propylene glycol+water

30 mg/mL

suspension

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4-(3-(4-Fluorophenyl)ureido)benzenesulfonamide Catalog No. CSN16983

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