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CAS No.: 80-32-0

磺胺氯哒嗪 Catalog No. CSN20802

Synonyms: 磺胺氯哒嗪;Sulfachlorpyridazine

Sulfachloropyridazine is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

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技术信息

生物活性

描述Sulfachloropyridazine (SCP) is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine^[1]. In addition, SCP, SMP (sulfamethoxypyridazine), and sulfadiazine (SDZ) were found to be capable of inhibiting the clinically observed drug-resistant mutants^[2]. SCP may act on three signaling pathways, i.e., Pathway I, II and III, which triggers, maintains and destroys the homeostasis of A. fischeri respectively. In Pathway I, SCP changes the active form of LitR that regulates the expression of lux-related genes, inducing inhibition on bacterial growth while stimulation on luminescence; in Pathway II, SCP facilitates the production of C6HSL signaling molecules, maintaining the homeostasis in LitR and DHPS proteins; whereas in Pathway III, SCP typically combines with DHPS to inhibit the folate metabolism^[3].
参考文献

[1] Dirany A, Sirés I, Oturan N, Ozcan A, Oturan MA. Electrochemical treatment of the antibiotic sulfachloropyridazine: kinetics, reaction pathways, and toxicity evolution. Environ Sci Technol. 2012 Apr 3;46(7):4074-82
[2] Iliades P, Meshnick SR, Macreadie IG. Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs. Antimicrob Agents Chemother. 2005 Feb;49(2):741-8
[3] Sun H, Yao Z, Wang D, Wu X, Lin Z, Liu Y. A deep insight into the toxic mechanism for sulfonamides based on bacterial cell-cell communication. Environ Int. 2019 Aug;129:185-193

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5122 mL
- 17.5610 mL
- 35.1220 mL
- 5 mM
- 0.7024 mL
- 3.5122 mL
- 7.0244 mL
- 10 mM
- 0.3512 mL
- 1.7561 mL
- 3.5122 mL

技术信息

CAS号

80-32-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H9ClN4O2S

运输

蓝冰

分子量

284.72

别名

磺胺氯哒嗪;Sulfachlorpyridazine

溶解度

DMSO	155.0 mg/mL (544.4 mM)
Water	insoluble

动物实验配方

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