|4-正丁基间苯二酚|CsnPharm

CAS No.: 18979-61-8

4-Butylresorcinol/4-丁基间苯二酚 Catalog No. CSN23351

Synonyms: Butylresorcinol;4-Butyl-1,3-benzenediol;4-丁基间苯二酚

4-Butylresorcinol, a phenol derivative, is an inhibit of tyrosinase with IC50 of 11.27 μM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM^[1]. 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. 4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system. 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF (microphthalmia-associated transcription factor) expression^[2].
参考文献

[1] Jiang Y, Du Z, Xue G, Chen Q, Lu Y, Zheng X, Conney AH, Zhang K. Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinase inhibitors. Molecules. 2013 Apr 3;18(4):3948-61
[2] Kim DS, Kim SY, Park SH, Choi YG, Kwon SB, Kim MK, Na JI, Youn SW, Park KC. Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. Biol Pharm Bull. 2005 Dec;28(12):2216-9

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.0161 mL
- 30.0806 mL
- 60.1612 mL
- 5 mM
- 1.2032 mL
- 6.0161 mL
- 12.0322 mL
- 10 mM
- 0.6016 mL
- 3.0081 mL
- 6.0161 mL

技术信息

CAS号

18979-61-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H14O2

运输

蓝冰

分子量

166.22

别名

Butylresorcinol;4-Butyl-1,3-benzenediol;4-丁基间苯二酚

溶解度

DMSO	34.0 mg/mL (204.5 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

4-Butylresorcinol/4-丁基间苯二酚 Catalog No. CSN23351

靶点选择性

请登录您的专属账户

确认信息